Protein Alignment Sur and pgp-11

DIOPT Version :9

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_001364583.1
• Gene: pgp-11 / 183971
• WormBaseID: WBGene00004005
• Length: 1241
• Species: Caenorhabditis elegans
• Alignment Length: 1999
• Identity: 365/1999 - (18%)
• Similarity: 619/1999 - (30%)
• Gaps: 838/1999 - (41%)

  Fly   274 YTEKKKKSNSSPS------LWYCYIKNSWQMFALGGILKLAGDLFALIGPLAIQKIVEYIEQLYA 332
            :.::.|.|:.:||      |...:.|.|..:|.:..:      :.||:|. .||.:|..|
 Worm    14 FGDESKVSDVTPSIRQSLNLMINFAKKSDLIFIITAL------ICALLGG-TIQPVVLLI----- 66

  Fly   333 QASEPPAKSPGNEVANVLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAA 397
                      |..:.::.|:.....|.  ||.         :||..  .|:..|.....|:|:.|
 Worm    67 ----------GGWITDLYLTNGNTAGN--DEF---------LYSVL--TLIYAGLGFGVIILVLA 108

  Fly   398 ITQGALSQASTHILNMTGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKND 462
            :.||...|..|.       ||..|:     ||..|             |.|....:...:|
 Worm   109 LIQGVCIQRGTS-------RILDSI-----RKEFL-------------GAVLRQDANWLDK---- 144

  Fly   463 DSMATPEHVDNPSEPNISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGI 527
                              |..||||..:.|:...|.:         .:..|..:::      .|.
 Worm   145 ------------------HSSGSITCQLNENIEVISD---------GLGNKCCMLV------RGF 176

  Fly   528 SAVIGS-IACIVI----------MTPLQFFIGNAMSKNAEVIAGYTDERLKR--------IHDTL 573
            :....| |||..|          |.|:..|:.:.::|..||    ::|.|..        |.:::
 Worm   177 AMFTSSIIACAFINWQLTFITFTMGPVSAFVLHLLTKVNEV----SNEELMSLSAQSHAIIEESI 237

  Fly   574 VGIKVIKLNAWDEVFLKKIQEARRKELKYLNKDATFWTLMAVLTHIATVLITFVTLGVYVWLHRD 638
            :.::.::........:.|:.:...|..|:.|| :|||.  .....:|..:|.|:| |:.::.
 Worm   238 LNVRTVQSCNGQNFMITKLNQVNEKIKKFYNK-STFWA--GFFDGLALFVIYFIT-GISLFF--- 295

  Fly   639 QEFDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGI--RNM 701
                  ..||:.:..:.:...|.|::..|.|                      ...|.|:  .:|
 Worm   296 ------GCRLYFNQEIGKAGDVILIVNTICV----------------------TGYFLGLLGPHM 332

  Fly   702 ARILSKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDI 766
            :.:...:.:.|.:|:|.|.                   |.||:..|
 Worm   333 SSLQQAATSFLLLYKTIES-------------------APKSEGKE------------------- 359

  Fly   767 SPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKM 831
                    |..|:                  ...||::..|.|.|..        :.||:.:|:
 Worm   360 --------GEIKI------------------SSTRGNIEFRDVRFKY--------FTRDNEVLQ- 389

  Fly   832 PDDIAVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTS---LLSALLMEMP- 892
                      ||                 .:.|..|:...:||.:|.||::   ||:.|.....
 Worm   390 ----------GL-----------------SLQVLPGQTVALVGTSGCGKSTSIGLLTKLYRASEG 427

  Fly   893 --LLAG---NMFWHKTC--TISYVSQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIEL 950
              |:.|   :|...|:.  .|..|.|:|.|.:.||.|||..|.:...:......:.......||.
 Worm   428 EILIDGKNIDMLDAKSLRQQIGIVQQEPKLFDGTIMENIKLGRNVDEETIKTAADIANASSFIEK 492

  Fly   951 MPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQK 1015
            :..|..:.:|..|:.:||||:|||.||||:.:|.:::::|:..::||:. .|||    :.:.|.|
 Worm   493 LENGYETRLGPGGVQLSGGQKQRICIARALVTSPSILLLDEATSALDSH-NEHI----VNKALTK 552

  Fly  1016 SN--RTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNP 1078
            ::  ||.|::..:|..:|..:.:..:..|:.:..|::.::.|:        ..|.|.. ||:...
 Worm   553 ASEGRTTIIIAHRLSSLKSVDRIYVLDQGKTKEIGTHDELILL--------GGIYARL-AKSQEV 608

  Fly  1079 SQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACHADAIDGSGCI---SVANMQSNVVEED 1140
            .|:..:....|..:..:.:.|.|  |::.:            |:.:..|   ...|...:|:.|:
 Worm   609 EQSSKKDWEREELRRAEKMKKKG--RTVEI------------IEPNSTILQEHEHNFVGSVITEN 659

  Fly  1141 DQVSVSYPIGNASCGG----FN-LQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGR 1200
            ::..:|:       .|    || |.:.|.::.....|:  :|..|:.|.           :.:|.
 Worm   660 EEQKISF-------SGISKLFNYLPKHRKTLILIIALL--IPRAIELCS-----------YGIGM 704

  Fly  1201 RGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATS----CSSYAESSVDGGDLATAAPEP 1261
            ..:..|....:...::....|....:::|  ::..:|.||    |
 Worm   705 SFAFKTLQRSKDDYMTWNYITLAQQTLAG--ITFWILHTSLMYLC-------------------- 747

  Fly  1262 RVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRR 1326
               .|.                   |.||.| :||                        |:.|..
 Worm   748 ---GWL-------------------ANEVMN-EVK------------------------QEMLSE 765

  Fly  1327 MSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKE 1391
            :    .||                      |:.:|             ...|..|..||:
 Worm   766 V----LNK----------------------PIPYF-------------DNPETSPSACVS----- 786

  Fly  1392 TTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKI 1456
            ..|:...|||:..|.
 Worm   787 RIISHAHNCYACLDH-------------------------------------------------- 801

  Fly  1457 SDDIYLMYIRAAGLPIITIFFITALIWQCLRVYTDIWLQQWSNVHGRVASKGHVVLHPSEQDHEV 1521
                     ||    |..::||...|:..|..:..:|                          |:
 Worm   802 ---------RA----IRFVWFIAGTIFSLLLAFPFVW--------------------------EL 827

  Fly  1522 TYYFRMYAAISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFS 1586
            .              ::.|..|                 :|.||.  :|||..|      .:|..
 Worm   828 G--------------VLGLGIT-----------------ILLTIF--SLHFVSV------AHRAH 853

  Fly  1587 NDMAVIDKKIAATGQRLLQFTLLCLSAILINVTITPWILVLTLPICGAYYLIQKFYRCSARELQR 1651
            ::.:|:||    :|:              ..|.|...|..:.|.....|:
 Worm   854 SEKSVMDK----SGE--------------FAVEIVEHIRAIKLLAVEGYF--------------- 885

  Fly  1652 IENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAY-ALLNTSHRWLGVSLDYL 1715
             ||                     .|::..:.:||.     .|.|.: :.||     ..::..|:
 Worm   886 -EN---------------------KFSEYLKTSEIY-----ENKIGFVSSLN-----FAITQSYV 918

  Fly  1716 GGC---IVFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAI 1777
            ..|   :.||.|:..           |..                         |.||..|.||.
 Worm   919 FACDMLLFFVGTLLI-----------YHG-------------------------RYSPDKVFLAF 947

  Fly  1778 NYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDV 1842
            |                 ..:|.|..|...:.:
 Worm   948 N-----------------GAQMSAWGVMYFSPW-------------------------------- 963

  Fly  1843 SAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNA 1907
            ..|:.|.|.|             |..:....|:.|
 Worm   964 FPEIVRGSAS-------------ANQIFSFFDKNR------------------------------ 985

  Fly  1908 GNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSV 1972
                                      |..||.:...::..:.:..|.....|:.|.|
 Worm   986 --------------------------TNSTSGLSKPEINGKVEVSDVTFAYPSTPHR-------- 1016

  Fly  1973 PISWPQRGDIHFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTR 2037
                                    ||....:|.||.|..|.:.|.:|.|||::...|........
 Worm  1017 ------------------------NVCEGFSLNIPKGHSIALVGASGCGKSTIISMLERFYSAKA 1057

  Fly  2038 GHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLD---PHGYFQDLQLWNCLELAQLKE 2099
            |.|.:||.||..|..:.||..:|::.|:..|||||||||:.   .....:::|  ...:.|....
 Worm  1058 GRISVDDNDIDGIDVNHLRNNISVVGQEPVLFNATIRENITIGIDEVSVEEVQ--KACKAANAAG 1120

  Fly  2100 FVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADL 2164
            |:.. .|||.||::.:||.:||.|.:|.:.:||||:|....|:||||||.||:.:|..:.||...
 Worm  1121 FIES-FPLGYDTIVGEGGASLSGGQKQRIAIARAIIRKPKILLLDEATSALDTQSEEIVQKALRS 1184

  Fly  2165 AFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEGSVFR 2213
            |..|||.|.:||||:|:...|.:..:.:|.:.|.|...||..::....|
 Worm  1185 ATTGRTSIIVAHRLSTVQHCDTIYYISRGAVAEYGTHAELVAMDSKYAR 1233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
pgp-11	NP_001364583.1	PTZ00265	38..1235	CDD:240339	360/1975 (18%)
		MdlB	46..607	CDD:224055	159/810 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910