Protein Alignment Sur and mrp-3

DIOPT Version :10

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_001359552.1
• Gene: mrp-3 / 181677
• WormBaseID: WBGene00003409
• Length: 1505
• Species: Caenorhabditis elegans
• Alignment Length: 2204
• Identity: 476/2204 - (21%)
• Similarity: 758/2204 - (34%)
• Gaps: 867/2204 - (39%)

  Fly   122 WNALFS------------TLLTLMLMLYHRMVERKKATVFLYASTAVEALT-FALL--SNE---- 167
            |:.|.|            .|...:|.::..:.|.|..|..|:......:.| .|||  :||
 Worm    51 WSTLMSLKWFVASLLIIDRLFVFLLAVWESLFEHKNVTADLFIIPFFHSFTLLALLIATNEVRRA 115

  Fly   168 -------------LFELVRYEDFLELQTC-----LVA-MSAMCMVSLAMLDGLTVYKECYHDDYL 213
                         ||.:....:|.:..|.     ||| :.....|:......|.|.:...|  ::
 Worm   116 GIHSSGPLFCIWMLFAVAAVPEFYQWMTTGSQPELVARIDFFRYVAYLTYFPLVVAEFVLH--FV 178

  Fly   214 DD-------YGKIGYKHSMATFYSKSCFWWLTPLLWLGYKEPLELEDL----------------- 254
            .|       |..:......|.|.|:....|.|.::.|||:..|..:|:
 Worm   179 SDPFPMPRGYQNLKCPEENANFISRQLLLWFTQIISLGYERTLVADDVFEMDSQMDQEYLKARWK 243

  Fly   255 ------------GQMKLEDS---ARS---------HYDHFLYIYTEKKKKSNSSPSLWYCYIKNS 295
                        .|:||:|.   ||:         .::::..:..:.|.:....||:    |...
 Worm   244 TEWLKQTEKAREKQVKLDDKRERARTGSEKAPLLGTFNNYGAVNLDDKDRVIVQPSV----IVTL 304

  Fly   296 WQMF---ALGG-ILKLAGDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVAN-VLLSTSR 355
            ||:.   .||| .:|...||.....|..:..::.:||            :|...:.| :.|:...
 Worm   305 WQIMKWEILGGSFIKFLSDLLQFANPTFLNYLILFIE------------TPNAPLINGIGLAVGL 357

  Fly   356 ILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTHILNMT--GIRI 418
            .|..:...:|                                        .:|:.:.||  |.:|
 Worm   358 FLAGQIKSLF----------------------------------------MNTYFIAMTRVGAKI 382

  Fly   419 KTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISHDI 483
            :|.|...:|.|||||                  |:|:..::                      .:
 Worm   383 QTMLSCAVYEKSLLL------------------SNTARRER----------------------TV 407

  Fly   484 GSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFFIG 548
            |.:.|.::.|..........|...|:.||:|.:.:.||...:|: ||...|..::.:.|:...:.
 Worm   408 GEMVNILSIDVDRFRMITPQIQQYWSSPFQIIICMVLLSQTIGV-AVWAGIVVMISIVPINICVS 471

  Fly   549 NAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELKYLNKDATFWTLM 613
            ....:....:..|.|||::.|::.|.||||:||:||:....:.|:..|.||||.:.:.|...|..
 Worm   472 MITKRWQLRLMKYKDERIRLINEVLNGIKVVKLSAWETAMEETIERVRDKELKMIKQSALLKTFA 536

  Fly   614 AVLTHIATVLITFVTLGVYVWLHRDQEFDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVS 678
            ..|...|.|.:...:..|:|.:  |.:..|..:..|.||:||..|..||::....|...:...||
 Worm   537 DCLNVGAPVFVALSSFTVFVLI--DPKNVLTPNIAFVSLSLFNLLRGPLMMAAELVAQTVQLVVS 599

  Fly   679 TRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQKS 743
            .:|:..||...|:.                                  ||..:..:
 Worm   600 NKRVRTFLCEKEVD----------------------------------TAAIDKEI--------- 621

  Fly   744 QTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERP 808
                                                   |.||..||
 Worm   622 ---------------------------------------RGELYTNT------------------ 629

  Fly   809 VEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVV 873
                                        |.|:.|.|.|.......:..:.   .:....:|..||
 Worm   630 ----------------------------VEIHSGSFAWDSAEARILSDIE---FLAGSKELVTVV 663

  Fly   874 GKNGSGKTSLLSALLMEMPLLAGNMFWHKTC-------TISYVSQQPWLLNDTIRENILFGESFR 931
            |..||||:|||.|.|.||         .|.|       :::|:|||||:||.::::|:|......
 Worm   664 GSVGSGKSSLLLAALGEM---------EKVCGYVGVRGSVAYLSQQPWILNQSLKKNVLMQADLN 719

  Fly   932 PKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVVIMDDPLASL 996
            ...|..|:|:||||.|::.:|.||.:.|||:|||:||||:.|||:|||:|.|.:|..:||||:::
 Worm   720 DVLYKKVIESCALKEDLKQLPDGDDTEIGEKGINLSGGQKARIALARAVYQSKDVYFLDDPLSAV 784

  Fly   997 DNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQPRIT 1061
            |..||:|||.:.|......|:.|.||||.....::|:..:|.:||||::.||:|
 Worm   785 DAHVGKHIFDNVIGPNGMLSHTTRILVTNCTSFLQESGKIIVMKDGRIKHCGTY----------- 838

  Fly  1062 AEWNAIIAMAKAKN-----DN----PSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACH 1117
               |.::...:|:.     ||    ..::.||::.||.                          :
 Worm   839 ---NELLTDVEAREYLQEVDNEYAQAQESSGEESGGEE--------------------------N 874

  Fly  1118 ADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDE 1182
            :|.:.|    |:|:
 Worm   875 SDILPG----SIAS--------------------------------------------------- 884

  Fly  1183 CQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAES 1247
                               |||.:    |||.||.::.....|||
 Worm   885 -------------------GSRMS----RLSRLSKISRKKSKSSI-------------------- 906

  Fly  1248 SVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPL 1312
                                                    :|...||...::|
 Worm   907 ----------------------------------------VEKKKPDALITKE------------ 919

  Fly  1313 DDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQS 1377
                                                                             
 Worm   920 ----------------------------------------------------------------- 919

  Fly  1378 EEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMPL 1442
                                                                             
 Worm   920 ----------------------------------------------------------------- 919

  Fly  1443 ARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFITALIWQ-CLRVYTDIWLQQWSNVHGRVAS 1506
                   |...|:::..:||:|.:|.|:....:.:..|::.. ...:...:||..||:.:..:.
 Worm   920 -------EAAIGRVNPGVYLLYFKAMGIVTYVLPYAIAVVLNVSFALGRSLWLTAWSDANIDIN- 976

  Fly  1507 KGHVVLHPSEQDHEVTYYFRMYAAISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLH 1571
                  ||...  .|.....:||......:|....|.......|..|.:|||..||..:|...|.
 Worm   977 ------HPDTM--SVGARLGVYAGFGITEVIFLFFSLVLLLIGGVAASKNLHKPLLHNVLRNPLS 1033

  Fly  1572 FFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVTITPWILVLTLPICGAYY 1636
            :|.:||:|||:||.:.||.|:|.:::::.:.|:...:..:..:||....||..:.:.:|:...|:
 Worm  1034 YFDITPIGRIINRLAKDMEVVDLRLSSSFRFLVMALINMVQTVLIVSYTTPLFIAIIIPVFIIYF 1098

  Fly  1637 LIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALL 1701
            .:.|:...|.|:||||.:.|.||:.|:.|||:||::|:|||.....|.....:.|..:.......
 Worm  1099 FVLKYSIKSTRQLQRIASLTRSPIFSNFSETLQGISTVRAFQWSDEFVRRNDEHLNTHVKCSYYS 1163

  Fly  1702 NTSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSEL 1766
            ..::|||.:.|:.||..::|.|.:.|:..                                 .|.
 Worm  1164 QMANRWLSIRLELLGNIVIFSAAILAIIG---------------------------------KES 1195

  Fly  1767 RPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADADADVDAD 1831
            ..:..::||:::|:|.:...||..|:.:.::|....|||||..|::
 Worm  1196 GITAGMLGLSVSYSLNITFMLNMFVRQINEVETNVVSVERIDEYSK------------------- 1241

  Fly  1832 LDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHEN 1896
                              ::|:|                    :.|:
 Worm  1242 ------------------TKSEA--------------------EWRL------------------ 1250

  Fly  1897 GAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNE 1961
                            |.|:|
 Worm  1251 ----------------DNNNL-------------------------------------------- 1255

  Fly  1962 PARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLG 2026
                       |.:||..|.::.::.|.||..:...|:..::|.|..||::|:|||||:|||||.
 Worm  1256 -----------PSNWPTGGAVNIEDYSCRYRDELDLVLKQISLNILPGQKVGVCGRTGAGKSSLA 1309

  Fly  2027 LSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNC 2091
            |:||.:::...|:|.||......|...:||.:|:||||:..||..|:|.|:||.|.|.|.|||..
 Worm  1310 LALFRIVEAADGNISIDQTITSHIGLHDLREKLTIIPQENVLFANTLRFNIDPKGQFTDQQLWLA 1374

  Fly  2092 LELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTES 2156
            ||.:.||..|. .||..|::.:.:||.|.|.|.||||||.||:||.|..|||||||:.:|:.|::
 Worm  1375 LENSNLKAHVE-LLPHKLESPVAEGGENFSVGQRQLLCLTRALLRKSKVLVLDEATAGIDNRTDT 1438

  Fly  2157 ALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEGSVFRGL 2215
            .:.......|...|||||||||.||:||||:||:|.|||||||.|.||.:...|.|.||
 Worm  1439 MVQATIREKFADSTIITIAHRLHTIIDYDRIIVMDAGRIVEDGIPGELLKNRNSQFYGL 1497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	ABC_6TM_SUR1_D1_like	301..682	CDD:350035	84/384 (22%)
		TM helix 1	301..324	CDD:350035	7/23 (30%)
		TM helix 2	385..433	CDD:350035	11/49 (22%)
		TM helix 3	480..525	CDD:350035	10/44 (23%)
		TM helix 4	526..575	CDD:350035	11/48 (23%)
		TM helix 5	587..631	CDD:350035	11/43 (26%)
		TM helix 6	648..681	CDD:350035	11/32 (34%)
		ABCC_MRP_domain1	837..1043	CDD:213217	83/212 (39%)
		ABC_6TM_SUR1_D2_like	1475..1811	CDD:350046	85/336 (25%)
		TM helix 1	1475..1496	CDD:350046	3/21 (14%)
		TM helix 2	1520..1568	CDD:350046	13/47 (28%)
		TM helix 3	1575..1620	CDD:350046	14/44 (32%)
		TM helix 4	1621..1670	CDD:350046	18/48 (38%)
		TM helix 5	1682..1727	CDD:350046	10/44 (23%)
		TM helix 6	1777..1810	CDD:350046	11/32 (34%)
		ABCC_MRP_domain2	1980..2201	CDD:213211	107/220 (49%)
mrp-3	NP_001359552.1	MRP_assoc_pro	25..1501	CDD:188098	476/2204 (22%)