DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sur and mrp-3

DIOPT Version :9

Sequence 1:	NP_001334732.1	Gene:	Sur / 34350	FlyBaseID:	FBgn0028675	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	NP_001359552.1	Gene:	mrp-3 / 181677	WormBaseID:	WBGene00003409	Length:	1505	Species:	Caenorhabditis elegans

Alignment Length:	2204	Identity:	476/2204 - (21%)
Similarity:	758/2204 - (34%)	Gaps:	867/2204 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 WNALFS------------TLLTLMLMLYHRMVERKKATVFLYASTAVEALT-FALL--SNE---- 167
            |:.|.|            .|...:|.::..:.|.|..|..|:......:.| .|||  :||
Worm    51 WSTLMSLKWFVASLLIIDRLFVFLLAVWESLFEHKNVTADLFIIPFFHSFTLLALLIATNEVRRA 115

  Fly   168 -------------LFELVRYEDFLELQTC-----LVA-MSAMCMVSLAMLDGLTVYKECYHDDYL 213
                         ||.:....:|.:..|.     ||| :.....|:......|.|.:...|  ::
Worm   116 GIHSSGPLFCIWMLFAVAAVPEFYQWMTTGSQPELVARIDFFRYVAYLTYFPLVVAEFVLH--FV 178

  Fly   214 DD-------YGKIGYKHSMATFYSKSCFWWLTPLLWLGYKEPLELEDL----------------- 254
            .|       |..:......|.|.|:....|.|.::.|||:..|..:|:
Worm   179 SDPFPMPRGYQNLKCPEENANFISRQLLLWFTQIISLGYERTLVADDVFEMDSQMDQEYLKARWK 243

  Fly   255 ------------GQMKLEDS---ARS---------HYDHFLYIYTEKKKKSNSSPSLWYCYIKNS 295
                        .|:||:|.   ||:         .::::..:..:.|.:....||:    |...
Worm   244 TEWLKQTEKAREKQVKLDDKRERARTGSEKAPLLGTFNNYGAVNLDDKDRVIVQPSV----IVTL 304

  Fly   296 WQMF---ALGG-ILKLAGDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVAN-VLLSTSR 355
            ||:.   .||| .:|...||.....|..:..::.:||            :|...:.| :.|:...
Worm   305 WQIMKWEILGGSFIKFLSDLLQFANPTFLNYLILFIE------------TPNAPLINGIGLAVGL 357

  Fly   356 ILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTHILNMT--GIRI 418
            .|..:...:|                                        .:|:.:.||  |.:|
Worm   358 FLAGQIKSLF----------------------------------------MNTYFIAMTRVGAKI 382

  Fly   419 KTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISHDI 483
            :|.|...:|.|||||                  |:|:..::                      .:
Worm   383 QTMLSCAVYEKSLLL------------------SNTARRER----------------------TV 407

  Fly   484 GSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFFIG 548
            |.:.|.::.|..........|...|:.||:|.:.:.||...:|: ||...|..::.:.|:...:.
Worm   408 GEMVNILSIDVDRFRMITPQIQQYWSSPFQIIICMVLLSQTIGV-AVWAGIVVMISIVPINICVS 471

  Fly   549 NAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELKYLNKDATFWTLM 613
            ....:....:..|.|||::.|::.|.||||:||:||:....:.|:..|.||||.:.:.|...|..
Worm   472 MITKRWQLRLMKYKDERIRLINEVLNGIKVVKLSAWETAMEETIERVRDKELKMIKQSALLKTFA 536

  Fly   614 AVLTHIATVLITFVTLGVYVWLHRDQEFDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVS 678
            ..|...|.|.:...:..|:|.:  |.:..|..:..|.||:||..|..||::....|...:...||
Worm   537 DCLNVGAPVFVALSSFTVFVLI--DPKNVLTPNIAFVSLSLFNLLRGPLMMAAELVAQTVQLVVS 599

  Fly   679 TRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQKS 743
            .:|:..||...|:.                                  ||..:..:
Worm   600 NKRVRTFLCEKEVD----------------------------------TAAIDKEI--------- 621

  Fly   744 QTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERP 808
                                                   |.||..||
Worm   622 ---------------------------------------RGELYTNT------------------ 629

  Fly   809 VEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVV 873
                                        |.|:.|.|.|.......:..:.   .:....:|..||
Worm   630 ----------------------------VEIHSGSFAWDSAEARILSDIE---FLAGSKELVTVV 663

  Fly   874 GKNGSGKTSLLSALLMEMPLLAGNMFWHKTC-------TISYVSQQPWLLNDTIRENILFGESFR 931
            |..||||:|||.|.|.||         .|.|       :::|:|||||:||.::::|:|......
Worm   664 GSVGSGKSSLLLAALGEM---------EKVCGYVGVRGSVAYLSQQPWILNQSLKKNVLMQADLN 719

  Fly   932 PKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVVIMDDPLASL 996
            ...|..|:|:||||.|::.:|.||.:.|||:|||:||||:.|||:|||:|.|.:|..:||||:::
Worm   720 DVLYKKVIESCALKEDLKQLPDGDDTEIGEKGINLSGGQKARIALARAVYQSKDVYFLDDPLSAV 784

  Fly   997 DNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQPRIT 1061
            |..||:|||.:.|......|:.|.||||.....::|:..:|.:||||::.||:|
Worm   785 DAHVGKHIFDNVIGPNGMLSHTTRILVTNCTSFLQESGKIIVMKDGRIKHCGTY----------- 838

  Fly  1062 AEWNAIIAMAKAKN-----DN----PSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACH 1117
               |.::...:|:.     ||    ..::.||::.||.                          :
Worm   839 ---NELLTDVEAREYLQEVDNEYAQAQESSGEESGGEE--------------------------N 874

  Fly  1118 ADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDE 1182
            :|.:.|    |:|:
Worm   875 SDILPG----SIAS--------------------------------------------------- 884

  Fly  1183 CQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAES 1247
                               |||.:    |||.||.::.....|||
Worm   885 -------------------GSRMS----RLSRLSKISRKKSKSSI-------------------- 906

  Fly  1248 SVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPL 1312
                                                    :|...||...::|
Worm   907 ----------------------------------------VEKKKPDALITKE------------ 919

  Fly  1313 DDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQS 1377

Worm   920 ----------------------------------------------------------------- 919

  Fly  1378 EEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMPL 1442

Worm   920 ----------------------------------------------------------------- 919

  Fly  1443 ARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFITALIWQ-CLRVYTDIWLQQWSNVHGRVAS 1506
                   |...|:::..:||:|.:|.|:....:.:..|::.. ...:...:||..||:.:..:.
Worm   920 -------EAAIGRVNPGVYLLYFKAMGIVTYVLPYAIAVVLNVSFALGRSLWLTAWSDANIDIN- 976

  Fly  1507 KGHVVLHPSEQDHEVTYYFRMYAAISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLH 1571
                  ||...  .|.....:||......:|....|.......|..|.:|||..||..:|...|.
Worm   977 ------HPDTM--SVGARLGVYAGFGITEVIFLFFSLVLLLIGGVAASKNLHKPLLHNVLRNPLS 1033

  Fly  1572 FFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVTITPWILVLTLPICGAYY 1636
            :|.:||:|||:||.:.||.|:|.:::::.:.|:...:..:..:||....||..:.:.:|:...|:
Worm  1034 YFDITPIGRIINRLAKDMEVVDLRLSSSFRFLVMALINMVQTVLIVSYTTPLFIAIIIPVFIIYF 1098

  Fly  1637 LIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALL 1701
            .:.|:...|.|:||||.:.|.||:.|:.|||:||::|:|||.....|.....:.|..:.......
Worm  1099 FVLKYSIKSTRQLQRIASLTRSPIFSNFSETLQGISTVRAFQWSDEFVRRNDEHLNTHVKCSYYS 1163

  Fly  1702 NTSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSEL 1766
            ..::|||.:.|:.||..::|.|.:.|:..                                 .|.
Worm  1164 QMANRWLSIRLELLGNIVIFSAAILAIIG---------------------------------KES 1195

  Fly  1767 RPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADADADVDAD 1831
            ..:..::||:::|:|.:...||..|:.:.::|....|||||..|::
Worm  1196 GITAGMLGLSVSYSLNITFMLNMFVRQINEVETNVVSVERIDEYSK------------------- 1241

  Fly  1832 LDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHEN 1896
                              ::|:|                    :.|:
Worm  1242 ------------------TKSEA--------------------EWRL------------------ 1250

  Fly  1897 GAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNE 1961
                            |.|:|
Worm  1251 ----------------DNNNL-------------------------------------------- 1255

  Fly  1962 PARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLG 2026
                       |.:||..|.::.::.|.||..:...|:..::|.|..||::|:|||||:|||||.
Worm  1256 -----------PSNWPTGGAVNIEDYSCRYRDELDLVLKQISLNILPGQKVGVCGRTGAGKSSLA 1309

  Fly  2027 LSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNC 2091
            |:||.:::...|:|.||......|...:||.:|:||||:..||..|:|.|:||.|.|.|.|||..
Worm  1310 LALFRIVEAADGNISIDQTITSHIGLHDLREKLTIIPQENVLFANTLRFNIDPKGQFTDQQLWLA 1374

  Fly  2092 LELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTES 2156
            ||.:.||..|. .||..|::.:.:||.|.|.|.||||||.||:||.|..|||||||:.:|:.|::
Worm  1375 LENSNLKAHVE-LLPHKLESPVAEGGENFSVGQRQLLCLTRALLRKSKVLVLDEATAGIDNRTDT 1438

  Fly  2157 ALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEGSVFRGL 2215
            .:.......|...|||||||||.||:||||:||:|.|||||||.|.||.:...|.|.||
Worm  1439 MVQATIREKFADSTIITIAHRLHTIIDYDRIIVMDAGRIVEDGIPGELLKNRNSQFYGL 1497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
mrp-3	NP_001359552.1	MRP_assoc_pro	25..1501	CDD:188098	476/2204 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.110