Protein Alignment Sur and mrp-5

DIOPT Version :10

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_510479.1
• Gene: mrp-5 / 181587
• WormBaseID: WBGene00003411
• Length: 1427
• Species: Caenorhabditis elegans
• Alignment Length: 2057
• Identity: 421/2057 - (20%)
• Similarity: 699/2057 - (33%)
• Gaps: 835/2057 - (40%)

  Fly   213 LDDYGKIGYKHSMATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSARSHYDHFLYIYTEK 277
            :||.|          .:|...:.|:.|.|:...:..|:...:......||...:......::.::
 Worm    70 IDDAG----------LFSFVTYSWVFPYLYQAVRGKLDRNQVWGCSFYDSCGLNMARLEVLWEDE 124

  Fly   278 KKKSNSSPSLW---YCYIKNS-W-----QMFALGGILKLAGDLFALIGPLAIQKIVEYIEQLYAQ 333
            ||.:..||||:   |.:|... |     ..|.|         :|..|||..      :|.:|.|.
 Worm   125 KKANAKSPSLFKVIYRFISTRLWFSCAVFFFCL---------IFGFIGPTC------FIRRLIAF 174

  Fly   334 ASEPPAKSPGNEVANVLLS-----TSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIV 393
            |..|..    :|.:.::.|     .:.|...||..|..        |.:||:
 Worm   175 AENPER----DEQSRIVYSYGIALVAAISVVEFARVLS--------YGATWA------------- 214

  Fly   394 LLAAITQGALSQASTHILNMTGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEK 458
                            :...||||::.::..|:|:..|        :|.|..|:.:|
 Worm   215 ----------------VSYRTGIRVRGAVLALLYKNVL--------NSKDLCGKTES-------- 247

  Fly   459 QKNDDSMATPEHVDNPSEPNISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVI----- 518
                                      .:.|....|.:.:.:         |:.|...|::
 Worm   248 --------------------------DVINIFANDGQRLFD---------AVTFAPLVLVGPLVL 277

  Fly   519 -----YLLYMNLGISAVIGSIACIVIMTPLQFFIGNAM--SKNAEVIAGYTDERLKRIHDTLVGI 576
                 ||| |.:|..:::| |....:...:||.:|.:|  .:|..::.  |::|:..:.:.:..|
 Worm   278 VGGIGYLL-MVIGRWSLLG-ILVFFVFDVIQFGLGKSMVACRNLAIVK--TEKRISMMAEIIKYI 338

  Fly   577 KVIKLNAWDEVFLKKIQEARRKELKYLNKDATFWTLMAV---LTHIATVLITFVTLGVYVWLHRD 638
            :::|:|.|:::|..||.:.|::|...:.|.....:|...   :..:...::|||  ||.:
 Worm   339 RIVKMNGWEQIFSAKIDQFRKEEKVQIRKSGYAQSLAIACGPVVPVVAAILTFV--GVVL----- 396

  Fly   639 QEFDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMAR 703
            ...||.||..||::.::..:...:.:.|.....:..|.|:.||::.:|
 Worm   397 AGNDLLASDAFSAITVYFVMLFGIRMIPYGSRYLAEAVVAMRRIQEYL----------------- 444

  Fly   704 ILSKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISP 768
                   .|:.|                             .|...||:..::.:.:.:.....|
 Worm   445 -------LLEQY-----------------------------APYPVTNAEDVVLDCQGATYTYQP 473

  Fly   769 STVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPD 833
            ...:     ..|.:.:|           |.:....|:|.||        .|.|:  |.|.:|..:
 Worm   474 KAAK-----APVDETKE-----------PTENEVIVVETPV--------FTCSF--DKLSIKRGE 512

  Fly   834 DIAVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNM 898
            .||                                   |:|..|.||:::|.|       ::|:|
 Worm   513 HIA-----------------------------------VIGAVGCGKSAILKA-------ISGHM 535

  Fly   899 FW-------HKTCTISYVSQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDL 956
            |.       .::.|: ||.|:.|:.|.|:::|||||:....:||...:..|.|..|:..:..||.
 Worm   536 FTTDDALSVDRSQTV-YVPQKAWIFNGTVQDNILFGDKMNSERYYKAVNGCQLTEDLTTLSVGDR 599

  Fly   957 SIIGERGINISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFI 1021
            :.:||||..:||||:.|:|:|||::.:.|:.:.||..||||.:|...|.:..|:::|:|  :..:
 Worm   600 TEVGERGATLSGGQKARVALARAVFQTKNLYLFDDIFASLDKKVANKIHEEIIQKLLKK--KALM 662

  Fly  1022 LVTQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKT 1086
            :||..:..:...:.::.::.|.:.|.|:: ||                 ...|||      ..||
 Worm   663 MVTNNMELLHHFDRVLFVEGGNIVADGNH-DI-----------------LYEKND------AYKT 703

  Fly  1087 AGERWKLLKNVSKLGLQRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGN 1151
            .
 Worm   704 F---------------------------------------------------------------- 704

  Fly  1152 ASCGGFNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLS 1216
                                        :|.|:
 Worm   705 ----------------------------VDACE-------------------------------- 709

  Fly  1217 TLTATSESSSISGDVLSRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRN 1281
            |..|||.::|..||                                    .|.|
 Worm   710 TYQATSGATSPCGD------------------------------------GPAQ----------- 727

  Fly  1282 ASSPPAMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATN 1346
                ||                       |||..:            :|.|
 Worm   728 ----PA-----------------------PLDAEI------------LRNS-------------- 739

  Fly  1347 SILSISEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRAN 1411
                 ||:           |..|.:|                             ..||:|...|
 Worm   740 -----SED-----------LKGDADK-----------------------------LISDEEDMGN 759

  Fly  1412 VTSSPADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYIRAA-GLPIITI 1475
            .|                                          |:..||..||.|| |.||.|.
 Worm   760 ST------------------------------------------IAWRIYKQYIHAAGGWPIWTC 782

  Fly  1476 FFITALIWQCLRVYTDIWLQQWSNVHGRVASKGH------------VVLHPSEQDHEVTYYFRMY 1528
            ..|..::.....:::..||.:|       ..|||            :.:..|..|..||.:   |
 Worm   783 LVIGFIVNVVSNIFSTYWLSRW-------LKKGHDETTTITNGTEFLEMKTSLADSPVTGF---Y 837

  Fly  1529 AAISCVCIIMALVSTPAGQYAGC-------NARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFS 1586
            ||:..|.:::..:|   |.:..|       .|...|||::.|.::|....||..||.|||:||||
 Worm   838 AAVYLVALVVLTIS---GLFKACVFVKVSLTAATRLHDRMFQAVIHGATSFFDSTPTGRILNRFS 899

  Fly  1587 NDMAVIDKKIAATGQRLLQFTLLCLSAILINVTITPWILVLTLPICGAYYLIQKFYRCSARELQR 1651
            .||..||.|:..|.:..||..:.||..:::..::.|:.|:..:|:...:.:....:|...|.|:|
 Worm   900 KDMDEIDVKLPFTAEVFLQNMITCLGFLVVITSVFPYFLLFAIPLFVVFVVFVSCFRAGIRNLKR 964

  Fly  1652 IENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWLGVSLDYLG 1716
            .|:.:.||:..|:|.:::|:|||..|.|..||.|:|.|.|:.|:.|..:..::.|||.|.||.|
 Worm   965 SEHISRSPLYDHVSASLEGITTIHTFQQSNRFLEVLKKHLDCNSGAIFMFQSAMRWLAVWLDLL- 1028

  Fly  1717 GCIVFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTL 1781
             .:|..|.|..||.....                         |.||::       .|:||.:.:
 Worm  1029 -VVVMTAIVALLTVMLTG-------------------------TVSPAD-------AGMAIAFAV 1060

  Fly  1782 LVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEV 1846
            .:.....:.|:...::|....||||:::||.
 Worm  1061 QMSGIFQFAVRTQTELEAKMTSVERVSYYAD---------------------------------- 1091

  Fly  1847 DRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVT 1911
                                 ::.|||:...             |||.:
 Worm  1092 ---------------------NIPEDGEWNT-------------RQGLD---------------- 1106

  Fly  1912 GDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISW 1976
                                                                        :..||
 Worm  1107 ------------------------------------------------------------IESSW 1111

  Fly  1977 PQRGDIHFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIY 2041
            |..|.|:|..|:|||.......::::|.:|..|:::||.||||||||||...:|.:...|.|.||
 Worm  1112 PANGQINFSEVNLRYRKSHPLALNDITFEIKGGEKVGIIGRTGSGKSSLANLIFRLYPVTNGTIY 1176

  Fly  2042 IDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLP 2106
            ||.|||:.:...:||..:|.|.||..||:.|:|.||||...:.|..:|..||...||..|.. |.
 Worm  1177 IDGVDIRTVGLVKLRRGISAIAQDPSLFSGTVRFNLDPSLEYSDSMIWEALEKCHLKTLVQS-LD 1240

  Fly  2107 LGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTI 2171
            ..|:..:..||.|.|.|.|||.|||||:|..|..::|||||:.:|:.|:..:.:.....|...|:
 Worm  1241 KKLEADVSHGGNNFSVGERQLFCLARALLMKSRIVILDEATASVDAGTDKLIQEVIKTVFADATV 1305

  Fly  2172 ITIAHRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEGSVFR 2213
            |.|||||..:.:.||::.|..|:::....|:|:.:.:.||::
 Worm  1306 IIIAHRLDNVRNMDRIMHLKNGKLINFTTPQEMFKDDWSVYK 1347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	ABC_6TM_SUR1_D1_like	301..682	CDD:350035	75/400 (19%)
		TM helix 1	301..324	CDD:350035	5/22 (23%)
		TM helix 2	385..433	CDD:350035	7/47 (15%)
		TM helix 3	480..525	CDD:350035	9/54 (17%)
		TM helix 4	526..575	CDD:350035	10/50 (20%)
		TM helix 5	587..631	CDD:350035	10/46 (22%)
		TM helix 6	648..681	CDD:350035	5/32 (16%)
		ABCC_MRP_domain1	837..1043	CDD:213217	56/212 (26%)
		ABC_6TM_SUR1_D2_like	1475..1811	CDD:350046	95/354 (27%)
		TM helix 1	1475..1496	CDD:350046	3/20 (15%)
		TM helix 2	1520..1568	CDD:350046	14/54 (26%)
		TM helix 3	1575..1620	CDD:350046	19/44 (43%)
		TM helix 4	1621..1670	CDD:350046	12/48 (25%)
		TM helix 5	1682..1727	CDD:350046	18/44 (41%)
		TM helix 6	1777..1810	CDD:350046	7/32 (22%)
		ABCC_MRP_domain2	1980..2201	CDD:213211	89/220 (40%)
mrp-5	NP_510479.1	MRP_assoc_pro	90..1340	CDD:188098	412/2018 (20%)