Protein Alignment Sur and pgp-8

DIOPT Version :9

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_509811.2
• Gene: pgp-8 / 181277
• WormBaseID: WBGene00004002
• Length: 1243
• Species: Caenorhabditis elegans
• Alignment Length: 1868
• Identity: 330/1868 - (17%)
• Similarity: 590/1868 - (31%)
• Gaps: 814/1868 - (43%)

  Fly   475 SEPNISHDIGSIT----------NHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISA 529
            ::|.:|:..|.::          |:.:.|..::.:.:.:.|....     .|||:
 Worm    53 TQPFMSYTFGEVSQAFVRITAAVNNASLDPSDLEKAYEMFHADMN-----NVVIH---------- 102

  Fly   530 VIGSIACIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNA--WDEVF---- 588
             .|.:.|..:      |.|.......:.|...|..||:  |..:  ::::|.:|  :|.:.
 Worm   103 -FGLVGCAFM------FFGFIQFSLFKYIGDNTTYRLR--HKFI--LRLLKKDAKYFDTISTGYL 156

  Fly   589 -------LKKIQEARRKELKYLNKDATFWTLMAVLTHIATVLITFVTLGVYVWLHRDQEFDLNAS 646
                   |::.:||..:::.::   ..|.|..|:.|.:|  ..|..||..|..:.   .|.:..|
 Worm   157 STVLNDNLERFREAFNEKIAFI---ICFSTDFAIGTALA--FYTSWTLASYGSVF---AFGIVIS 213

  Fly   647 RLFSSLAL------------------FQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQK 693
            .|.:|.::                  ||.|        .:...:|:....|:.||::  |:|: |
 Worm   214 GLLNSTSMMKSNEKQSMHYSNAGAIAFQAL--------CSFKTVISLNGQTQELEKY--SAEL-K 267

  Fly   694 QFEGIRNMARILSKSDASLDMYETQEKS------------NMTMRTAQ----------AENRLNE 736
            :.|...:.......:...|..:.....:            |.||.|..          :...|.|
 Worm   268 EGEKFGSRRAFFLATSRGLSHFFCNALNGTILYVGADLIYNKTMNTVAIVTLFHYMLFSAFSLGE 332

  Fly   737 KRL-------AQKSQTP--ELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPY 792
            ..|       |..|.||  ::.|:...:::|.:::.:..|..|:|.:
 Worm   333 AFLHISYLLNAINSATPIFDVLTSDDDMIENNQDNEQTDSNKTIQGM------------------ 379

  Fly   793 VAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMPVVQL 857
                                                        :|.|:..|.:..:..:.:::
 Worm   380 --------------------------------------------LSFNNVKFAYPSRPDVDILR- 399

  Fly   858 HVPGII--VPKGKLTIVVGKNGSGKTSLLSALL-----MEMPLLAGNMFWHK------TCTISYV 909
               ||.  |.:|:...:||.:||||::::..||     ....:..|:...|.      ...|..|
 Worm   400 ---GISFDVKQGECIALVGASGSGKSTIVQLLLHFYNIQSGTIKIGDSHLHDINLKQLRNAIGVV 461

  Fly   910 SQQPWLLNDTIRENILFG----------ESFR-PKRYDFVLEACALKPDIELMPRGDLSIIGERG 963
            ||:|.|.|.||.|||.||          |:.| ...||||   |.:|..::       :|:||||
 Worm   462 SQEPVLFNTTIEENIRFGNPNATSSEIYEALRKANAYDFV---CNIKDGLK-------TIVGERG 516

  Fly   964 INISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLH 1028
            ..:||||:|||||||.:..:..::::|:..::||: ..|...|..:::  ....||.|::..:|.
 Worm   517 AQLSGGQKQRIAIARVLVKNPAILLLDEATSALDS-ASERAVQLALKK--ASEGRTTIIIAHRLS 578

  Fly  1029 RIKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKL 1093
            .|:..:.::.:.:|::...||:.::
 Worm   579 TIRHCDKIMVMSNGKIAEVGSHEEL---------------------------------------- 603

  Fly  1094 LKNVSKLGLQRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFN 1158
                          ::||.         :.|..:......|..||||
 Worm   604 --------------ISMDR---------EYSNLVRAQFFDSQSVEED------------------ 627

  Fly  1159 LQRKRSSIYGSRHLMYDVPLPIDECQG-DDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATS 1222
                   |.|               || ::||.:
 Worm   628 -------ING---------------QGAEEVIQK------------------------------- 639

  Fly  1223 ESSSISGDVLSRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPA 1287
                                                                         :||
 Worm   640 -------------------------------------------------------------TPP- 642

  Fly  1288 MEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSIS 1352
                             |.:...||::.:
 Worm   643 -----------------NLNDGEPLEELL------------------------------------ 654

  Fly  1353 EESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPA 1417
                                                 |||          :||.|:::|:.
 Worm   655 -------------------------------------KET----------SSDIEIKSNIW---- 668

  Fly  1418 DQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFITALI 1482
                        ||..|...::..|:...|.:.              |:....||     ::.:|
 Worm   669 ------------EVLRECRPDAFLLSMAVIGSA--------------IQGCNFPI-----LSQII 702

  Fly  1483 WQCLRVYTDIWLQQWSNVHG-RVASKGHV---------VLHPSEQDHEVTYY--FRMYAAISCVC 1535
            .|..:.|.         :.| .:.:.||.         |:.|      :|.|  |..:..:|
 Worm   703 VQTYKAYA---------MDGENILTYGHFWAAMFLVLGVIRP------ITLYCQFFFFGKVS--- 749

  Fly  1536 IIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFF---QVTPLGRIVNRF----SNDMAVID 1593
               ..:||            .|..|..|.:|.....|:   :.:|. |:|||.    ||..|.:|
 Worm   750 ---EKLST------------RLRIKSFQHLLSLPCAFYDDPKHSPT-RLVNRLNTDPSNIKAAVD 798

  Fly  1594 KKIAATGQRLLQFTLLCLSAILINVTITPWILVLTLPICGAYY---LIQKFYRCSARE-LQRIEN 1654
            .::.:....::.|:|..|.|...:..:|..: ||..|:  .||   |.:|....|.:| ....||
 Worm   799 ARLGSLLMSMVSFSLAILIACYYSWKLTLQV-VLFFPV--LYYAKFLYKKTTTISIKEDSVAFEN 860

  Fly  1655 ATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHR----WLGVSLDYL 1715
            :....:     |.:..:.|::|.|.:.|...::.:.|       |:|.||:.    .:|::..:.
 Worm   861 SNKIAI-----EVLDNMKTVKALNMEARVINLVMEYL-------AVLKTSYPRRSVVMGLANGFS 913

  Fly  1716 GGCIVFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYT 1780
            .||...|..::                         ..|.||.:.:  .|:.|....:.|
 Worm   914 AGCSQIVYAIS-------------------------FKFGTYLILQ--KEVIPMDMYLSL----- 946

  Fly  1781 LLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAE 1845
                |.|::...:......|.....:..|.|
 Worm   947 ----ITLSYTSNMAGSAISYMPDFRKAIHSA---------------------------------- 973

  Fly  1846 VDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNV 1910
                                                                             
 Worm   974 ----------------------------------------------------------------- 973

  Fly  1911 TGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPIS 1975
               |...|....|||                   :|...|...:.:.
 Worm   974 ---GLIFNLFTYPAT-------------------MPFNSDTGSRSIT------------------ 998

  Fly  1976 WPQRGDIHFDNVSLRYEGQKQ-NVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVL-QTTRG 2038
               :|:::.:||...|..:.. .|:.::.||:.||:.:.|.|.:|||||:: :||..:. :..:|
 Worm   999 ---KGEVNGENVKFHYHQRPDYTVLDSVNLKVEAGKTLAIVGPSGSGKSTI-ISLLEMFYRADQG 1059

  Fly  2039 HIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDL---QLWNCLELAQLKEF 2100
            .|.||:.:::.|..|.||:.|.::.|...|||.:||:|: .:|..:::   ::.|.|::|....|
 Worm  1060 FIKIDNDNVENINLDHLRSNLGLVSQGPVLFNCSIRDNI-LYGLTRNISQTEIENALQIANAFNF 1123

  Fly  2101 VNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLA 2165
            | ..||.||||::.|.|..||.|.:|.:.:.|||||....|:||||||.||:.:|..:..|.|.|
 Worm  1124 V-FQLPQGLDTIVGDRGAQLSGGQKQRIAITRAILRNPKLLLLDEATSALDTESEKIVQNALDTA 1187

  Fly  2166 FRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEGSVFR 2213
            ....:.|.:||||:||::.|.:.||..|::||.|...:|..::|..:|
 Worm  1188 SERLSTIVVAHRLSTIINADSIAVLRNGKVVEQGTHNQLLAVKGDYWR 1235

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
pgp-8	NP_509811.2	PTZ00265	29..1241	CDD:240339	330/1868 (18%)
		ABC_membrane	44..326	CDD:294371	53/317 (17%)
		ABC_MTABC3_MDL1_MDL2	382..617	CDD:213216	70/314 (22%)
		ABC_membrane	685..953	CDD:279056	70/371 (19%)
		ABC_MTABC3_MDL1_MDL2	1005..1240	CDD:213216	86/234 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000