Protein Alignment Sur and pgp-10

DIOPT Version :9

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_509205.2
• Gene: pgp-10 / 180981
• WormBaseID: WBGene00004004
• Length: 1382
• Species: Caenorhabditis elegans
• Alignment Length: 1929
• Identity: 380/1929 - (19%)
• Similarity: 663/1929 - (34%)
• Gaps: 714/1929 - (37%)

  Fly   434 NADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATP-----EHVDNPSEPNISHDIGSITNHM--T 491
            |.:...:.::..|..:.......|.:|:..||..|     .::|:......::|: ::.:.:  :
 Worm     6 NKNESTNKTNEIGNAEKKEEAETEDKKSLKSMIYPIEPSTLYIDDLKNSKKAYDV-TMDDPLDKS 69

  Fly   492 EDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFFI-GNAMS--- 552
            .|::..:.||  ..|.....|..::.:.|:.|.| .||::.|     .:.|..:.| ||.:|
 Worm    70 SDSKPKLGFF--EPYKRLYAFADSIDMQLMAMGL-FSALLQS-----ALPPFVWLIMGNFVSISI 126

  Fly   553 ---------KNAEVIAGY-TDERLKRIHD------TLVGIKV-------IKLNAWDEVFLKKIQE 594
                     ||  :.:.| .|::.  .|.      :::|:.:       .:..||:   :..|::
 Worm   127 LREEGKLGLKN--LTSDYPIDDQF--AHSATPAFISMLGLSIAMFIAAFCQRIAWE---ISSIRQ 184

  Fly   595 ARRKELKYLNK----DATFWTLMAVLTHIATVL-----------------ITF------VTLGVY 632
            ..|.:..|:.|    |.: |.......|:|.:|                 :.|      |.:||.
 Worm   185 VFRIKKAYIRKLLLMDIS-WLESRQSGHVAAMLQESADSIYNGISDHLPMVVFILSYLLVNIGVC 248

  Fly   633 VWLHRDQEFDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEG 697
            :::..|             :.||..|.:||||    :..|:.::.....:|   :.:::|.:...
 Worm   249 LYIQWD-------------VTLFMCLAIPLLI----ISRILYSKWFANTME---EETKLQNKITN 293

  Fly   698 IRN-----MARILSKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQK----SQTPELATN-- 751
            :.|     :..::|       ....::|.|...:.:...::|.|:||...    |.|..|.|.
 Worm   294 LVNETFNCITTVIS-------FAAQKQKINKFEKLSAEHSKLTEERLRSSVVFDSLTQILLTELI 351

  Fly   752 STPLLQNAEESAEDISPSTVQELGHNKL----------------------VQQRRELLRNTPYVA 794
            .|..|........|.||..:..|..|.|                      .::..|:|...|.:.
 Worm   352 FTGALCYGIWRVADNSPGRLCALAINMLYMCVTSISIGFHMNGATRAKDNAKEICEVLNEQPKIE 416

  Fly   795 IRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMPVVQLHV 859
            :....:..::...|    |.|.:    :||.|  :|.....|:...|..|::..:.:..|::
 Worm   417 VELASIDNNIDYVP----VTRCK----YRRQS--MKFMGKGALHFRDIHFSYPSRKETEVLR--- 468

  Fly   860 PGII--VPKGKLTIVVGKNGSGKTSLLSALLMEM--P-----LLAGNMFWHKT-C------TISY 908
             ||.  |..|:...:||.:|||| |.|:|||:..  |     ||.|...  || |      ..|.
 Worm   469 -GISFKVEAGEKIAIVGSSGSGK-STLTALLLRFYDPTKGAILLDGENI--KTMCPDDLRGQCSL 529

  Fly   909 VSQQPWLLNDTIRENILFG--ESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQR 971
            |||:|.|.:.||.:||.:|  ::.:.:..|...:..|.| .|..:|.|..:.:||||..:||||:
 Worm   530 VSQEPVLFDGTISDNIRYGRLDATQQEINDAARKVGAWK-FINSLPDGMQTRVGERGHQLSGGQK 593

  Fly   972 QRIAIARAIYSSANVVIMDDPLASLDN----EVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKE 1032
            ||:|||||:.....|:|.|:..::|||    ||...|       .|.....|.|.:..:|..||.
 Worm   594 QRVAIARAVIRKPIVLIFDEATSALDNIHEEEVNAAI-------DLASEGLTTITIAHRLSTIKN 651

  Fly  1033 AEYLIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNV 1097
            ::.:|.:.:|::...|.                                |.|..|
 Worm   652 SDRIIVLHEGKIVEEGV--------------------------------PDELIA---------- 674

  Fly  1098 SKLGLQRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRK 1162
                         |||
 Worm   675 -------------DAN------------------------------------------------- 677

  Fly  1163 RSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSI 1227
                 |..|.||                                 :..||..|:
 Worm   678 -----GIFHKMY---------------------------------NDQRLDQLT----------- 693

  Fly  1228 SGDVLSRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPA----M 1288
                                                         ..||.|.:..:.||:    |
 Worm   694 ---------------------------------------------QQHQQLHQQQAKPPSLQQQM 713

  Fly  1289 EVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISE 1353
            ..:.|.....::.||:                   ..|.|:..:.|       |..:.|:.|:.:
 Worm   714 SFSPPPNMDPDQQRRA-------------------WARSSLGGNKK-------LGKSYSVNSMEK 752

  Fly  1354 E--SPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSP 1416
            |  ..||:          ..|...:.:.|..|..::|.|:.|.:..|      |.:|....|:..
 Worm   753 EKLKLPVM----------SKKKSERLDYKYSKVHSMDVKQHTDSMHD------DDDLPGKETNFT 801

  Fly  1417 ADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFITAL 1481
                      ||.::. .|.|..:||...||.|             ..:||       :|::  |
 Worm   802 ----------VLKDLI-YSYRTGLPLLAGAIPT-------------TIVRA-------VFYL--L 833

  Fly  1482 IWQCLRVYTDIWLQQWSNVHGRVASKGHVVLHPSEQDHEVTYYFRMYAAISCVCIIMALVSTPAG 1546
            |  |.                :|||...:.:.|   |.|......:.|||....||:..:....|
 Worm   834 I--CF----------------QVASVLEISIAP---DEERALQIFIVAAIYTALIIVKTIFEALG 877

  Fly  1547 Q-------YAGCNARRNLHDKLLQTILHKTLHFF---QVTPLGRIVNRFSNDMAVIDKKIAATGQ 1601
            :       :..|...||   ::.:.:|.....:|   :.:| ||:|::..|:.:.:::.:.....
 Worm   878 RIFIALYGHGFCKFMRN---EMFRKVLRHGAAYFDEERNSP-GRLVHKVINESSTLNEIMEQKLD 938

  Fly  1602 RLLQ------FTLLCLSAILINVTITPWILVLTLPICG----AYYLIQ--KFYRCSARELQRIEN 1654
            .|:.      |:::|  |:.||     |.:.|   :|.    ||::|:  :....:.|:.|.::.
 Worm   939 MLIPGVVCSLFSIVC--ALWIN-----WKMAL---LCSFQFPAYFVIRILQIREGTKRQRQMVDE 993

  Fly  1655 ATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCI 1719
            ...:..::  |..:..::||:|:|.|:.|..:....|:.                     :..|:
 Worm   994 EKKAANLA--SVVLANMSTIKAYNLQSHFYNVFCDALKP---------------------VSQCM 1035

  Fly  1720 VFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVP 1784
            ...:.::||..|   |:..:                ||                       :|:.
 Worm  1036 QKQSLISALVFA---CQYSF----------------TY-----------------------ILIA 1058

  Fly  1785 IYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRS 1849
            |.|::            |.|..:|:                               ::|.
 Worm  1059 ITLHF------------GKVMMLAN-------------------------------EISV----- 1075

  Fly  1850 SQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDG 1914
                                                                .|.:....:|..|
 Worm  1076 ----------------------------------------------------FDYMRVVLLTQFG 1088

  Fly  1915 NHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPAR-KLERYQSVPISWPQ 1978
            .:. |....|:..|..:......:|::..:.||...|.     |..|..| |||
 Worm  1089 ANF-FSQLIASVSDFTKAQIAAENVMRVIREPPVDMDN-----LSEEGLRPKLE----------- 1136

  Fly  1979 RGDIHFDNVSLRYEGQK-QNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLF-GVLQTTRGHIY 2041
             |::...:||.||..:. ..|::||.||:..|:.|.:.|.:||||||: :||| .:...|.|.:.
 Worm  1137 -GNLCLKDVSFRYPSRPIVPVLTNLNLKVRGGESIALVGPSGSGKSSV-ISLFQRMYNATDGVVI 1199

  Fly  2042 IDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVN--GH 2104
            ||..:|:.|.|..||..:..:.|:..||:.||:||:.......:..:...:|.|::.:..|  ..
 Worm  1200 IDKYNIKSINPAYLRRCIVQVGQEPDLFSFTIKENIAFGMMESEATIDKVIEAAKIADIHNFITS 1264

  Fly  2105 LPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGR 2169
            ||.|.||.:.:.|..||.|.:|.:.:||||:|....|:||||||.|||::|..:..|.:...|..
 Worm  1265 LPQGYDTEVGEFGAQLSGGQKQRIAIARAIIRKPTVLLLDEATSALDSASEREVQNAFERVKRST 1329

  Fly  2170 ----TIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEG 2209
                |.|.|||||:||.:.|::.|:..|.|.|:|:..:|..|:|
 Worm  1330 KTQCTCIQIAHRLSTIRNVDKIYVIVHGEIAEEGSHEQLINLKG 1373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
pgp-10	NP_509205.2	MdlB	73..687	CDD:224055	163/823 (20%)
		ABC_membrane	156..381	CDD:294371	47/255 (18%)
		ABC_MTABC3_MDL1_MDL2	450..687	CDD:213216	85/393 (22%)
		ABC_membrane	823..1099	CDD:294371	70/498 (14%)
		MdlB	825..1382	CDD:224055	167/777 (21%)
		P-loop_NTPase	1141..1381	CDD:304359	86/234 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000