Protein Alignment Sur and mrp-7

DIOPT Version :10

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_507812.3
• Gene: mrp-7 / 180289
• WormBaseID: WBGene00003413
• Length: 1525
• Species: Caenorhabditis elegans
• Alignment Length: 2255
• Identity: 506/2255 - (22%)
• Similarity: 799/2255 - (35%)
• Gaps: 808/2255 - (35%)

  Fly    25 NTDICGIDRVRRVFTFFSIFLLLFGLMFVCSRYKKCHKTLLTF----HNGRAAISLLLLALNSFD 85
            |..||....| .|:...:.|||.  |.|:.:   :||.|...|    .:....|.|||:|
 Worm    18 NVSICAQHTV-LVWVPAAFFLLT--LPFLSA---QCHLTAQRFARLPFSAHFIIKLLLVA----- 71

  Fly    86 LARIFLPHQNVRN-LNRLFQSSPRDLNYLVVIGSGEL-WNALFST-LLTLMLMLYHRMVERKKAT 147
                ||...::.. ...||..:.....|.|..|...| |...|.. |:.|...|....::...:.
 Worm    72 ----FLAANSLATWCYVLFSKNSYAAAYYVYPGLWVLVWTGTFLVHLIRLRCGLVSSGIQHVTSL 132

  Fly   148 VFLYASTAVEALTFALLSNELFELVRYEDFLELQTCLVAMSAMCMVSLAMLDG-----LTVYKEC 207
            :||...           :.|.::.:|.|:.......|....:...:|:|.|..     |..:..|
 Worm   133 IFLLCG-----------APEFYQWIRMENSNSFPNDLTTTDSAQFLSIAYLSWYSALILYTFSLC 186

  Fly   208 YHDD---YLDDYGKIGYKHS-----MATFYSKSCFWWLTPLLWLGYKEPLELEDLGQM------- 257
            :.|.   ..|| .|...|.:     .::|.::...||...:.|.|.:..||::|:.::
 Worm   187 FADPRGAKTDD-EKASSKSAASPELQSSFLNRLTLWWFNSIPWTGARRDLEIDDIFELNERSGTE 250

  Fly   258 ---KLEDS----ARSHYDHFLYIYTEK-KKKSNSSPSLWYCYIKNSWQM----FALGGILKLAGD 310
               :|.:|    .|..|.|...|:.:| ..:....|.:....:.:.:.|    |.|...||...|
 Worm   251 FLSELWESFWEPKRLKYIHDTSIWAKKDPSEQEKDPVVIPSVVSSLFMMFRWEFLLASTLKFVSD 315

  Fly   311 LFALIGPLAIQKIVEYIEQLYAQASEPPAKS----PGNEVANVLLSTSRILGTEFDEVFGTNIDK 371
            ......|..:.:::.:|.          ||:    .|..::.::.|.|.:
 Worm   316 TMQFASPFLLHELLNFIS----------AKNAPFWKGMALSILMFSVSEL--------------- 355

  Fly   372 VRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTHILNMTGIRIKTSLQGLIYRKSLLLNAD 436
                    ..|:.||:                    .:|:...|.:|:|||...:|:|:||:
 Worm   356 --------RSLILNGY--------------------FYIMFRMGTKIQTSLTAAVYKKTLLI--- 389

  Fly   437 GGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISHDIGSITNHMTEDTRNIMEFF 501
                         |.|:..|                        ..:|.|.|.|..|........
 Worm   390 -------------SNSARRD------------------------RTVGEIVNLMAIDVERFQMIT 417

  Fly   502 LIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFFIGNAMSKNAEVIAGYTDERL 566
            ..|...|:.|::|...:..|::.||.||:.| :..:||..|:.......:.|.........|||.
 Worm   418 PQIQQFWSCPYQITFALVYLFITLGYSALPG-VVIMVIFVPMNIISSMIVRKWQIEQMKLKDERT 481

  Fly   567 KRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELKYLNKDATFWTLMAVLTHIATVLITFVTLGV 631
            |.:::.|.||||:||.||:......|.|.|.|||..:.|.|....::......:..|:...:.|.
 Worm   482 KMVNEVLNGIKVVKLYAWEVPMEAYIDEIRTKELALIKKSAMVRNILDSFNTASPFLVALFSFGT 546

  Fly   632 YVWLHRDQEFDLNASRL------FSSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSE 690
            :|.        .|.|.|      |.|||||.||..|:.:..:.:...:.|.||.:||:.||.:.|
 Worm   547 FVL--------SNPSHLLTPQIAFVSLALFNQLRSPMTMIALLINQAVQAVVSNKRLKEFLVAEE 603

  Fly   691 IQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPL 755
            :
 Worm   604 L---------------------------------------------------------------- 604

  Fly   756 LQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTD 820
                :|...|.|.:.  |..||
 Worm   605 ----DEKCVDRSVNI--ERSHN------------------------------------------- 620

  Fly   821 SWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLS 885
                           ||.:.:...:|.|:.......|....:..|:..|..||||.||||:|||.
 Worm   621 ---------------AVRVENLTASWDPEEAAGEKTLQDVDLTAPRNSLIAVVGKVGSGKSSLLQ 670

  Fly   886 ALLMEMPLLAGNMFWHKTCTISYVSQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIEL 950
            |||.||..|.|.:  .....::||.||||:.|.|:|:||.||..|..||||.||.|||||.||::
 Worm   671 ALLGEMGKLRGRI--GVNGRVAYVPQQPWIQNMTLRDNITFGRPFDRKRYDQVLYACALKADIKI 733

  Fly   951 MPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQK 1015
            :|.||.:.|||:|||:||||:.|:::|||:|.:.:|.::||||:::|..||.|||:..|......
 Worm   734 LPAGDQTEIGEKGINLSGGQKARVSLARAVYQNLDVYLLDDPLSAVDAHVGRHIFEKVIGPNGLL 798

  Fly  1016 SNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQ 1080
            ..:|.||||..|...|.|:.::.:.:|::|..|::
 Worm   799 REKTRILVTHGLTYTKMADEILVMLEGKIEESGTF------------------------------ 833

  Fly  1081 NPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSV 1145
                                                                             
 Worm   834 ----------------------------------------------------------------- 833

  Fly  1146 SYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSH 1210
                                                             .|.:.|||........
 Worm   834 -------------------------------------------------EHLIKRRGLFFDFMEE 849

  Fly  1211 RLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHH 1275
            ..||       |::||.:|.           |...:....||:         :|.:..|:.|
 Worm   850 YKSG-------SDNSSEAGG-----------SQDDDFEAIGGE---------IQDYMNPEDV--- 884

  Fly  1276 QPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHH 1340
                       .:.|.|                  .||:.:|                .|:
 Worm   885 -----------VLTVTN------------------DLDETIR----------------TPE---- 900

  Fly  1341 PLSATNSILSISEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASD 1405
             |:...|.:| |.|.||....||:         .|:|:.|..|
 Worm   901 -LTTQISTMS-SPEKPPTGTSPAA---------ATESQNKLIK---------------------- 932

  Fly  1406 KELRANVTSSPADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAGL 1470
                               :..:|:                       ||:....|.:|::|||.
 Worm   933 -------------------KEGIAQ-----------------------GKVEIATYQLYVKAAGY 955

  Fly  1471 PIITIFFITALIWQCLRVYTDIWLQQWSNVHGRVASKGHVVLHPSEQDHEVTYYFRM-YAAISCV 1534
            .:...|....:::..|::....||..||:.:...:...    ||..:...:..|..: ::..:|.
 Worm   956 LLSIAFIGFFIVYMTLQILRSFWLSAWSDEYDPDSPSA----HPMAKGWRLGVYGALGFSETACF 1016

  Fly  1535 CI-IMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAA 1598
            .: ::|||      :.|..|.:|||..|:..::...:.|:..||||||:||.:.|:..||..:..
 Worm  1017 FVALLALV------FVGQRASKNLHGPLIHNLMRSPMSFYDTTPLGRILNRCAKDIETIDMMLPM 1075

  Fly  1599 TGQRLLQFTLLCLSAILINVTITPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISH 1663
            ..:.|:...|.....:::.:..||...|:.||:...|.:..::|..::|:|:|:|:...||:.||
 Worm  1076 NFRYLVMCVLQVAFTLIVIIISTPLFAVVILPLALIYLIFLRYYVPTSRQLKRLESVHRSPIYSH 1140

  Fly  1664 LSETIQGVTTIRAFNQQTRFTE----IL--FKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFV 1722
            ..|||||..:||||.:...|.:    ||  |.|...:::      .|:|||.|.|:::|.||:|.
 Worm  1141 FGETIQGAASIRAFGKVDEFRQDSGRILDTFIRCRYSSL------VSNRWLAVRLEFVGNCIIFF 1199

  Fly  1723 ATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYL 1787
            |.:                               :||.........||.::|::::|.|.:...|
 Worm  1200 AAL-------------------------------FAVLSKEFGWITSPGVIGVSVSYALNITEVL 1233

  Fly  1788 NWVVKLLADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQS 1852
            |:.|:.::::|....||||:..|
 Worm  1234 NFAVRQVSEIEANIVSVERVNEY------------------------------------------ 1256

  Fly  1853 DAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHL 1917
                                                                             
 Worm  1257 ----------------------------------------------------------------- 1256

  Fly  1918 NFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDI 1982
                             |.|                     |||...::|..:..| .||.||.:
 Worm  1257 -----------------TNT---------------------PNEAPWRIEGREPAP-GWPSRGVV 1282

  Fly  1983 HFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDI 2047
            .||..|.||......|:.:::..:.||::|||.||||:||||..|:||.:::...|.|.||||::
 Worm  1283 KFDGYSTRYREGLDLVLHDISADVAAGEKIGIVGRTGAGKSSFALALFRMIEAAGGRIVIDDVEV 1347

  Fly  2048 QRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTV 2112
            .:|...:||:.::|||||..||:.|:|.||||...:.|.|:|..||||.||.|..| ||.||...
 Worm  1348 SQIGLHDLRSNITIIPQDPVLFSGTLRFNLDPFFTYSDDQIWRALELAHLKHFAAG-LPDGLLYK 1411

  Fly  2113 ICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHR 2177
            |.:.|.|||.|.|||:.||||:||.:..|||||||:.:|.:|::.:.:.....|:..|:.|||||
 Worm  1412 ISEAGENLSVGQRQLVALARALLRHTRVLVLDEATAAVDVATDALIQETIREEFKECTVFTIAHR 1476

  Fly  2178 LTTILDYDRLIVLDQGRIVEDGNPRELQQLEGSVFRGLLEKGASK 2222
            |.||:||||::|||:|.|:|...|..|...:.|.|..::...|.:
 Worm  1477 LNTIMDYDRIMVLDKGSILEFDTPDALMADKNSAFAKMVADAAEQ 1521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	ABC_6TM_SUR1_D1_like	301..682	CDD:350035	85/390 (22%)
		TM helix 1	301..324	CDD:350035	5/22 (23%)
		TM helix 2	385..433	CDD:350035	11/47 (23%)
		TM helix 3	480..525	CDD:350035	10/44 (23%)
		TM helix 4	526..575	CDD:350035	13/48 (27%)
		TM helix 5	587..631	CDD:350035	9/43 (21%)
		TM helix 6	648..681	CDD:350035	13/38 (34%)
		ABCC_MRP_domain1	837..1043	CDD:213217	89/205 (43%)
		ABC_6TM_SUR1_D2_like	1475..1811	CDD:350046	88/343 (26%)
		TM helix 1	1475..1496	CDD:350046	4/20 (20%)
		TM helix 2	1520..1568	CDD:350046	11/49 (22%)
		TM helix 3	1575..1620	CDD:350046	13/44 (30%)
		TM helix 4	1621..1670	CDD:350046	18/48 (38%)
		TM helix 5	1682..1727	CDD:350046	16/50 (32%)
		TM helix 6	1777..1810	CDD:350046	10/32 (31%)
		ABCC_MRP_domain2	1980..2201	CDD:213211	104/220 (47%)
mrp-7	NP_507812.3	MRP_assoc_pro	14..1518	CDD:188098	505/2250 (22%)