Protein Alignment Sur and pgp-1

DIOPT Version :9

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_502413.1
• Gene: pgp-1 / 178215
• WormBaseID: WBGene00003995
• Length: 1321
• Species: Caenorhabditis elegans
• Alignment Length: 1977
• Identity: 363/1977 - (18%)
• Similarity: 627/1977 - (31%)
• Gaps: 854/1977 - (43%)

  Fly   369 IDKVRI-----YSSTWSDLLANGWCIAWIVLLAAITQGALSQASTHILNMTGIRIKTSLQGLI-- 426
            ::||.|     |::|...||      .:|..|.|:..||            |:.:.:.|||.:
 Worm    57 VNKVSIPQLYRYTTTLEKLL------LFIGTLVAVITGA------------GLPLMSILQGKVSQ 103

  Fly   427 --YRKSLLLNADGGC--------DSSD--------------------SAGQVQSTSSTSDEKQKN 461
              ..:.:::|.:|..        ..:|                    :|||:..|......:|.|
 Worm   104 AFINEQIVINNNGSTFLPTGQNYTKTDFEHDVMNVVWSYAAMTVGMWAAGQITVTCYLYVAEQMN 168

  Fly   462 DDSMATPEHVDNPSEPNIS----HDIGSITNHMTEDTRNIME-------------------FFLI 503
              :....|.|.:.....||    :..|::...:.::...:.|                   |.:.
 Worm   169 --NRLRREFVKSILRQEISWFDTNHSGTLATKLFDNLERVKEGTGDKIGMAFQYLSQFITGFIVA 231

  Fly   504 IHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFFIGNAMSKNAEVIAGYTDERL-- 566
            ..::|.:...:..|                       ||:|...|.|::|:....|  ..|.|
 Worm   232 FTHSWQLTLVMLAV-----------------------TPIQALCGFAIAKSMSTFA--IRETLRY 271

  Fly   567 ----KRIHDTLVGIK-VIKLNAWD---EVFLKKIQEARRK-ELKYLNKDATFWTLMAVLTHIATV 622
                |.:.:|:..|: |:.||...   |.:...::||::. .||.|....:|..:.| ...|:..
 Worm   272 AKAGKVVEETISSIRTVVSLNGLRYELERYSTAVEEAKKAGVLKGLFLGISFGAMQA-SNFISFA 335

  Fly   623 LITFVTLGVYVWLHRDQEFDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLK 687
            |..::.:|   |:|
 Worm   336 LAFYIGVG---WVH--------------------------------------------------- 346

  Fly   688 SSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNS 752
                    :|..|...:|:       .:.:....:|.:..|                .|:||
 Worm   347 --------DGSLNFGDMLT-------TFSSVMMGSMALGLA----------------GPQLA--- 377

  Fly   753 TPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRAR 817
              :|..|:.:|..|                 .|:|...|.:                      ..
 Worm   378 --VLGTAQGAASGI-----------------YEVLDRKPVI----------------------DS 401

  Fly   818 NTDSWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTS 882
            ::.:.|:|   :|:..||  ::.:..||:..:..:|:  |....:.|..|:...:||.:|.||::
 Worm   402 SSKAGRKD---MKIKGDI--TVENVHFTYPSRPDVPI--LRGMNLRVNAGQTVALVGSSGCGKST 459

  Fly   883 LLSALLMEMPLLAGNM-------------FWHKTCTISYVSQQPWLLNDTIRENILFGESFRPKR 934
            ::|.||....:|.|.:             |..|  .::.|||:|.|.|.||.|||..|:....:
 Worm   460 IISLLLRYYDVLKGKITIDGVDVRDINLEFLRK--NVAVVSQEPALFNCTIEENISLGKEGITR- 521

  Fly   935 YDFVLEACAL---KPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVVIMDDPLASL 996
             :.::.||.:   :..|:.:|.|..:::|:||..:||||:||||||||:..:..::::|:..::|
 Worm   522 -EEMVAACKMANAEKFIKTLPNGYNTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSAL 585

  Fly   997 DNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQPRIT 1061
            |.| .|.|.|..:.:..:  .||.|::..:|..|:.|:.:|:.|:|:|...|.:..:...|
 Worm   586 DAE-SEGIVQQALDKAAK--GRTTIIIAHRLSTIRNADLIISCKNGQVVEVGDHRALMAQQ---- 643

  Fly  1062 AEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACHADAIDGSGC 1126
                                                   ||...: ||...    ..||:|
 Worm   644 ---------------------------------------GLYYDL-VTAQT----FTDAVD---- 660

  Fly  1127 ISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMR 1191
                                    :|:.|.|:
 Worm   661 ------------------------SAAEGKFS--------------------------------- 668

  Fly  1192 PRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAESSVDGGDLAT 1256
              |.:::.|:                   |||
 Worm   669 --RENSVARQ-------------------TSE--------------------------------- 679

  Fly  1257 AAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPLDD---HVRG 1318
                              |:.|||.||.                           :||   .||.
 Worm   680 ------------------HEGLSRQASE---------------------------MDDIMNRVRS 699

  Fly  1319 SFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQSEEKPKK 1383
            |                           :|.||:  :.||
 Worm   700 S---------------------------TIGSIT--NGPV------------------------- 710

  Fly  1384 CVNIDSKETTINCDDNCYSASDKELRANVTSSPADQE--QHNERHVLAEVAGESGRESMPLARLA 1446
               ||.||..|..|  ..|...:||..|........|  .|...|.|:...|.|
 Worm   711 ---IDEKEERIGKD--ALSRLKQELEENNAQKTNLFEILYHARPHALSLFIGMS----------- 759

  Fly  1447 IDTERKYGKISDDIYLMYIRAAGLPIITIFFITALIWQCLRVYTDIWLQQWSNVHGRVASKGHVV 1511
                  ...|...||         |..::||.:                 :.||...
 Worm   760 ------TATIGGFIY---------PTYSVFFTS-----------------FMNVFAG-------- 784

  Fly  1512 LHPSE---QDHEVTYYFRMYAAISCVC-IIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHF 1572
             :|::   |.|.....|.:.||...:| .:|......|.:    :..|:|.:||.:.:|.:.:.|
 Worm   785 -NPADFLSQGHFWALMFLVLAAAQGICSFLMTFFMGIASE----SLTRDLRNKLFRNVLSQHIGF 844

  Fly  1573 FQVTP---LGRIVNRFSNDM----AVIDKKIAATGQRLLQFTLLCLSAILINVTITPW----ILV 1626
            |. :|   .|:|..|.:.|:    ..||.:.:.     :..||:.:.|.:.......|    :::
 Worm   845 FD-SPQNASGKISTRLATDVPNLRTAIDFRFST-----VITTLVSMVAGIGLAFFYGWQMALLII 903

  Fly  1627 LTLPIC--GAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFK 1689
            ..|||.  |.|...::|   :.:.::......:|..|:  .|.|:.|.|::|..::..|.|...:
 Worm   904 AILPIVAFGQYLRGRRF---TGKNVKSASEFADSGKIA--IEAIENVRTVQALAREDTFYENFCE 963

  Fly  1690 RLE-------------------ANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVTALTAASVSC 1735
            :|:                   |:::.| ||||....:|::|     .|....|:..:....|
 Worm   964 KLDIPHKEAIKEAFIQGLSYGCASSVLY-LLNTCAYRMGLAL-----IITDPPTMQPMRVLRV-- 1020

  Fly  1736 RRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMY 1800
                                .||:|.|.|.|       |.|.:|
 Worm  1021 --------------------MYAITISTSTL-------GFATSY--------------------- 1037

  Fly  1801 AGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTA 1865
                  ...||:                                                 ||.|
 Worm  1038 ------FPEYAK-------------------------------------------------ATFA 1047

  Fly  1866 AGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKV 1930
            .|.:        .|..|
 Worm  1048 GGII--------FGMLR------------------------------------------------ 1056

  Fly  1931 EQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQK 1995
                 |.|.|....|..::.....||:           :::|..::|:|.:|
 Worm  1057 -----KISKIDSLSLAGEKKKLYGKVI-----------FKNVRFAYPERPEI------------- 1092

  Fly  1996 QNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLS 2060
             .::..|:..:..||.:.:.|.:|.|||::...|.....|..|.|:||..:|:.:.|:..|::::
 Worm  1093 -EILKGLSFSVEPGQTLALVGPSGCGKSTVVALLERFYDTLGGEIFIDGSEIKTLNPEHTRSQIA 1156

  Fly  2061 IIPQDVHLFNATIREN----LDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLS 2121
            |:.|:..||:.:|.||    |||..... .|:.....||.:..|: ..||.|.:|.:.|.|..||
 Worm  1157 IVSQEPTLFDCSIAENIIYGLDPSSVTM-AQVEEAARLANIHNFI-AELPEGFETRVGDRGTQLS 1219

  Fly  2122 AGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDR 2186
            .|.:|.:.:|||::|....|:||||||.||:.:|..:.:|.|.|..|||.|.|||||.|:::.|.
 Worm  1220 GGQKQRIAIARALVRNPKILLLDEATSALDTESEKVVQEALDRAREGRTCIVIAHRLNTVMNADC 1284

  Fly  2187 LIVLDQGRIVEDGNPRELQQLEGSVFR 2213
            :.|:..|.|:|.|...:|...:|:.::
 Worm  1285 IAVVSNGTIIEKGTHTQLMSEKGAYYK 1311

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
pgp-1	NP_502413.1	PTZ00265	38..1311	CDD:240339	363/1975 (18%)
		ABC_membrane	81..367	CDD:279056	57/394 (14%)
		ABC_MTABC3_MDL1_MDL2	416..653	CDD:213216	74/291 (25%)
		ABC_membrane	760..1028	CDD:279056	65/345 (19%)
		ABC_MTABC3_MDL1_MDL2	1077..1316	CDD:213216	81/262 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000