DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sur and Abcc1

DIOPT Version :9

Sequence 1:	NP_001334732.1	Gene:	Sur / 34350	FlyBaseID:	FBgn0028675	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	NP_032602.1	Gene:	Abcc1 / 17250	MGIID:	102676	Length:	1528	Species:	Mus musculus

Alignment Length:	2256	Identity:	522/2256 - (23%)
Similarity:	825/2256 - (36%)	Gaps:	867/2256 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 FTFFSIFLLLFGLMFVCSRYKKCHKTLLTFHNGRAAISLLLLALNSFDLARIFLPHQNVRNLNRL 102
            |..:|.|.|.|   |..||:.:.:..:...:..:.|:...|..:...||...|
Mouse    44 FYLWSCFPLYF---FYLSRHDRGYIQMTHLNKTKTALGFFLWIICWADLFYSF------------ 93

  Fly   103 FQSSPRDLNYLVVIGSGELWNALFSTLLTLMLMLYHRMVERKKATVFLYASTAVEALTF------ 161
            ::.|...|...|::.|..|..      :|::|..:...:||:|..    .|:.: .|||
Mouse    94 WERSQGVLRAPVLLVSPTLLG------ITMLLATFLIQLERRKGV----QSSGI-MLTFWLVALL 147

  Fly   162 ---ALLSNELFELVR-------YED---FLELQTCLVAMSAMCMVSLAMLDGLTVYKECYHDDYL 213
               |:|.:::...::       :.|   :|.....||.:...|....:.|     :.|..||
Mouse   148 CALAILRSKIISALKKDAHVDVFRDSTFYLYFTLVLVQLVLSCFSDCSPL-----FSETVHD--- 204

  Fly   214 DDYGKIGYKHSMATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSA--------------- 263
                :.....|.|:|.|:..|||:|.::..||::|||..||..:..||::
Mouse   205 ----RNPCPESSASFLSRITFWWITGMMVHGYRQPLESSDLWSLNKEDTSEEVVPVLVNNWKKEC 265

  Fly   264 -RSHYDHFLYIYTEKK---KKSNSS---------------------PSLWYCYIKNSWQMFALGG 303
             :|.......:|...|   |...||                     |||:....|.....|.:..
Mouse   266 DKSRKQPVRIVYAPPKDPSKPKGSSQLDVNEEVEALIVKSPHKDREPSLFKVLYKTFGPYFLMSF 330

  Fly   304 ILKLAGDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVANVLLSTSRILGTEFDEVFGTN 368
            :.|...||....||..::.|:.::..     .|.|
Mouse   331 LYKALHDLMMFAGPKILELIINFVND-----REAP------------------------------ 360

  Fly   369 IDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTHILNMTGIRIKTSLQGLIYRKSLLL 433
                     .|     .|:....::.::|..|........||..::|:||||::.|.:|||:||:
Mouse   361 ---------DW-----QGYFYTALLFVSACLQTLALHQYFHICFVSGMRIKTAVVGAVYRKALLI 411

  Fly   434 NADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISHDIGSITNHMTEDTRNIM 498
            .         :|.:..||                               :|.|.|.|:.|.:..|
Mouse   412 T---------NAARKSST-------------------------------VGEIVNLMSVDAQRFM 436

  Fly   499 EFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFFIGNAMSKNAEVIAGY-- 561
            :....|:..|:.|.::.:.:|.|:::||.| |:..:|.:::|.||...:  ||......:|..
Mouse   437 DLATYINMIWSAPLQVILALYFLWLSLGPS-VLAGVAVMILMVPLNAVM--AMKTKTYQVAHMKS 498

  Fly   562 TDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELKYLNKDATFWTLMAVLTHIAT-VLIT 625
            .|.|:|.:::.|.||||:||.||:..|..|:...|::|||.|.|.| :...:...|.:.| .|:.
Mouse   499 KDNRIKLMNEILNGIKVLKLYAWELAFQDKVMSIRQEELKVLKKSA-YLAAVGTFTWVCTPFLVA 562

  Fly   626 FVTLGVYVWLHRDQEFDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSE 690
            ..|..|:|.:  |:...|:|.:.|.|||||..|..||.|.|:.:..|:.|.||.:||..||
Mouse   563 LSTFAVFVTV--DERNILDAKKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFL---- 621

  Fly   691 IQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPL 755

Mouse   622 ----------------------------------------------------------------- 621

  Fly   756 LQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTD 820
                  |.|::.|.:::
Mouse   622 ------SHEELEPDSIE------------------------------------------------ 632

  Fly   821 SWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMPVVQLHVPGII--VPKGKLTIVVGKNGSGKTSL 883
              ||.   :|..:..::::.:..||| .:.:.|.:.    ||.  :|:|.|..|||:.|.||:||
Mouse   633 --RRS---IKSGEGNSITVKNATFTW-ARGEPPTLN----GITFSIPEGALVAVVGQVGCGKSSL 687

  Fly   884 LSALLMEMPLLAGNMFWHKTC--TISYVSQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKP 946
            |||||.||..:.|    |.|.  :::||.||.|:.||::|||||||...:...|..|:|||||.|
Mouse   688 LSALLAEMDKVEG----HVTLKGSVAYVPQQAWIQNDSLRENILFGHPLQENYYKAVMEACALLP 748

  Fly   947 DIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIRE 1011
            |:|::|.||.:.|||:|:|:||||:||:::|||:||::::.:.||||:::|..||:|||:..:..
Mouse   749 DLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNSDIYLFDDPLSAVDAHVGKHIFEKVVGP 813

  Fly  1012 MLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKND 1076
            |....|:|.||||..:..:.:.:.:|.:..|::...|||.::
Mouse   814 MGLLKNKTRILVTHGISYLPQVDVIIVMSGGKISEMGSYQEL----------------------- 855

  Fly  1077 NPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACHADAIDGSGCI-----SVANMQSNV 1136
                                                        :|..|..     :.||.:.::
Mouse   856 --------------------------------------------LDRDGAFAEFLRTYANAEQDL 876

  Fly  1137 VEEDDQVS----VSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHT 1197
            ..|||.||    .|.|:.|..                  |:.|                     |
Mouse   877 ASEDDSVSGSGKESKPVENGM------------------LVTD---------------------T 902

  Fly  1198 LGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAESSVDGGDLATAAPEPR 1262
            :|:...|:               .|.|||.|||        ||
Mouse   903 VGKHLQRH---------------LSNSSSHSGD--------TS---------------------- 922

  Fly  1263 VQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRM 1327
                  .||
Mouse   923 ------QQH-------------------------------------------------------- 925

  Fly  1328 SMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKET 1392
                                 .||:|            |...|.|.||.      |.:..|..:|
Mouse   926 ---------------------SSIAE------------LQKAGAKEETW------KLMEADKAQT 951

  Fly  1393 TINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKIS 1457
                                                                         |::.
Mouse   952 -------------------------------------------------------------GQVQ 955

  Fly  1458 DDIYLMYIRAAGLPIITIFFITALIWQCLRV---YTDIWLQQWSN----VHGRVASKGHVVLHPS 1515
            ..:|..|::|.||   .|.|::..::.|..|   .::.||..|::    |:|..|::.
Mouse   956 LSVYWNYMKAIGL---FITFLSIFLFLCNHVSALASNYWLSLWTDDPPVVNGTQANRN------- 1010

  Fly  1516 EQDHEVTYYFRM--YAAISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPL 1578
                     ||:  |.|:..:........:.|....|..|.|.||..||..:|...:.||:.||.
Mouse  1011 ---------FRLSVYGALGILQGAAIFGYSMAVSIGGIFASRRLHLDLLYNVLRSPMSFFERTPS 1066

  Fly  1579 GRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVTITPWILVLTLPICGAYYLIQKFYR 1643
            |.:|||||.::..:|..|....:..:......:.|::|.:..||...|:..|:...|:.:|:||.
Mouse  1067 GNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYFFVQRFYV 1131

  Fly  1644 CSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWL 1708
            .|:|:|:|:|:.:.|||.||.:||:.||:.||||.:|.||......:::.|..||.....::|||
Mouse  1132 ASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWL 1196

  Fly  1709 GVSLDYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLV 1773
            .|.|:.:|.|||..|.:.|:.:      ||       |.||                     .||
Mouse  1197 AVRLECVGNCIVLFAALFAVIS------RH-------SLSA---------------------GLV 1227

  Fly  1774 GLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSS 1838
            ||:::|:|.:..||||:|::.::||....:|||:..|::
Mouse  1228 GLSVSYSLQITAYLNWLVRMSSEMETNIVAVERLKEYSE-------------------------- 1266

  Fly  1839 NEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANAD 1903

Mouse  1267 ----------------------------------------------------------------- 1266

  Fly  1904 KLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLER 1968
                                                 .:|:.|.|..:
Mouse  1267 -------------------------------------TEKEAPWQIQE----------------- 1277

  Fly  1969 YQSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVL 2033
             .:.|.:||..|.:.|.:..|||......|:.::.:.|..|:::||.||||:|||||.|.||.:.
Mouse  1278 -TAPPSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRIN 1341

  Fly  2034 QTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLK 2098
            ::..|.|.||.|:|.:|....||.:::|||||..||:.::|.||||...:.|.::|..||||.||
Mouse  1342 ESAEGEIIIDGVNIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLK 1406

  Fly  2099 EFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAAD 2163
            .||:. ||..|:....:||.|||.|.|||:|||||:||.:..|||||||:.:|..|::.:.....
Mouse  1407 GFVSA-LPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIR 1470

  Fly  2164 LAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEG 2209
            ..|...|::||||||.||:||.|:||||:|.:.|.|.|.||.|..|
Mouse  1471 TQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEVRECGAPSELLQQRG 1516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
Abcc1	NP_032602.1	MRP_assoc_pro	7..1527	CDD:188098	522/2256 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	876..895		7/18 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	909..929		13/147 (9%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110