DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sur and Abcc2

DIOPT Version :9

Sequence 1:	NP_001334732.1	Gene:	Sur / 34350	FlyBaseID:	FBgn0028675	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	NP_038834.2	Gene:	Abcc2 / 12780	MGIID:	1352447	Length:	1543	Species:	Mus musculus

Alignment Length:	2244	Identity:	501/2244 - (22%)
Similarity:	807/2244 - (35%)	Gaps:	841/2244 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 SRYKKCHKTLLTFHNGRAAISLLLLALNSFDLARIFLPHQNVRNLNRLFQSSPRDLNYLVVIGSG 119
            ||.|:.  .:..|:..:....:.||.|.:.||:...........:..:..::|  :.||..
Mouse    53 SRTKRF--AITKFYLAKQVFVVCLLILAAIDLSLALTEDTGQATIPPVKYTNP--ILYLCT---- 109

  Fly   120 ELWNALFSTLLTLMLMLYH-RMVERKKATVFL-------------YASTAVEALTFALLSNELFE 170
              |        .|:|::.| |....:|.:.||             ...|.:.||.....||..:
Mouse   110 --W--------LLVLVIQHCRQCCIQKNSWFLSMFWILSLLCGIFQFQTLIRALLQDSKSNMTY- 163

  Fly   171 LVRYEDFLELQTCLVAMSAMCMVSLAMLDGLTVYKECYHDDYLDDYGKIGYKHSMATFYSKSCFW 235
                       :||..:|....:.:.:|...:...:..|           ...:.|:|.|...|.
Mouse   164 -----------SCLFFVSYGFQIVILILSAFSESSDSTH-----------APSATASFLSSVTFS 206

  Fly   236 WLTPLLWLGYKEPLELEDLGQMKLEDSARSHYDHFLYIYT------------------------- 275
            |....:..|||.||.:||:..::....|:|....|..|.|
Mouse   207 WYDSTVLKGYKHPLTIEDVWDIEENLKAKSLTSKFKTIMTKDLQKARQALQRRLKKSQQSPEGTS 271

  Fly   276 --------------------EKKKKSNSS---PSLWY--CYIKNSWQMFALGGILKLAGDLFALI 315
                                :|||||.::   |..|.  ...|..:.:.....|||||.|:...:
Mouse   272 HGLTKKQSQSQDVLVLEDSKKKKKKSEATKDFPKSWLVKALFKTFYVVILKSFILKLAHDILLFL 336

  Fly   316 GPLAIQKIVEYIEQLYAQASEPPAKSPGNEVANVLLSTSRILGTEFDEVFGTNIDKVRIYSSTWS 380
            .|..::.::.::            |.|.                                |..|.
Mouse   337 NPQLLKFLIGFV------------KDPD--------------------------------SYPWV 357

  Fly   381 DLLANGWCIAWIVLLAAITQGALSQASTHILNMTGIRIKTSLQGLIYRKSLLLNADGGCDSSDSA 445
                 |:..|.::....:.|....|.......:.|:.::|::...:|:|:|.|:
Mouse   358 -----GYIYAILMFSVTLIQSFFLQCYFQFCFVLGMTVRTTIIASVYKKALTLS----------- 406

  Fly   446 GQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISHDIGSITNHMTEDTRNIMEFFLIIHYAWAI 510
                              ::|..::.           ||...|.|:.|::.:|:....||..|:.
Mouse   407 ------------------NLARRQYT-----------IGETVNLMSVDSQKLMDVTNYIHLLWSS 442

  Fly   511 PFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVG 575
            ..:||:.|:.|:..||.| ::..:..:|::.|:...:...:.|.........|:|||.:::.|.|
Mouse   443 VLQIALSIFFLWRELGPS-ILAGVGLMVLLVPVNGVLATKIRKIQVQNMKNKDKRLKIMNEILSG 506

  Fly   576 IKVIKLNAWDEVFLKKIQEARRKELKYLNKDATFWTLMAVLTHIATVLITFVTLGVYVWLHRDQE 640
            ||::|..||:..|.:::...|:|||:.|.:.:...|::..:.|:...|::.:|..|||.:  |.:
Mouse   507 IKILKYFAWEPSFKEQVNSIRKKELRNLLRFSQLQTILIFILHLTPTLVSVITFSVYVLV--DSQ 569

  Fly   641 FDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARIL 705
            ..|||.:.|:|:.||..|..||.:.|:.:..:|.|.||..|||::|.|
Mouse   570 NVLNAEKAFTSITLFNILRFPLAMLPMVISSVIQASVSVDRLEQYLGS----------------- 617

  Fly   706 SKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPST 770
                                                                      :|:..|.
Mouse   618 ----------------------------------------------------------DDLDLSA 624

  Fly   771 VQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDI 835
            ::.:.|                            .::.|:||
Mouse   625 IRHVCH----------------------------FDKAVQFS----------------------- 638

  Fly   836 AVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFW 900
                 :..|||....:..:..:::.   :..|:|..|||..||||:||:||:|.||.    |:..
Mouse   639 -----EASFTWDRDLEATIQDVNLD---IKPGQLVAVVGTVGSGKSSLISAMLGEME----NVHG 691

  Fly   901 HKTC--TISYVSQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERG 963
            |.|.  :|:||.||.|:.|.||::|||||..:..|:|..|:|||||.||:|::|.||::.|||:|
Mouse   692 HITIKGSIAYVPQQAWIQNGTIKDNILFGSEYDEKKYQRVIEACALLPDLEMLPGGDMAEIGEKG 756

  Fly   964 INISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLH 1028
            ||:||||:.|:::|||.|..|::.|:||||:::|..||:|||...:......|.:|.||||..:|
Mouse   757 INLSGGQKHRVSLARATYQDADIYILDDPLSAVDTHVGKHIFNKVVGPNGLLSGKTRILVTHGIH 821

  Fly  1029 RIKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKL 1093
            .:.:.:.::.:..|.:...|||:|:...:......|...:     |:..|.   ||.|.
Mouse   822 FLPQVDEIVVLGKGTILEKGSYSDLMDKKGVFAKNWKTFM-----KHSGPE---GEATV------ 872

  Fly  1094 LKNVSKLGLQRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFN 1158
                                                    .|..||:|          ..||
Mouse   873 ----------------------------------------DNDSEEED----------GDCG--- 884

  Fly  1159 LQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSE 1223
                            .:| .::|...|...:..||.::|.|                ||:.:|.
Mouse   885 ----------------LIP-TVEEIPDDAASLTMRRENSLRR----------------TLSRSSR 916

  Fly  1224 SSSISGDVLSRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAM 1288
            |.|..|..|..|:...|.::
Mouse   917 SGSRRGKSLKSSLKIKSVNA--------------------------------------------- 936

  Fly  1289 EVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISE 1353
                  :.|.||.              |:|
Mouse   937 ------LNKKEEV--------------VKG----------------------------------- 946

  Fly  1354 ESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPAD 1418
                                        :|.:..:..||
Mouse   947 ----------------------------QKLIKKEFVET-------------------------- 957

  Fly  1419 QEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAG---LPIITIFFITA 1480
                                               ||:...|||.|::|.|   |..|.||::..
Mouse   958 -----------------------------------GKVKFSIYLKYLQAVGWWSLLFIVIFYVLN 987

  Fly  1481 LIWQCLRVYTDIWLQQWSNVHGRVASKGHVVLHPSEQDHEVTYYFRMYAAISCVCIIMALVSTPA 1545
            .:   ..:.|::||..|::...:.....:   .||::|..:    .::.|:.....|..|.|:..
Mouse   988 YV---AFIGTNLWLSAWTSDSEKQNGTDN---SPSQRDMRI----GVFGALGIAQGIFLLSSSLW 1042

  Fly  1546 GQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLC 1610
            ..||..||.:.||.:||..||...:.||..||.|||||||:.|::.:|..:..|    |:..|||
Mouse  1043 SIYACRNASKTLHRQLLTNILRAPMSFFDTTPTGRIVNRFAGDISTVDDTLPQT----LRSWLLC 1103

  Fly  1611 ----LSAILINVTITPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGV 1671
                :|.:::....||..:::.:|:...|..:|.||..::|:|:|:::.|.||:.||.|||:.|:
Mouse  1104 FFGIVSTLVMICMATPIFIIIIIPLSILYVSVQVFYVATSRQLRRLDSVTKSPIYSHFSETVSGL 1168

  Fly  1672 TTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVATV------TALTA 1730
            ..||||..|.||.....|:::.|........||:|||.:.|:.:|..|||.:.:      .:||.
Mouse  1169 PVIRAFEHQQRFLANSEKQIDTNQKCVFSWITSNRWLAIRLELVGNLIVFCSALLLVIYKNSLTG 1233

  Fly  1731 ASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLA 1795
                                                    ..||..::..|.:...|||:|::.:
Mouse  1234 ----------------------------------------DTVGFVLSNALNITQTLNWLVRMTS 1258

  Fly  1796 DMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYP 1860
            ::|....:||||..|                   .::|:|.                       |
Mouse  1259 EVETNIVAVERINEY-------------------INVDNEA-----------------------P 1281

  Fly  1861 GATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPAT 1925
            ..|
Mouse  1282 WVT-------------------------------------------------------------- 1284

  Fly  1926 AGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLR 1990
                                       |||                .|..||::|:|.|:|..:|
Mouse  1285 ---------------------------DKK----------------PPADWPKKGEIQFNNYQVR 1306

  Fly  1991 YEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDEL 2055
            |..:...|:..:|..|.:.:::|:.||||:|||||...||.:|::..|.|.||.:||..|...:|
Mouse  1307 YRPELDLVLKGITCNIKSTEKVGVVGRTGAGKSSLTNCLFRILESAGGQIIIDGIDIASIGLHDL 1371

  Fly  2056 RTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNL 2120
            |.||:|||||..||:..:|.||||...:.|.::|..||||.||.||.| |.|||...:.:||.||
Mouse  1372 RGRLTIIPQDPILFSGNLRMNLDPFNKYSDEEIWRALELAHLKSFVAG-LQLGLLHEVTEGGDNL 1435

  Fly  2121 SAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYD 2185
            |.|.||||||.||:||.|..|||||||:.:|..|:|.:.......|...|:|||||||.||:|.|
Mouse  1436 SIGQRQLLCLGRAVLRKSKILVLDEATAAVDLETDSLIQTTIRNEFSQCTVITIAHRLHTIMDSD 1500

  Fly  2186 RLIVLDQGRIVEDGNPRELQQLEGSVFRGLLEKG 2219
            :::|||.|:|||.|:|.||....|..:....|.|
Mouse  1501 KIMVLDSGKIVEYGSPEELLSNMGPFYLMAKEAG 1534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
Abcc2	NP_038834.2	MRP_assoc_pro	10..1535	CDD:188098	501/2244 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..285		0/24 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	903..927		10/39 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.110