Protein Alignment Sur and LOC1277037

DIOPT Version :10

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: XP_061498966.1
• Gene: LOC1277037 / 1277037
• VectorBaseID: AGAMI1_013916
• Length: 1421
• Species: Anopheles gambiae
• Alignment Length: 2016
• Identity: 480/2016 - (23%)
• Similarity: 778/2016 - (38%)
• Gaps: 677/2016 - (33%)

  Fly   226 ATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSARSHYDHFLYIYTEKKKKS---NSSPSL 287
            |.|.|...|.|..|:.:.|||:.|..:||.|...|..:....|.....:..::|::   |..|.|
Mosquito    17 ANFLSYIIFGWTIPIFFKGYKKELNTDDLYQPLREHKSDGLGDRLCEAWENEQKQARMKNRKPKL 81

  Fly   288 WYCYIK-NSWQMFALGGILKLAGDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVANVLL 351
            .....: ..|::..||.:|.....||.:..|..:.|:|.|.
Mosquito    82 LRAGFRVFGWEIALLGLVLLTLEMLFKVSQPFFLGKLVAYY------------------------ 122

  Fly   352 STSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAIT-----QGALSQASTHIL 411
              ||..|         :|.:..:|:..             :||.:||.     ...|||  .|:
Mosquito   123 --SRQQG---------DITEAYLYAGA-------------VVLCSAINVLFIHPYMLSQ--LHL- 160

  Fly   412 NMTGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSE 476
               |::::.:...:||||||.|:.....|:  :||||.:.
Mosquito   161 ---GMKLRVAACSMIYRKSLRLSKTALGDT--TAGQVVNL------------------------- 195

  Fly   477 PNISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMT 541
              :|:|:|.:...:           |.:||.|..|.:..||.||:|..:|.||:.| :..:::..
Mosquito   196 --LSNDVGRLDLAV-----------LFVHYLWIGPLETLVVTYLMYREIGYSAIYG-VLFLLLFI 246

  Fly   542 PLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELKYLNKD 606
            |||.::|...|:.....|..||||::.:::.:.||:|||:..|:..|...:..||:||:|
Mosquito   247 PLQAYLGKKTSELRLRTALRTDERVRLMNEIIQGIQVIKMYTWERPFAALVAMARKKEIK----- 306

  Fly   607 ATFWTLMAVLTHIATVLITFV--TLGVYVWLH------RDQEFDLNASRLFSSLALFQQL-TVPL 662
                 ::..:::|..:|::|:  |..|.::|.      ..|.  :.|.:.|:..|.:..| |...
Mosquito   307 -----VIRYVSYIRGILLSFIMFTTRVSIFLSLVAYALAGQV--VTAEKAFAITAYYNILRTTMT 364

  Fly   663 LIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRT 727
            :.||..:.....|.||.||:::|::..||:.. ||: :|.....|..:|....:.|||
Mosquito   365 IFFPQGIGQFAEALVSVRRIQKFMQYDEIESA-EGV-SMVGGDGKDASSSSSSDLQEK------- 420

  Fly   728 AQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPY 792
                          |.....||..::..::::|..... .|:.|....|    ||:..|
Mosquito   421 --------------KPDADPLALPNSKFIRHSESDGLK-EPAAVNNHHH----QQQHHL------ 460

  Fly   793 VAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMPVVQL 857
                  ...|.::|:.|      ||    |...:..|.:         ||            |.|
Mosquito   461 ------SDAGVIVEKAV------AR----WDAKATELTL---------DG------------VDL 488

  Fly   858 HV-PGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTISYVSQQPWLLNDTIR 921
            || ||.:|      .|:|..|:||:||:.|:|.|:||.:|::  .....:||.||:|||.:.|:|
Mosquito   489 HVQPGTLV------AVIGPVGAGKSSLIHAILGELPLESGSI--KVNGNVSYASQEPWLFSGTVR 545

  Fly   922 ENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANV 986
            :|||||.....:||..|::.|||:.|..|...||.:|:||||:::||||:.||::|||:|..|.|
Mosquito   546 QNILFGLPMDRERYKQVVKTCALERDFHLFADGDKTIVGERGVSLSGGQKARISLARAVYRRAEV 610

  Fly   987 VIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYA 1051
            .::||||:::|:.||.|:|.||:|:.|:  .:..||||.||..::.|:.::.:..|||||.|:|.
Mosquito   611 YLLDDPLSAVDSHVGRHLFDHCMRDYLR--GKIVILVTHQLQYLQNADQIVVMMHGRVEAVGTYD 673

  Fly  1052 DIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVAC 1116
            .:.    ....::..::|....:.|:.:.....|.:|..:|          :::...:||:.||
Mosquito   674 KLR----ESGQDFAQLLAAPSGREDDSTDTESIKRSGSLYK----------RQNSESSMDSAVA- 723

  Fly  1117 HADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPID 1181
                 ||.|      .::..:||                    ::|..||      .|||.....
Mosquito   724 -----DGEG------PEAKAIEE--------------------RQKEGSI------GYDVYRAYF 751

  Fly  1182 ECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAE 1246
            ...|.::::                                             ||.......::
Mosquito   752 RASGGNLVV---------------------------------------------VLILFMFLLSQ 771

  Fly  1247 SSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESP 1311
            .|..|||..       :..|                            |.|:||...:.|..:.
Mosquito   772 LSASGGDYF-------LTYW----------------------------VNKAEEKAPAATGGDG- 800

  Fly  1312 LDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQ 1376
                                           .|..::.              |.||
Mosquito   801 -------------------------------GAAGAMF--------------SALA--------- 811

  Fly  1377 SEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMP 1441
                                     :||.:|.....|..|                        |
Mosquito   812 -------------------------NASAEEFNETTTFEP------------------------P 827

  Fly  1442 LARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFITALIWQCLRVYTDIWLQQWSNVHGRVAS 1506
            ....|:.|                .|.|:.:    |.||:                    .::.:
Mosquito   828 AVTTAVTT----------------GAGGIGV----FFTAI--------------------RQMFA 852

  Fly  1507 KGHVVLHPSEQDHEVTYYFRMYAAISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLH 1571
            .|     ..|:|..:..|  ::.|::...:::.|..:.........|.|.|||.:...|...:::
Mosquito   853 SG-----DEEEDRYIDIY--IFTALTVATVVITLTRSMFFFRTAMKASRKLHDAMFNGITRASMY 910

  Fly  1572 FFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVTITPWILVLTLPICGAYY 1636
            ||...|.|||:||||.||..||:.:.:....::|..|..:..:::...:.|:.|:.|:.|...:|
Mosquito   911 FFNTNPSGRILNRFSKDMGQIDEYLPSVTVDVIQIFLSLIGIVVVVAIVNPYNLIPTVVIGIIFY 975

  Fly  1637 LIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALL 1701
            .::.||..::|.::|:|..|.||:.||||.::.|::|||||..:...........:.::.|:.|.
Mosquito   976 FMRAFYLLTSRNIKRVEAITRSPIYSHLSASLSGLSTIRAFGAEKVLVHEFDSHQDLHSSAFYLF 1040

  Fly  1702 NTSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSEL 1766
            .::.|..|..||..  |::::|.||.                            |:.:...
Mosquito  1041 ISTSRAFGFYLDVF--CVIYIAIVTL----------------------------TFFIRGD---- 1071

  Fly  1767 RPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADADADVDAD 1831
              |...|||||...|.:...:.|.::..|::|....||||:..|
Mosquito  1072 --SGGNVGLAITQALGMTGMVQWGMRQSAELENTMTSVERVVEY--------------------- 1113

  Fly  1832 LDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHEN 1896
                                    |.|.|                                  |.
Mosquito  1114 ------------------------DNVDP----------------------------------EP 1120

  Fly  1897 GAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNE 1961
            ..||.|||                                        .||::
Mosquito  1121 ALEAPADK----------------------------------------KPPKE------------ 1133

  Fly  1962 PARKLERYQSVPISWPQRGDIHFDNVSLRY--EGQKQNVISNLTLKIPAGQRIGICGRTGSGKSS 2024
                          |||.|.|.|:.|:|||  :.....|:.:|..:|...::|||.||||:||||
Mosquito  1134 --------------WPQEGRIRFEKVTLRYSPDADSDLVLRDLQFEIEPREKIGIVGRTGAGKSS 1184

  Fly  2025 LGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLW 2089
            |..:||. |....|.|.||..|..::...:||.:||||||:..||:.|:|.||||...:.|.:||
Mosquito  1185 LINALFR-LSYNGGSILIDTRDTSQMGLHDLRAKLSIIPQEPVLFSGTLRYNLDPFDEYPDEKLW 1248

  Fly  2090 NCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSST 2154
            ..|:..:|::.|| .||.||.:.|.:||.|.|.|.|||:||||||||.:..||:||||:.:|..|
Mosquito  1249 RALKEVKLEDAVN-ELPSGLSSKINEGGSNFSVGQRQLVCLARAILRENKILVMDEATANVDPQT 1312

  Fly  2155 ESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEG--SVFRGLLE 2217
            :..:.:.....|...|::||||||.|::|.|:::|:|.||.||.|.|.||...||  .||.|:::
Mosquito  1313 DKLIQQTIREKFNDCTVLTIAHRLNTVMDSDKVLVMDAGRCVEFGTPYELLTTEGGPKVFYGMVK 1377

  Fly  2218 K 2218
            :
Mosquito  1378 Q 1378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	ABC_6TM_SUR1_D1_like	301..682	CDD:350035	92/394 (23%)
		TM helix 1	301..324	CDD:350035	7/22 (32%)
		TM helix 2	385..433	CDD:350035	15/52 (29%)
		TM helix 3	480..525	CDD:350035	13/44 (30%)
		TM helix 4	526..575	CDD:350035	14/48 (29%)
		TM helix 5	587..631	CDD:350035	10/45 (22%)
		TM helix 6	648..681	CDD:350035	9/33 (27%)
		ABCC_MRP_domain1	837..1043	CDD:213217	83/206 (40%)
		ABC_6TM_SUR1_D2_like	1475..1811	CDD:350046	79/335 (24%)
		TM helix 1	1475..1496	CDD:350046	3/20 (15%)
		TM helix 2	1520..1568	CDD:350046	9/47 (19%)
		TM helix 3	1575..1620	CDD:350046	14/44 (32%)
		TM helix 4	1621..1670	CDD:350046	17/48 (35%)
		TM helix 5	1682..1727	CDD:350046	9/44 (20%)
		TM helix 6	1777..1810	CDD:350046	9/32 (28%)
		ABCC_MRP_domain2	1980..2201	CDD:213211	100/222 (45%)
LOC1277037	XP_061498966.1	None