DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sur and ABCC2

DIOPT Version :9

Sequence 1:NP_001334732.1 Gene:Sur / 34350 FlyBaseID:FBgn0028675 Length:2223 Species:Drosophila melanogaster
Sequence 2:NP_000383.2 Gene:ABCC2 / 1244 HGNCID:53 Length:1545 Species:Homo sapiens


Alignment Length:2246 Identity:507/2246 - (22%)
Similarity:801/2246 - (35%) Gaps:847/2246 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   100 NRLFQSSPR-DL------NYLVVIGSGELWNALFSTLLTLMLMLYHRMVERKKATVFLYASTAV- 156
            |..|..||. ||      ..||.|..|.||     .|....|:..::...::.:|..||.:..| 
Human    12 NSSFLDSPEADLPLCFEQTVLVWIPLGYLW-----LLAPWQLLHVYKSRTKRSSTTKLYLAKQVF 71

  Fly   157 -------EALTFALLSNE-----LFELVRYED-FLELQTCLVAM-----SAMCMVS--------- 194
                   .|:..||:..|     ....|||.: .|.|.|.|:.:     ...|:..         
Human    72 VGFLLILAAIELALVLTEDSGQATVPAVRYTNPSLYLGTWLLVLLIQYSRQWCVQKNSWFLSLFW 136

  Fly   195 -LAMLDGLTVYKECYHDDYLDDYGKIGYK-----------------------------HSMATFY 229
             |::|.|...::.........|...:.|.                             .|:|:|.
Human   137 ILSILCGTFQFQTLIRTLLQGDNSNLAYSCLFFISYGFQILILIFSAFSENNESSNNPSSIASFL 201

  Fly   230 SKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSARSHYDHF------------------------ 270
            |...:.|...::..|||.||.|||:.::..|...::....|                        
Human   202 SSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHMKRELQKARRALQRRQEKSSQ 266

  Fly   271 ----------------------LYIYTEKKKKSNSSPSLWYCYIKNSWQMFAL----------GG 303
                                  |....:|||||.:...     :..||.|.||          ..
Human   267 QNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKD-----VPKSWLMKALFKTFYMVLLKSF 326

  Fly   304 ILKLAGDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVANVLLSTSRILGTEFDEVFGTN 368
            :|||..|:|..:.|                           ::..:|:|                
Human   327 LLKLVNDIFTFVSP---------------------------QLLKLLIS---------------- 348

  Fly   369 IDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTHILNMTGIRIKTSLQGLIYRKSLLL 433
                  ::|.....|..|:..|.::..||:.|....|....:....|::::|::...:|:|:|.|
Human   349 ------FASDRDTYLWIGYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTL 407

  Fly   434 NADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISHDIGSITNHMTEDTRNIM 498
            :                             ::|..|:.           :|...|.|:.|.:.:|
Human   408 S-----------------------------NLARKEYT-----------VGETVNLMSVDAQKLM 432

  Fly   499 EFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFFIGNAMSKNAEV-IAGYT 562
            :....:|..|:...:|.:.|:.|:..||.| |:..:..:|::.|:...: :..||..:| .....
Human   433 DVTNFMHMLWSSVLQIVLSIFFLWRELGPS-VLAGVGVMVLVIPINAIL-STKSKTIQVKNMKNK 495

  Fly   563 DERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELKYLNKDATFWTLMAVLTHIATVLITFV 627
            |:|||.:::.|.|||::|..||:..|..::|..|:||||.|...:....::..:..:..||::.|
Human   496 DKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVV 560

  Fly   628 TLGVYVWLHRDQEFDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQ 692
            |..|||.:  |....|:|.:.|:|:.||..|..||.:.|:.:..::.|.|||.|||::|      
Human   561 TFSVYVLV--DSNNILDAQKAFTSITLFNILRFPLSMLPMMISSMLQASVSTERLEKYL------ 617

  Fly   693 KQFEGIRNMARILSKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQ 757
                                                                             
Human   618 ----------------------------------------------------------------- 617

  Fly   758 NAEESAEDISPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSW 822
                ..:|:..|.:                                                   
Human   618 ----GGDDLDTSAI--------------------------------------------------- 627

  Fly   823 RRDSLLLKMPDDIAVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSAL 887
            |.|...     |.|:..::..|||:..|:..|..:::.   :..|:|..|:|..||||:||:||:
Human   628 RHDCNF-----DKAMQFSEASFTWEHDSEATVRDVNLD---IMAGQLVAVIGPVGSGKSSLISAM 684

  Fly   888 LMEMPLLAGNMFWHKTC--TISYVSQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIEL 950
            |.||.    |:..|.|.  |.:||.||.|:.|.||::|||||..|..|||..|||||||.||:|:
Human   685 LGEME----NVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEM 745

  Fly   951 MPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQK 1015
            :|.|||:.|||:|||:||||:|||::|||.|.:.::.::||||:::|..||:|||...:......
Human   746 LPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLL 810

  Fly  1016 SNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQ 1080
            ..:|.:|||..:|.:.:.:.::.:.:|.:...|||              :|::|           
Human   811 KGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSY--------------SALLA----------- 850

  Fly  1081 NPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSV 1145
                 ..||..|.||.     ..|......:|.|  |    |||            .||||.   
Human   851 -----KKGEFAKNLKT-----FLRHTGPEEEATV--H----DGS------------EEEDDD--- 884

  Fly  1146 SYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSH 1210
                                        |.:...::|...|...:..||.::..|..||::.|:.
Human   885 ----------------------------YGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNG 921

  Fly  1211 RLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHH 1275
            |                                                                
Human   922 R---------------------------------------------------------------- 922

  Fly  1276 QPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHH 1340
                                                   |::          |:|.|.|.:|   
Human   923 ---------------------------------------HLK----------SLRNSLKTRN--- 935

  Fly  1341 PLSATNSILSISEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASD 1405
                .||:                        .|.:...|.:|.:..:..||             
Human   936 ----VNSL------------------------KEDEELVKGQKLIKKEFIET------------- 959

  Fly  1406 KELRANVTSSPADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAGL 1470
                                                            ||:...|||.|::|.||
Human   960 ------------------------------------------------GKVKFSIYLEYLQAIGL 976

  Fly  1471 PIITIFF-ITALIWQCLR-VYTDIWLQQWSNVHGRVASKGHVVLHPSEQDHEVTYYFRMYAAISC 1533
              .:||| |.|.:...:. :.:::||..|::......|..:..   |::|..|    .:|.|:..
Human   977 --FSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPA---SQRDMRV----GVYGALGL 1032

  Fly  1534 VCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAA 1598
            ...|...::.....:...:|...||.:||..||...:.||..||.|||||||:.|::.:|..:..
Human  1033 AQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQ 1097

  Fly  1599 TGQRLLQFTLLCLSAILINVTITPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISH 1663
            :.:..:...|..:|.:::....||...::.:|:...|..:|.||..::|:|:|:::.|.||:.||
Human  1098 SLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSH 1162

  Fly  1664 LSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVTAL 1728
            .|||:.|:..||||..|.||.:....|::.|........||:|||.:.|:.:|...||.:.:..:
Human  1163 FSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMMV 1227

  Fly  1729 TAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKL 1793
            .         |..|.|...                         ||..::..|.:...|||:|::
Human  1228 I---------YRDTLSGDT-------------------------VGFVLSNALNITQTLNWLVRM 1258

  Fly  1794 LADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKV 1858
            .:::|....:||||..|.                                               
Human  1259 TSEIETNIVAVERITEYT----------------------------------------------- 1276

  Fly  1859 YPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPP 1923
                                                                             
Human  1277 ----------------------------------------------------------------- 1276

  Fly  1924 ATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVS 1988
                 |||   .:...:.||:.||                           .||.:|.|.|:|..
Human  1277 -----KVE---NEAPWVTDKRPPP---------------------------DWPSKGKIQFNNYQ 1306

  Fly  1989 LRYEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPD 2053
            :||..:...|:..:|..|.:.::||:.||||:|||||...||.:|:...|.|.||.|||..|...
Human  1307 VRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLH 1371

  Fly  2054 ELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGL 2118
            :||.:|:|||||..||:.::|.||||...:.|.::|..||||.||.|| ..|.|||...:.:.|.
Human  1372 DLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFV-ASLQLGLSHEVTEAGG 1435

  Fly  2119 NLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILD 2183
            |||.|.||||||.||:||.|..|||||||:.:|..|::.:.......|...|:|||||||.||:|
Human  1436 NLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMD 1500

  Fly  2184 YDRLIVLDQGRIVEDGNPRELQQLEGSVFRGLLEKG 2219
            .|:::|||.|:|:|.|:|.||.|:.|..:....|.|
Human  1501 SDKVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAG 1536

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SurNP_001334732.1 None
ABCC2NP_000383.2 SunT 8..1537 CDD:331423 507/2246 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 253..284 0/30 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24223
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.110

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