Protein Alignment Sur and ABCB8

DIOPT Version :9

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_001269220.1
• Gene: ABCB8 / 11194
• HGNCID: 49
• Length: 735
• Species: Homo sapiens
• Alignment Length: 771
• Identity: 157/771 - (20%)
• Similarity: 277/771 - (35%)
• Gaps: 224/771 - (29%)

  Fly  1470 LPIITIFFITALIWQCLRVYTDIWLQQWSNVHGRVASKGHVVLHPSEQDHEVTYYFRMYAAISCV 1534
            |.::.:..:.||....:.|...:.|.|...|..:. ::.||....:|..:..|:...:|.....:
Human   145 LLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKY-TRDHVGSFMTESQNLSTHLLILYGVQGLL 208

  Fly  1535 CIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVID---KKI 1596
            .....::.:..|:....:.||    .|..::|.:.:.||.....|::|:|.:.|:....   |.:
Human   209 TFGYLVLLSHVGERMAVDMRR----ALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLV 269

  Fly  1597 AATGQRLLQFTLLCL-SAILINVTITPWILVLTLPICGAYYLIQKFYRCSARELQ-RIENATNSP 1659
            .:.|.|.......|| |..:::..:|..::|.|..:.|...|:....|..:|:.| :|..|
Human   270 ISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARA---- 330

  Fly  1660 VISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVAT 1724
             :....|.:..|.|:|||..:.|..|.....|||
Human   331 -MGVADEALGNVRTVRAFAMEQREEERYGAELEA------------------------------- 363

  Fly  1725 VTALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNW 1789
                      ||...|     ......:.|:               .|..:|.|..:|..::
Human   364 ----------CRCRAE-----ELGRGIALFQ---------------GLSNIAFNCMVLGTLF--- 395

  Fly  1790 VVKLLADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDA 1854
                                                                             
Human   396 ----------------------------------------------------------------- 395

  Fly  1855 GDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNF 1919
                                   |||:                       |.||.....|:.::|
Human   396 -----------------------IGGS-----------------------LVAGQQLTGGDLMSF 414

  Fly  1920 HHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQS----VPISW---- 1976
                ..|...|:::....||:..            :||.......::..|.:    :|:|.
Human   415 ----LVASQTVQRSMANLSVLFG------------QVVRGLSAGARVFEYMALNPCIPLSGGCCV 463

  Fly  1977 PQ---RGDIHFDNVSLRYEGQKQ-NVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTR 2037
            |:   ||.:.|.||...|..:.. .|:.:.||.:|.|:.:.:.|::|.||:::...|......|.
Human   464 PKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTA 528

  Fly  2038 GHIYIDDVDIQRIRPDELRTR-LSIIPQDVHLFNATIRENLDPHGYFQ--DLQLWNCLELAQLKE 2099
            |.:.:|..|::.:.|..||.: :..|.|:..||..||.||: ..|..:  |.:::.....|...|
Human   529 GVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENI-RFGKLEASDEEVYTAAREANAHE 592

  Fly  2100 FVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADL 2164
            |:.. .|.|.:||:.:.|..||.|.:|.|.:|||:::....|:||||||.||:.:|..:.:|.|.
Human   593 FITS-FPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDR 656

  Fly  2165 AFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEGSVFRGLLEKGA 2220
            |..|||::.|||||:|:.....::|:..||:.|.|...||.: :|.::..|:.:.|
Human   657 ASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLK-KGGLYAELIRRQA 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
ABCB8	NP_001269220.1	MdlB	165..713	CDD:224055	153/751 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	712..735		157/771 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910