Protein Alignment Sur and CFTR

DIOPT Version :9

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_000483.3
• Gene: CFTR / 1080
• HGNCID: 1884
• Length: 1480
• Species: Homo sapiens
• Alignment Length: 2077
• Identity: 432/2077 - (20%)
• Similarity: 744/2077 - (35%)
• Gaps: 736/2077 - (35%)

  Fly   226 ATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSA-------RSHYDHFLYIYTEKKKKSNS 283
            |:..||..|.|..|:|..||::.|||.|:.|:...|||       ...:|..|    ..||....
Human     9 ASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDREL----ASKKNPKL 69

  Fly   284 SPSLWYCYIKNSWQMFALGGILKLAGDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVAN 348
            ..:|..|:.   |: |...||....|::...:.||.:.:|:         ||..|.......:|
Human    70 INALRRCFF---WR-FMFYGIFLYLGEVTKAVQPLLLGRII---------ASYDPDNKEERSIA- 120

  Fly   349 VLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTHILNM 413
                                     ||       |..|.|:.:||      :..|...:...|:.
Human   121 -------------------------IY-------LGIGLCLLFIV------RTLLLHPAIFGLHH 147

  Fly   414 TGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPN 478
            .|::::.::..|||:|:|.|                 :|...|:
Human   148 IGMQMRIAMFSLIYKKTLKL-----------------SSRVLDK--------------------- 174

  Fly   479 ISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPL 543
            ||  ||.:.:.::.:.....|...:.|:.|..|.::|:::.|::..|..||..| :..::::...
Human   175 IS--IGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCG-LGFLIVLALF 236

  Fly   544 QFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELK------- 601
            |..:|..|.|..:..||...|||....:.:..|:.:|...|:|...|.|:..|:.|||
Human   237 QAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAY 301

  Fly   602 --YLNKDATFWT-----LMAVLTH--IATVLI--TFVTLGVYVWLHRDQEFDLNASRLFSSLALF 655
              |.|..|.|::     .::||.:  |..:::  .|.|:...:.|.               :|:.
Human   302 VRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVLR---------------MAVT 351

  Fly   656 QQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEK 720
            :|       ||..|.....:..:..:::.||:..|                        |:|.|
Human   352 RQ-------FPWAVQTWYDSLGAINKIQDFLQKQE------------------------YKTLE- 384

  Fly   721 SNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRE 785
            .|:|......||                                   .:...|.|..:|.::.::
Human   385 YNLTTTEVVMEN-----------------------------------VTAFWEEGFGELFEKAKQ 414

  Fly   786 LLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSL------LLKMPDDIAVSINDGLF 844
            ...|.                        :..|.|    |||      ||..|  :...||
Human   415 NNNNR------------------------KTSNGD----DSLFFSNFSLLGTP--VLKDIN---- 445

  Fly   845 TWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTISYV 909
                             ..:.:|:|..|.|..|:||||||..::.|:....|.:  ..:..||:.
Human   446 -----------------FKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKI--KHSGRISFC 491

  Fly   910 SQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRI 974
            ||..|::..||:|||:||.|:...||..|::||.|:.||......|..::||.||.:|||||.||
Human   492 SQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARI 556

  Fly   975 AIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAI 1039
            ::|||:|..|::.::|.|...||....:.||:.|:.:::  :|:|.||||.::..:|:|:.::.:
Human   557 SLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLM--ANKTRILVTSKMEHLKKADKILIL 619

  Fly  1040 KDGRVEACGSYADIELMQP-----------------------------RITAEWNAIIAMAKAKN 1075
            .:|.....|::::::.:||                             |.:.|.:|.::..:.|.
Human   620 HEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGDAPVSWTETKK 684

  Fly  1076 DNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACHADAIDGSGCISVANMQSNVVEED 1140
            .:                .|...:.|.:|..|:....|      :|.....:....:|.|.:|||
Human   685 QS----------------FKQTGEFGEKRKNSILNPIN------SIRKFSIVQKTPLQMNGIEED 727

  Fly  1141 DQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRN 1205
            ....              |:|:.|.          ||   |..||:.::
Human   728 SDEP--------------LERRLSL----------VP---DSEQGEAIL---------------- 749

  Fly  1206 TNSSHRLSGLSTLTATSESSSISGDVLS----RSVLATSCSSYAESSVDGGDLATAAPEPRVQSW 1266
                .|:|.:||           |..|.    :|||     :....||:.|
Human   750 ----PRISVIST-----------GPTLQARRRQSVL-----NLMTHSVNQG-------------- 780

  Fly  1267 QPPQHVTHHQPLS-RNASSPPAMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMR 1330
               |::......| |..|..|...:...|:                           :.||:|..
Human   781 ---QNIHRKTTASTRKVSLAPQANLTELDI---------------------------YSRRLSQE 815

  Fly  1331 RSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKETTIN 1395
            ..                |.||||.                     :||..|:|.
Human   816 TG----------------LEISEEI---------------------NEEDLKECF---------- 833

  Fly  1396 CDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKISDDI 1460
            .||                                      .||:|    |:.|.        :.
Human   834 FDD--------------------------------------MESIP----AVTTW--------NT 848

  Fly  1461 YLMYIRAAGLPIITIF--FITALIWQCLRVY--------TDIWL-------QQWSNVHGRVASKG 1508
            ||.|        ||:.  .|..||| ||.::        ..:||       .:.::.|.|  :..
Human   849 YLRY--------ITVHKSLIFVLIW-CLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSR--NNS 902

  Fly  1509 HVVLHPSEQDHEVTYYFRMYAAISCVCIIMALVSTPAGQYAG-------CNARRNLHDKLLQTIL 1566
            :.|:..|...:   |.|.:|..::...:.|       |.:.|       ....:.||.|:|.::|
Human   903 YAVIITSTSSY---YVFYIYVGVADTLLAM-------GFFRGLPLVHTLITVSKILHHKMLHSVL 957

  Fly  1567 HKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVTITPWILVLTLPI 1631
            ...:........|.|:||||.|:|::|..:..|....:|..|:.:.||.:...:.|:|.|.|:|:
Human   958 QAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPV 1022

  Fly  1632 CGAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTI 1696
            ..|:.:::.::..::::|:::|:...||:.:||..:::|:.|:|||.:|..|..:..|.|..:|.
Human  1023 IVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTA 1087

  Fly  1697 AYALLNTSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTK 1761
            .:.|..::.||..:.::     ::||....|:|..|:                         :|.
Human  1088 NWFLYLSTLRWFQMRIE-----MIFVIFFIAVTFISI-------------------------LTT 1122

  Fly  1762 SPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADADA 1826
            ...|.|     ||:.:...:.:...|.|.|....|::....||.|:..:
Human  1123 GEGEGR-----VGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKF---------------- 1166

  Fly  1827 DVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYR 1891
             :|...:.:|
Human  1167 -IDMPTEGKP------------------------------------------------------- 1175

  Fly  1892 QGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKV 1956
                                                      |..|...|:.||       .|.:
Human  1176 ------------------------------------------TKSTKPYKNGQL-------SKVM 1191

  Fly  1957 VLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGSG 2021
            ::.|...:|.:       .||..|.:...:::.:|......::.|::..|..|||:|:.||||||
Human  1192 IIENSHVKKDD-------IWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSG 1249

  Fly  2022 KSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDL 2086
            ||:| ||.|..|..|.|.|.||.|....|...:.|....:|||.|.:|:.|.|:||||:..:.|.
Human  1250 KSTL-LSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQ 1313

  Fly  2087 QLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLD 2151
            ::|...:...|:..:. ..|..||.|:.|||..||.||:||:||||::|..:..|:|||.::.||
Human  1314 EIWKVADEVGLRSVIE-QFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLD 1377

  Fly  2152 SSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEGSVFR 2213
            ..|...:.:....||...|:|...||:..:|:..:.:|:::.::.:..:.::|.. |.|:||
Human  1378 PVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLN-ERSLFR 1438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
CFTR	NP_000483.3	CFTR_protein	1..1480	CDD:273530	432/2077 (21%)
		ABC_membrane	85..303	CDD:279056	61/306 (20%)
		ABCC_CFTR1	389..670	CDD:213258	87/370 (24%)
		CFTR_R	639..849	CDD:291094	60/435 (14%)
		Disordered R region. /evidence=ECO:0000269|PubMed:10792060	654..831		51/342 (15%)
		ABC_membrane	866..1147	CDD:279056	70/327 (21%)
		ABCC_CFTR2	1208..1480	CDD:213256	81/234 (35%)
		Interaction with GORASP2. /evidence=ECO:0000269|PubMed:21884936	1386..1480		13/54 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1452..1480
		PDZ-binding. /evidence=ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:16331976	1478..1480

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010