Protein Alignment Sur and abcc8

DIOPT Version :9

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: XP_031756190.1
• Gene: abcc8 / 101730668
• -ID: -
• Length: 1580
• Species: Xenopus tropicalis
• Alignment Length: 2281
• Identity: 573/2281 - (25%)
• Similarity: 888/2281 - (38%)
• Gaps: 821/2281 - (35%)

  Fly    29 CGIDR---VRRVFTFFSIFLLLF-GLMFVCSRYKKCHKTLLTF--HNGRAAISLLLLAL------ 81
            |.:|.   |..||..|..|.:|| |.....|:....|.|.|.|  ||.|..::.:||.:
 Frog    26 CFVDALNVVPHVFLLFITFPILFIGWGSQSSKVHIHHSTWLHFPGHNLRWILTFILLFVLVCEIA 90

  Fly    82 -----NSFDLAR---IFLPHQNVRNLNRLFQSSPRDLNYLVVIGSGELWNALFSTLLTLMLMLYH 138
                 :.|..:|   :::|                               |:.:.|..:..::|:
 Frog    91 EGIVSDGFSKSRHLHLYMP-------------------------------AVMAFLAAVTSIVYY 124

  Fly   139 RMVERKKATVFLYASTAVEALTFALLSNELFELVRYED----FLELQTCLVAMSAMCMVSLAMLD 199
            ..:|.......|.|......|.|.   .:..:.|::.|    ||:|:.||..:       ||:..
 Frog   125 HNIETSNFPKLLIALLVYWTLAFI---TKTIKFVKFCDNGVGFLQLRFCLTGL-------LAIFY 179

  Fly   200 GLT-------------VYKECYHD----DYLDDYGKIGYKHSMATFYSKSCFWWLTPLLWLGYKE 247
            |:.             |:.:|..:    :.|.|.| :.:........||..:||:...:...:|:
 Frog   180 GMLLAVEINVIRVRRYVFYKCPKEVKPPEDLQDLG-VRFLQPFVNLLSKGTYWWMNTFIKTAHKK 243

  Fly   248 PLELEDLGQMKLEDSARSHYDHFLYIYTEKKKKSNSSP----SLWYCYIKNSWQMFALGGILKLA 308
            |::|:.:|::.:...|.::|......:..:|.||:..|    |:|:...:...:...|..|.::.
 Frog   244 PIDLKAIGKLPIAMRAVTNYLLLNKAFHSQKSKSSPCPAGPKSIWFALCQAFGRPLILSSIFRIM 308

  Fly   309 GDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVANVLLSTSRILGTEFDEVFGTNIDKVR 373
            .|:....|||.|..||.::.|........|          :.|....|...||
 Frog   309 ADMLGFAGPLCISGIVHHLSQENKTFHPQP----------IFLGVFFISSQEF------------ 351

  Fly   374 IYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTHILNMTGIRIKTSLQGLIYRKSLLLNADGG 438
                     |||.:.:|.::..|.:.|.:..|||.::...|||.::.::|..||.|.:.|:.
 Frog   352 ---------LANAYVLAVLLFFALLLQRSFLQASYYVAIETGINLRGAIQTKIYNKIMHLST--- 404

  Fly   439 CDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISHDIGSITNHMTEDTRNIMEFFLI 503
              |:.|.|::.|                                 |.|.|.:..||..:|.||.:
 Frog   405 --SNMSMGEMSS---------------------------------GQICNLVAIDTNQLMWFFFL 434

  Fly   504 IHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKR 568
            ....||:|.:|.|.:.|||..|||||:||::. |:::.|:|:|:...:|:.......|::||||:
 Frog   435 CPNLWAMPVQIIVGVILLYYILGISALIGAVV-IIVLAPIQYFVATKLSQAQRSTLEYSNERLKK 498

  Fly   569 IHDTLVGIKVIKLNAWDEVFLKKIQEARRKELKYLNKDATFWTL---MAVLTHIATVLITFVTLG 630
            .::.|.|||::||.:|:.:|...::|.|:||:..|...|.:.::   |.....||.||||||
 Frog   499 TNEMLRGIKLLKLYSWEHIFHSSVEETRQKEMNSLKAFALYTSISIFMNAAIPIAAVLITFV--- 560

  Fly   631 VYV-WLHRDQEFDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQ 694
            |:| .|||:|   .:.:..|:||:||..|..||.:....|...:.|.||.::|..|..|.||
 Frog   561 VHVHLLHREQ---FSPAVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFFSSEEI--- 619

  Fly   695 FEGIRNMARILSKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNA 759
                                                                             
 Frog   620 ----------------------------------------------------------------- 619

  Fly   760 EESAEDISPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRR 824
            .|..|...||       ||.|.|.:       |.|: |.|:..  .:||:.         |.|..
 Frog   620 GEEVEKCPPS-------NKSVPQNK-------YQAV-PLKVVN--RKRPIR---------DDWNH 658

  Fly   825 -DSLLLKMP-----DDIAVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSL 883
             :|.....|     ::..:.:..|.|||.|.....:..:   .|.:|:|:||::||:.|.||:||
 Frog   659 FNSRQRGAPNPTEGNEFCIKVTSGFFTWTPDGPPALSSI---DIRIPQGQLTMIVGQVGCGKSSL 720

  Fly   884 LSALLMEMPLLAGNMFWHKTC-------------------------TISYVSQQPWLLNDTIREN 923
            |.|.|.||..::|::.|:.|.                         .::|.||:|||||.|:.||
 Frog   721 LLATLGEMHKISGDVSWNSTVPDSETGEDVNPDKETAIDVETRRRGAVAYASQKPWLLNATVEEN 785

  Fly   924 ILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVVI 988
            |.|...|..::|..:::||:|:|||:::|.||.:.|||||||:||||||||::||.:|...:||.
 Frog   786 ITFESPFNKQKYKAIIDACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARVLYQQTSVVF 850

  Fly   989 MDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYADI 1053
            :|||.::||..:.:|:....|.:||:.:.||.:|||.:|..:..|:::||:|||.::..|:..||
 Frog   851 LDDPFSALDIHLSDHLMHEGILKMLRDNKRTTVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDI 915

  Fly  1054 ELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACHA 1118
            :...|.:.                           |.||.|.|.....|::.|
 Frog   916 QKSDPELY---------------------------EHWKTLMNRQDQELEKEI------------ 941

  Fly  1119 DAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGG--FNLQRKRSSIYGSRHLMYDVPLPID 1181
                                          |.:...||  .||.|   :||           |.|
 Frog   942 ------------------------------ILDRKAGGERMNLTR---TIY-----------PRD 962

  Fly  1182 ECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAE 1246
            ...|||
 Frog   963 ALLGDD----------------------------------------------------------- 968

  Fly  1247 SSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESP 1311
                                                             ::.||
 Frog   969 -------------------------------------------------EEDEE----------- 973

  Fly  1312 LDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQ 1376
                                                  .|||
 Frog   974 --------------------------------------EISE----------------------- 977

  Fly  1377 SEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMP 1441
            |||.                |||..|                        ||.:      |..||
 Frog   978 SEED----------------DDNLSS------------------------VLHQ------RAKMP 996

  Fly  1442 LARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFITALIWQCLRVYTDIWLQQW--------- 1497
            .        |..||        |:.:||:.::.:..::.|:...:.|..|.||.:|
 Frog   997 W--------RACGK--------YLSSAGILLLPLLVLSQLLKHSVMVAIDFWLAKWTSAAITNLS 1045

  Fly  1498 -SNVHGRVASKGHVVLHPSEQDHEVTYYFRMYAAISCVCIIMALVSTPAGQYAGCNARRNLHDKL 1561
             :|..||...:         .||  :.|...::.:|||.|||.|.::.|.::.|....:.||..|
 Frog  1046 VANCSGRPTCR---------FDH--SPYSMAFSILSCVGIIMCLATSIAVEWTGLRVAKKLHSSL 1099

  Fly  1562 LQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVTITPWILV 1626
            |..|:...:.||:.||||.|:||||.|...||:.|.||.:.|.:.||||:||:.:...:||..|:
 Frog  1100 LNAIILAPMRFFETTPLGSILNRFSADFNTIDQHIPATLECLSRSTLLCVSALAVISYVTPVFLI 1164

  Fly  1627 LTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRL 1691
            ..:|:....|.|||::|.::|:||::|::|..|::||.:||::|:||||||..:.||.:.|.:..
 Frog  1165 SLVPLAIICYFIQKYFRVASRDLQQLEDSTQLPLLSHFAETVEGLTTIRAFRYEPRFRQKLLEHT 1229

  Fly  1692 EANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASASPSPFET 1756
            ::|.||...|..::|||.|.::|:|.|:|.:|.|     ||::...||..
 Frog  1230 DSNNIASLFLTAANRWLEVRMEYIGACVVLIAAV-----ASITNSLHYNL--------------- 1274

  Fly  1757 YAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADAD 1821
                        |..||||.:.|.|:|..||||:|:.|:|||:..|:|:||
 Frog  1275 ------------SSGLVGLGLTYALMVSNYLNWMVRNLSDMEIQLGAVKRI-------------- 1313

  Fly  1822 ADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGG 1886
                   :..|..||.:                    |.|
 Frog  1314 -------NGLLKTEPEN--------------------YKG------------------------- 1326

  Fly  1887 DCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDD 1951
                                                                ::...|:||
 Frog  1327 ----------------------------------------------------LLSPTQIPP---- 1335

  Fly  1952 KDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICG 2016
                                   :||:.|:|...|:|:||:...:.|:.::...|..||:|||||
 Frog  1336 -----------------------NWPENGEIQIQNLSVRYDSSLKPVLKHVNAHITPGQKIGICG 1377

  Fly  2017 RTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHG 2081
            ||||||||..|:.|.::.|.:|.|.||.:||.::....||:|||||.||..||:.|||.||||..
 Frog  1378 RTGSGKSSFSLAFFRMVDTFQGRIIIDGIDIAKLPLQTLRSRLSIILQDPILFSGTIRFNLDPEN 1442

  Fly  2082 YFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEA 2146
            ...|..||..||:||||..|. .||.|||.::.:||.|.|.|.|||.|||||.:|.|..|::|||
 Frog  1443 KCTDAMLWEALEIAQLKHVVK-VLPGGLDALVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEA 1506

  Fly  2147 TSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEGSV 2211
            |:.:|.:||:.|.|....||..||::|||||:.|||:.|.:||:.:|.|:|...|..|.:..||:
 Frog  1507 TASIDMATENILQKVVMTAFDDRTVVTIAHRVHTILNADLVIVMKRGAIMEYDKPEALLEGGGSM 1571

  Fly  2212 FRGLLE 2217
            |...::
 Frog  1572 FASYVQ 1577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
abcc8	XP_031756190.1	MRP_assoc_pro	224..1573	CDD:188098	526/2035 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	182	1.000	Domainoid score	I3397
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	798	1.000	Inparanoid score	I492
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.060