Protein Alignment Sur and ABCC9

DIOPT Version :9

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_001364202.1
• Gene: ABCC9 / 10060
• HGNCID: 60
• Length: 1549
• Species: Homo sapiens
• Alignment Length: 2248
• Identity: 565/2248 - (25%)
• Similarity: 868/2248 - (38%)
• Gaps: 774/2248 - (34%)

  Fly    19 SIYDNLNTDICGIDR---VRRVFTFFSIFLLLF-GLMFVCSRYKKCHKTLLTF--HNGRAAISLL 77
            :|.|.:..:.|.:|.   |..||..|..|.:|| |.....|:.:..|.|.|.|  ||.|..::..
Human    14 NINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHHNTWLHFPGHNLRWILTFA 78

  Fly    78 LLALNSFDLARIFLPHQNVRNLNRLFQSSPRDLNYLVVIGSGELWNALFSTLLTLMLMLYHRMVE 142
            ||.::..::|            ..:...|.|:..:|.:     ...|:...:.|...::|:..:|
Human    79 LLFVHVCEIA------------EGIVSDSRRESRHLHL-----FMPAVMGFVATTTSIVYYHNIE 126

  Fly   143 RKKATVFLYASTAVEALTFALLSNELFELVRY----EDFLELQTCLVAMSAMCMVSLAMLDGLTV 203
            .......|.|......:.|.   .:..:||:|    .|...|:.|:..|       :.:|:||.:
Human   127 TSNFPKLLLALFLYWVMAFI---TKTIKLVKYCQSGLDISNLRFCITGM-------MVILNGLLM 181

  Fly   204 YKE-----------------CYHDDYLDDYGKIGYKHSMATFYSKSCFWWLTPLLWLGYKEPLEL 251
            ..|                 ....:.|.|.| :.:........||:.:||:..|:...:|:|::|
Human   182 AVEINVIRVRRYVFFMNPQKVKPPEDLQDLG-VRFLQPFVNLLSKATYWWMNTLIISAHKKPIDL 245

  Fly   252 EDLGQMKLEDSARSHYDHFLYIYTEKKKK----SNSSPSLWYCYIKNSWQMFALGGILKLAGDLF 312
            :.:|::.:...|.::|......|.|:|||    .|.:||:|....:...:...|....:...||.
Human   246 KAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLL 310

  Fly   313 ALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVANVLLSTSRILGTEFDEVFGTNIDKVRIYSS 377
            ...|||.|..||:.:                ||..|...:|:.|                   |.
Human   311 GFAGPLCISGIVQRV----------------NETQNGTNNTTGI-------------------SE 340

  Fly   378 TWS--DLLANGWCIAWIVLLAAITQGALSQASTHILNMTGIRIKTSLQGLIYRKSLLLNADGGCD 440
            |.|  :.|.|.:.:|.::.||.|.|....|||.::...|||.::.:|..:||.|.|.|:.
Human   341 TLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLST----- 400

  Fly   441 SSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISHDIGSITNHMTEDTRNIMEFFLIIH 505
            |:.|.|::                                 .:|.|.|.:..:|..:|.|..:..
Human   401 SNLSMGEM---------------------------------TLGQINNLVAIETNQLMWFLFLCP 432

  Fly   506 YAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKRIH 570
            ..||:|.:|.:.:.|||..||.||::|: |.||::.|:|:||...:::..:....|:.||||:.:
Human   433 NLWAMPVQIIMGVILLYNLLGSSALVGA-AVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTN 496

  Fly   571 DTLVGIKVIKLNAWDEVFLKKIQEARRKELKYLNKDATFWTL---MAVLTHIATVLITFVTLGVY 632
            :.|.|||::||.||:.:|.|.::|.|.|||..|...|.:.:|   |.....||.||.||||   :
Human   497 EILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVT---H 558

  Fly   633 VWLHRDQEFDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEG 697
            .:...:   :|..:..|:||:||..|..||.:....|...:.|.:|.::|..||.|.||..
Human   559 AYASGN---NLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGD---- 616

  Fly   698 IRNMARILSKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEES 762
                           |.:.|.| |::...:.:....:..|.:.:|              |.....
Human   617 ---------------DSWRTGE-SSLPFESCKKHTGVQPKTINRK--------------QPGRYH 651

  Fly   763 AEDISPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSL 827
            .:....||             |.|                    ||.|
Human   652 LDSYEQST-------------RRL--------------------RPAE----------------- 666

  Fly   828 LLKMPDDIAVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMP 892
                .:|||:.:.:|.|:|    ...:..|....|.:|.|:||::||:.|.||:|||.|:|.||.
Human   667 ----TEDIAIKVTNGYFSW----GSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQ 723

  Fly   893 LLAGNMFW---------------HKTCTISYVSQQPWLLNDTIRENILFGESFRPKRYDFVLEAC 942
            .|.|.:.|               ....:::|.:|:|||||.|:.|||.||..|..:||..|.:||
Human   724 TLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDAC 788

  Fly   943 ALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQH 1007
            :|:|||:|:|.||.:.|||||||:||||||||.:|||:|.:.|:|.:|||.::||..:.:|:.|.
Human   789 SLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQE 853

  Fly  1008 CIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAK 1072
            .|.:.||...||.:|||.:|..:..|:::||:|||.|...|:..||:.....:.
Human   854 GILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELY----------- 907

  Fly  1073 AKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACHADAIDGSGCISVANMQSNVV 1137
                            |.||.|.|.....|::.:
Human   908 ----------------EHWKTLMNRQDQELEKDM------------------------------- 925

  Fly  1138 EEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRG 1202
             |.||.:              |:||.     .|..||
Human   926 -EADQTT--------------LERKT-----LRRAMY---------------------------- 942

  Fly  1203 SRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQ 1267
                                                                             
Human   943 ----------------------------------------------------------------- 942

  Fly  1268 PPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRS 1332
                                          |.||:       :.::|
Human   943 ------------------------------SREAK-------AQMED------------------ 952

  Fly  1333 NKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKETTINCD 1397
                                                   ::|.:.||:.:              |
Human   953 ---------------------------------------EDEEEEEEEDE--------------D 964

  Fly  1398 DNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKISDDIYL 1462
            ||..:.    :|.                          |..||....                .
Human   965 DNMSTV----MRL--------------------------RTKMPWKTC----------------W 983

  Fly  1463 MYIRAAGLPIITIFFITALIWQCLRVYTDIWLQQWSNVHGRVASKGHVVLHPSEQDHEVTYYFRM 1527
            .|:.:.|..::.:...:.|:...:.|..|.||..|::.:. :.:.|..         :.|||
Human   984 RYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYS-INNTGKA---------DQTYY--- 1035

  Fly  1528 YAAISCVC---IIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDM 1589
            .|..|.:|   |.:.||::...::.|..|.:|||..||..|:...:.||..||||.|:||||.|.
Human  1036 VAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADT 1100

  Fly  1590 AVIDKKIAATGQRLLQFTLLCLSAILINVTITPWILVLTLPICGAYYLIQKFYRCSARELQRIEN 1654
            .:||:.|..|.:.|.:.||||||||.:....||..||..||:..|:|.|||::|.::::||.:::
Human  1101 NIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDD 1165

  Fly  1655 ATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCI 1719
            :|..|::.|.|||.:|:||||||..:|||.:.:.:..:.|.|||..|:.::|||.|..||||.||
Human  1166 STQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACI 1230

  Fly  1720 VFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVP 1784
            |..|::.:::.:|.|                                    .||||.:.|.|.:.
Human  1231 VLTASIASISGSSNS------------------------------------GLVGLGLLYALTIT 1259

  Fly  1785 IYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRS 1849
            .||||||:.|||:|:..|:|:::                               |..::.|.:.
Human  1260 NYLNWVVRNLADLEVQMGAVKKV-------------------------------NSFLTMESEN- 1292

  Fly  1850 SQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDG 1914
                     |.|.
Human  1293 ---------YEGT---------------------------------------------------- 1296

  Fly  1915 NHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQR 1979
                                          :.|.|                      ||..|||.
Human  1297 ------------------------------MDPSQ----------------------VPEHWPQE 1309

  Fly  1980 GDIHFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDD 2044
            |:|...::.:|||...:.|:.::...|..||::|||||||||||||.|:.|.::....|.|.||.
Human  1310 GEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDG 1374

  Fly  2045 VDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGL 2109
            :||.::....||:|||||.||..||:.:||.||||.....|.:||..||:||||..|.. ||.||
Human  1375 IDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKS-LPGGL 1438

  Fly  2110 DTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITI 2174
            |.|:.:||.|.|.|.|||.|||||.:|.|..|::||||:.:|.:||:.|.|....||..||::||
Human  1439 DAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTI 1503

  Fly  2175 AHRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEGSVF 2212
            |||:.|||..|.:||:.:|.|:|...|..|...|..||
Human  1504 AHRVHTILTADLVIVMKRGNILEYDTPESLLAQENGVF 1541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
ABCC9	NP_001364202.1	MRP_assoc_pro	222..1546	CDD:188098	518/2012 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	944..967		8/100 (8%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	174	1.000	Domainoid score	I3683
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H56521
Inparanoid	1	1.050	770	1.000	Inparanoid score	I538
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.060