Protein Alignment Sur and ABCC5

DIOPT Version :9

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_005679.2
• Gene: ABCC5 / 10057
• HGNCID: 56
• Length: 1437
• Species: Homo sapiens
• Alignment Length: 2098
• Identity: 463/2098 - (22%)
• Similarity: 764/2098 - (36%)
• Gaps: 762/2098 - (36%)

  Fly   178 LELQTCL--------VAMSAMCMVSLAMLD----------GLTVYK----ECYHDDYLDDYGKIG 220
            ||.|..|        :::.|.....|.:||          ||:..|    ...|...:|:.|
Human    44 LECQDALETAARAEGLSLDASMHSQLRILDEEHPKGKYHHGLSALKPIRTTSKHQHPVDNAG--- 105

  Fly   221 YKHSMATFYSKSCFWWLTPLLWLGYKE-PLELEDLGQMKLEDSARSHYDHFLYIYTEKKKKSNSS 284
                   .:|...|.||:.|..:.:|: .|.:||:..:...:|:..:......::.|:..:....
Human   106 -------LFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNEVGPD 163

  Fly   285 PS-----LW-YCYIKNSWQMFALGGILKLAGDLFALIGP-LAIQKIVEYIEQLYAQASEPPAKSP 342
            .:     :| :|..:....:..| .|.:|||    ..|| ..::.::|     |.||:|
Human   164 AASLRRVVWIFCRTRLILSIVCL-MITQLAG----FSGPAFMVKHLLE-----YTQATE------ 212

  Fly   343 GNEVANVLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQAS 407
                :|:..|...:||....|:       ||    :||  ||..|.:.:
Human   213 ----SNLQYSLLLVLGLLLTEI-------VR----SWS--LALTWALNY---------------- 244

  Fly   408 THILNMTGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVD 472
                 .||:|::.::..:.::|.|.|                     .:.|:|:
Human   245 -----RTGVRLRGAILTMAFKKILKL---------------------KNIKEKS----------- 272

  Fly   473 NPSEPNISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLY--MNLGISAVIGSIA 535
                      :|.:.|..:.|.:.:.|...:.......|  :..::.::|  :.||.:..:|| |
Human   273 ----------LGELINICSNDGQRMFEAAAVGSLLAGGP--VVAILGMIYNVIILGPTGFLGS-A 324

  Fly   536 CIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKEL 600
            ..::..|...|.....:.........||||::::::.|..||.||:.||.:.|.:.:|:.|.:|.
Human   325 VFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEER 389

  Fly   601 KYLNKDATFWTLMAVLTHIATVLITFVTLGVYVWLHRDQEFDLNASRLFSSLALFQQLTVPLLIF 665
            :.|.|...|.::...:..|..|:.:.||..|::.|    .|||.|::.|:.:.:|..:|..|.:.
Human   390 RILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTL----GFDLTAAQAFTVVTVFNSMTFALKVT 450

  Fly   666 PITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNM-----ARILSKS-----DASLDMYETQEK 720
            |.:|..:..|.|:   ::|| ||..:.::...|:|.     .:|..|:     |:|....:...|
Human   451 PFSVKSLSEASVA---VDRF-KSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPK 511

  Fly   721 SNMTMRTAQAENRLNEKRLAQKSQTPE---LATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQ 782
            ....|:..:..:|..::::.|..:|..   ||.....||.:::|     .||..:|.|
Human   512 LTPKMKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSDE-----RPSPEEEEG------- 564

  Fly   783 RRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQ 847
                                    :.:....:|.:.|
Human   565 ------------------------KHIHLGHLRLQRT---------------------------- 577

  Fly   848 PQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTISYVSQQ 912
                     ||...:.:.:|||..:.|..|||||||:||:|.:|.||.|::  ..:.|.:||:||
Human   578 ---------LHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSI--AISGTFAYVAQQ 631

  Fly   913 PWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIA 977
            .|:||.|:|:|||||:.:..:||:.||.:|.|:||:.::|..||:.|||||.|:||||||||::|
Human   632 AWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLA 696

  Fly   978 RAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDG 1042
            ||:||..::.|:||||::||..||.|||...||:.|:  ::|.:.||.||..:.:.:.:|.:|:|
Human   697 RALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLK--SKTVLFVTHQLQYLVDCDEVIFMKEG 759

  Fly  1043 RVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSIS 1107
            .:...|::.  |||
Human   760 CITERGTHE--ELM--------------------------------------------------- 771

  Fly  1108 VTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHL 1172
                                                                             
Human   772 ----------------------------------------------------------------- 771

  Fly  1173 MYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVL 1237
                                            |.|
Human   772 --------------------------------NLN------------------------------ 774

  Fly  1238 ATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEAR 1302
                          ||.||                                 :.|
Human   775 --------------GDYAT---------------------------------IFN---------- 782

  Fly  1303 RSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILA 1367
                                                       |.:|.   |:|||
Human   783 -------------------------------------------NLLLG---ETPPV--------- 792

  Fly  1368 TDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVA 1432
            ...:|.||...:|..:             |....:.|.|:.:|                    |.
Human   793 EINSKKETSGSQKKSQ-------------DKGPKTGSVKKEKA--------------------VK 824

  Fly  1433 GESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFITALIWQCLRV----YTDIW 1493
            .|.|:    |.:|   .|:..|.:...:|.:||:|||.|:.   |:..:....|.|    ::..|
Human   825 PEEGQ----LVQL---EEKGQGSVPWSVYGVYIQAAGGPLA---FLVIMALFMLNVGSTAFSTWW 879

  Fly  1494 LQQW---SNVHGRVASKGHVVLHPSEQDH-EVTYYFRMYAAISCVCIIMALVSTPAGQYAGCNAR 1554
            |..|   .:.:..|.......:..|.:|: .:.||..:||....|.:|:..:...........|.
Human   880 LSYWIKQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRAS 944

  Fly  1555 RNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVT 1619
            ..|||:|.:.||...:.||..||.|||:||||.||..:|.::....:..:|..:|....:.:...
Human   945 SRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAG 1009

  Fly  1620 ITPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFT 1684
            :.||.||...|:...:.::....|...|||:|::|.|.||.:||::.:|||:.||.|:|:...|.
Human  1010 VFPWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFL 1074

  Fly  1685 EILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASA 1749
            ....:.|:.|...:.|...:.|||.|.||     ::.:|.:|  |...:....|.:.
Human  1075 HRYQELLDDNQAPFFLFTCAMRWLAVRLD-----LISIALIT--TTGLMIVLMHGQI-------- 1124

  Fly  1750 SPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQ 1814
                               .|:..||||:|.:.:.....:.|:|.::.|....|||||.||.:..
Human  1125 -------------------PPAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTL 1170

  Fly  1815 DADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIG 1879
            ..:|.|.
Human  1171 SLEAPAR---------------------------------------------------------- 1177

  Fly  1880 GARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQ 1944
                                                                        ||:|.
Human  1178 ------------------------------------------------------------IKNKA 1182

  Fly  1945 LPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLTLKIPAG 2009
            ..|                           .|||.|::.|:|..:||......|:..::..|...
Human  1183 PSP---------------------------DWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPK 1220

  Fly  2010 QRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIR 2074
            ::|||.|||||||||||::||.:::.:.|.|.||.|.|..|...:||::||||||:..||:.|:|
Human  1221 EKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVR 1285

  Fly  2075 ENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSV 2139
            .||||...:.:.|:|:.||...:||.: ..|||.|::.:.:.|.|.|.|.|||||:|||:||...
Human  1286 SNLDPFNQYTEDQIWDALERTHMKECI-AQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCK 1349

  Fly  2140 CLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPREL 2204
            .|:|||||:.:|:.|:..:.:....||...|::||||||.|:|..||::||.||::||...|..|
Human  1350 ILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVL 1414

  Fly  2205 QQLEGSVFRGLLEKGASK 2222
            ...:.|.|..:.....:|
Human  1415 LSNDSSRFYAMFAAAENK 1432

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
ABCC5	NP_005679.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	15..41
		CFTR_protein	100..1430	CDD:273530	450/2038 (22%)
		ABC_membrane	<271..447	CDD:294371	45/203 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	501..538		6/36 (17%)
		ABCC_MRP_domain1	577..759	CDD:213217	88/222 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	794..827		9/65 (14%)
		ABC_membrane	863..1143	CDD:294371	80/313 (26%)
		ABCC_MRP_domain2	1191..1411	CDD:213211	97/220 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010