Protein Alignment Sur and abcc6

DIOPT Version :10

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: XP_002932264.3
• Gene: abcc6 / 100493037
• XenbaseID: XB-GENE-6465366
• Length: 1500
• Species: Xenopus tropicalis
• Alignment Length: 2252
• Identity: 515/2252 - (22%)
• Similarity: 814/2252 - (36%)
• Gaps: 888/2252 - (39%)

  Fly    42 SIFLLLFGLMFVCS--------RYKKCHKTLLTFHNGRAAISLLLLALNSFDLARIFLPHQNVRN 98
            ||||      |:||        |:.:.:..:......:..:..||:.:...:|      ...|.|
 Frog    41 SIFL------FICSPFYVLYLRRHGRGYIRMSALSKAKTCLGALLVLVCYTEL------FYTVWN 93

  Fly    99 LNRLFQSSPRDLNYLVVIGSGELWNALFSTLLTLMLMLYHRMV-ERKKATVFLYASTAVEALTFA 162
            :....:.:|..|...:::||        |.||...::.|.||. .|..|.:..:...|:...||.
 Frog    94 MTHNVRQAPVFLISPLILGS--------SMLLATCIIQYERMQGVRSSALLLFFWLLALLCATFQ 150

  Fly   163 L---LSNELFEL-----VRYEDFLELQTCLVAMSAMCMVSLAMLDGLTVYKECYHDD--YLDDYG 217
            |   ::..:.|.     :||..|:.....::|.|.:|               .::||  :..:..
 Frog   151 LRTKITTAISEAPQIDKLRYTLFVLYFVFVLAQSVLC---------------TFNDDPPFFSNLK 200

  Fly   218 KIG--YKHSMATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSARSHYDHFLYIYT---EK 277
            |..  ...|.::|.||..|.|.|.:::.|||:||:.||:..::..|:|    :..|.:::   ||
 Frog   201 KESNPCPVSESSFLSKVTFSWFTEIMFRGYKQPLKAEDVWSLRKSDTA----EEILTLFSKGVEK 261

  Fly   278 K-KKSN-------SSPS-----LWYCYIKNS--------------------------WQMFALGG 303
            : ||:|       .|||     :|....:.|                          ...|.|..
 Frog   262 ECKKANLLKEPTRFSPSTLDNDMWISQTEKSEIELLLKNQHIQLSQKTLLKVIMRSFGLYFLLSA 326

  Fly   304 ILKLAGDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVANVLLSTSRILGTEFDEVFGTN 368
            :|......|..|.||.::.:::.::       :|.|.|
 Frog   327 LLMTFYTAFLFISPLLVRLLLQLLK-------DPSAPS--------------------------- 357

  Fly   369 IDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTHILNMTGIRIKTSLQGLIYRKSLLL 433
                      |     .|:.:|..:.:....|........:|..:.|:|::.::.|.:|:|:|::
 Frog   358 ----------W-----QGFLVAVFLFICPCCQSLFLHQHDYICYVIGMRLRAAIVGTVYKKALMI 407

  Fly   434 NADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISHDIGSITNHMTEDTRNIM 498
            :         |||:.:|::                               |.|.|.::.|.:.:|
 Frog   408 S---------SAGRKESSA-------------------------------GEIVNLISTDVQKLM 432

  Fly   499 EFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFFIGNAMSKNAEVIAGYTD 563
            :....::|.|:.|..|.|.:|.|:..||| ||:..:|..::..|........:.:..|......|
 Frog   433 DLATCVNYMWSAPVTIIVAMYFLWQTLGI-AVLAGVAVFILNLPFMTVFAVIIKRVQEQQMKQKD 496

  Fly   564 ERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELKYLNKDATFWTLMAVLTHIATVLIT--- 625
            .|:|.|.:.|.||||:||.||:..|:||:.|.|..|||.:...|      .:|:....|.:.
 Frog   497 GRIKIISEILQGIKVLKLYAWENAFMKKVTEFRLMELKAVKTGA------LLLSGALAVFVASPF 555

  Fly   626 FVTLGVY-VWLHRDQEFDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSS 689
            :|:|.:: |:|..|::..|:|.:.|.::.|...|.:||.:||:.:.:...:.||.:|:.:|.
 Frog   556 WVSLTMFGVFLALDEKNILDAEKAFVTIILLNILRIPLRMFPMAITLFAQSSVSLKRMVKFF--- 617

  Fly   690 EIQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTP 754
                                                                             
 Frog   618 ----------------------------------------------------------------- 617

  Fly   755 LLQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNT 819
                   |||::.|.:|.
 Frog   618 -------SAEELEPESVD----------------------------------------------- 628

  Fly   820 DSWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLL 884
               ..|||     ...|::|..|.|||. .|:.|.:|....||  |:|.|..|||:.|.||||||
 Frog   629 ---INDSL-----SKHAITIRHGTFTWS-SSEPPCLQSINIGI--PQGTLVAVVGQVGCGKTSLL 682

  Fly   885 SALLMEMPLLAGNMFWHKTCTISYVSQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIE 949
            ||||.||..:.|.:  ....:::||.||.|:.|.|.:||:|||.......||.|::||||.||::
 Frog   683 SALLGEMEKVEGQV--SLMSSVAYVPQQTWIPNATFKENVLFGRKMEKCWYDQVVQACALLPDLK 745

  Fly   950 LMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQ 1014
            ::..|:.:.|||:|:|:||||:|||:||||:|.:.:|.::||||:::|..||:|:|:..|.....
 Frog   746 ILSGGENTEIGEKGVNLSGGQKQRISIARAVYRNCDVYLLDDPLSAVDAHVGQHLFEQVIGPSGL 810

  Fly  1015 KSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPS 1079
            ..::|.:|||..:..:.:.:.:|.:.||||...|:|.  ||:|
 Frog   811 LKDKTRVLVTHGVSFLPQMDMIIVMSDGRVSEVGTYN--ELLQ---------------------- 851

  Fly  1080 QNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVS 1144
                           ||
 Frog   852 ---------------KN------------------------------------------------ 853

  Fly  1145 VSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSS 1209
                      |.|           |..|
 Frog   854 ----------GAF-----------SEFL------------------------------------- 860

  Fly  1210 HRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTH 1274
                                            ::||..||
 Frog   861 --------------------------------NTYARKSV------------------------- 868

  Fly  1275 HQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHH 1339
                                  ..||:....|.:                   |::.:.|.|..|
 Frog   869 ----------------------VFEESYEEQTPN-------------------SIQGAMKMKGKH 892

  Fly  1340 HPLSATNSILSISEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSAS 1404
               ||.|.                    ||   |||                     ||
 Frog   893 ---SARND--------------------TD---NET---------------------DD------ 904

  Fly  1405 DKELRANVTSSPADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAG 1469
                                  |..|:..::|:  :..|.:|:.     |::...:||.|.:..|
 Frog   905 ----------------------VANEIEADAGK--LTEADVALT-----GRVKLSVYLEYCKIMG 940

  Fly  1470 ---LPIITIFFITALIWQCLRVYTDIWLQQWSN---VHGRVASKGHVVLHPSEQDHEVTYYF--- 1525
               |.|..:|||   :.|...:..:.|:..|::   |:|   ::.|..|...      .|.|
 Frog   941 KWYLLISALFFI---VQQAASLSYNYWIGLWADDPPVNG---TQQHTSLRLG------VYSFLGV 993

  Fly  1526 ----RMYAAISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFS 1586
                .::||.|.:.:            .|.:..|.||.:||.:||...|.||:.||.|.:.|||:
 Frog   994 MQALSIFAASSTIIV------------GGVSVSRQLHSRLLYSILRCPLSFFERTPSGNLTNRFA 1046

  Fly  1587 NDMAVIDKKIAATGQRLLQF--TLLCLSAILINVTI-TPWILVLTLPICGAYYLIQKFYRCSARE 1648
            .:|.:||..:.   |.|:.|  .:|.::.||:.::| ||...|..:|:...|:.:|:||..|:|:
 Frog  1047 KEMDIIDNTVP---QVLMLFIIMMLTIAEILLVISIATPLAAVAFIPLGLLYFFLQRFYVASSRQ 1108

  Fly  1649 LQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWLGVSLD 1713
            |:|::..:.||:.:|.:|::|||..||||.:|.||.:....||..|...|.....::|||.|..|
 Frog  1109 LKRLDAVSKSPLYTHFNESLQGVYVIRAFREQERFIQDNNMRLNMNQRFYFCSFVANRWLSVRCD 1173

  Fly  1714 YLGGCIVF-VATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAI 1777
            :|...||| ||.|..|...::                                   :|.|||||:
 Frog  1174 FLSNFIVFTVAIVGVLFRDNI-----------------------------------TPGLVGLAV 1203

  Fly  1778 NYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDV 1842
            ..:|.:...|...|.:..|||..:.||||:..|     .||:.:|...:|..:||.
 Frog  1204 VNSLRLTGVLKEAVHVATDMETNSVSVERVKEY-----CDAEPEAPWTSDNASDLS--------- 1254

  Fly  1843 SAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNA 1907
                                                                             
 Frog  1255 ----------------------------------------------------------------- 1254

  Fly  1908 GNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSV 1972
                                                                             
 Frog  1255 ----------------------------------------------------------------- 1254

  Fly  1973 PISWPQRGDIHFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTR 2037
              :||.:|.|.|.|..|||.......:.|:|..|..|:::||.||||:|||||.|.||.:|:...
 Frog  1255 --NWPSKGKIEFQNYGLRYRPDLDLALKNVTASIQQGEKVGIVGRTGAGKSSLTLGLFRILEPAT 1317

  Fly  2038 GHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVN 2102
            |.|.||:.||..:...|||::::|||||..||:.|:|.||||...:.|..:|..|:||.||.|.:
 Frog  1318 GRICIDEKDISELGLHELRSKITIIPQDPVLFSGTLRMNLDPFDNYSDNDIWVALQLAHLKVFAS 1382

  Fly  2103 GHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFR 2167
            | ||.||..:..:||.|||.|.|||:|||||:||.:..|||||||:.:|..|:..:.......|.
 Frog  1383 G-LPEGLSYICTEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQNTIRKEFE 1446

  Fly  2168 GRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEG 2209
            ..|||||||||.||:||.|::|.|:|.|||...|..|.:.:|
 Frog  1447 DCTIITIAHRLNTIMDYTRVVVFDKGEIVEFDTPATLLENKG 1488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	ABC_6TM_SUR1_D1_like	301..682	CDD:350035	84/384 (22%)
		TM helix 1	301..324	CDD:350035	6/22 (27%)
		TM helix 2	385..433	CDD:350035	10/47 (21%)
		TM helix 3	480..525	CDD:350035	12/44 (27%)
		TM helix 4	526..575	CDD:350035	12/48 (25%)
		TM helix 5	587..631	CDD:350035	13/46 (28%)
		TM helix 6	648..681	CDD:350035	9/32 (28%)
		ABCC_MRP_domain1	837..1043	CDD:213217	86/205 (42%)
		ABC_6TM_SUR1_D2_like	1475..1811	CDD:350046	101/349 (29%)
		TM helix 1	1475..1496	CDD:350046	5/20 (25%)
		TM helix 2	1520..1568	CDD:350046	13/54 (24%)
		TM helix 3	1575..1620	CDD:350046	15/46 (33%)
		TM helix 4	1621..1670	CDD:350046	16/48 (33%)
		TM helix 5	1682..1727	CDD:350046	18/45 (40%)
		TM helix 6	1777..1810	CDD:350046	10/32 (31%)
		ABCC_MRP_domain2	1980..2201	CDD:213211	107/220 (49%)
abcc6	XP_002932264.3	MRP_assoc_pro	5..1499	CDD:188098	515/2252 (23%)