Protein Alignment Sur and cftr

DIOPT Version :9

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: XP_031754831.1
• Gene: cftr / 100486085
• XenbaseID: XB-GENE-853972
• Length: 1485
• Species: Xenopus tropicalis
• Alignment Length: 2027
• Identity: 435/2027 - (21%)
• Similarity: 752/2027 - (37%)
• Gaps: 633/2027 - (31%)

  Fly   226 ATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSARSHYDHFLYIYTEKKKKSNSSP----S 286
            |:.:|:..|.|..|:||.||::.|||.|:.|:...|||.:..:.....:..:...|..:|    :
 Frog     9 ASIFSQIFFSWTKPILWKGYRQRLELSDIYQIHPGDSADNLSERLEREWDREVATSKKNPKLINA 73

  Fly   287 LWYCYIKNSWQMFALGGILKLAGDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVANVLL 351
            |..|:.   |: |...|||...|::...:.||.:.:|:
 Frog    74 LKRCFF---WK-FLFYGILLYLGEVTKAVQPLLLGRII--------------------------- 107

  Fly   352 STSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTHILNMTGI 416
                           .:.|:...:..:.:..||.|.|:.::|.:..:......      |:..|:
 Frog   108 ---------------ASYDRDNEHERSIAYYLAIGLCLLFVVRMLLLHPAIFG------LHHIGM 151

  Fly   417 RIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISH 481
            :::.::..|||:|:|.|::    ...|.....|..|..|:...|.|:.:|
 Frog   152 QMRIAMFSLIYKKTLKLSS----RVLDKISTGQLVSLLSNNLNKFDEGLA--------------- 197

  Fly   482 DIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFF 546
                                 :.|:.|..|.::.:::.||:..|..||..| :..::|:...|.:
 Frog   198 ---------------------LAHFVWIAPLQVLLLMGLLWDLLQASAFCG-LGFLIILALFQAW 240

  Fly   547 IGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELKYLNKDATFWT 611
            :|..|.|..:..||..:|||....:.:..|:.:|...|:....|.|:..|..|||...|.|
 Frog   241 LGRMMMKYRDKRAGKINERLVITSEIIENIQSVKAYCWESAMEKIIETIRETELKLTRKAA---- 301

  Fly   612 LMAVLTHIATVLITFVTLGVYVWLHRDQEFDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAAR 676
                                ||             |.|:|.|.|  .:...::|...||.::...
 Frog   302 --------------------YV-------------RYFNSSAFF--FSGFFVVFLCIVPHLLLDG 331

  Fly   677 VSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQ 741
            :|.|::  |...|     |..:..||.......|....|:          :....|::.|  ..|
 Frog   332 ISLRKI--FTTIS-----FSIVLRMAVTRQFPWAVQTWYD----------SLGVINKIQE--FLQ 377

  Fly   742 KSQTPELATNSTPLLQNAEESAEDISPSTVQELGH--NKLVQQRRELLRNTPYVAIRPPKMRGSV 804
            |.:...|..|    |...|.:.|::|.|..:.:|.  .|..|:
 Frog   378 KEEYKSLEYN----LTTTEVAMENVSASWDEGIGEFFEKAKQE---------------------- 416

  Fly   805 MERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDG-LFTWQPQSQMPVVQLHVPGII----- 863
                                              :|.| :....|........|||..::
 Frog   417 ----------------------------------VNGGNISNEDPSPFFSNFSLHVAPVLRNINF 447

  Fly   864 -VPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTISYVSQQPWLLNDTIRENILFG 927
             :.||:|..:.|..|:||||||..::.|:...||.:  ..:..||:..|..|::..||:|||:||
 Frog   448 KIEKGQLLAIAGSTGAGKTSLLMMIMGELEPSAGKI--KHSGRISFSPQVSWIMPGTIKENIIFG 510

  Fly   928 ESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVVIMDDP 992
            .|:...||..|::||.|:.||...|..|.:::||.||.:|||||.||::|||:|..|::.:||.|
 Frog   511 VSYDQYRYLSVIKACQLEEDISKFPEKDNTVLGEGGITLSGGQRARISLARAVYKDADLYLMDSP 575

  Fly   993 LASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQ 1057
            .:.||....:.||:.|:.:::  :|:|.||||.::.::|:|:.::.:.:|.....|::::::..:
 Frog   576 FSYLDLFTEKEIFESCVCKLM--ANKTRILVTSKVEQLKKADKVLILHEGSCYFYGTFSELQDQR 638

  Fly  1058 PRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACHADAID 1122
            |..::.                              |........:|..|:..:....|..|:
 Frog   639 PEFSSH------------------------------LTGFDHFNAERRNSIITETLRRCSIDS-- 671

  Fly  1123 GSGCISVANMQSNVVEEDDQVSVSYPIGNAS---CGGFNLQRKRSSIYGSRHLMYDVPLPIDECQ 1184
                              |..:|...:.|.|   ...|:.:||.|
 Frog   672 ------------------DPTAVRNEVKNKSFKQVADFSEKRKNS-------------------- 698

  Fly  1185 GDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAESSV 1249
                ::.||:.   .|:.|....|..::||:       |...|..:...|.:.....|...|:|:
 Frog   699 ----VINPRKS---SRKFSIMQKSQPQMSGI-------EEEDIPPNQGERKLSLVPESEQGEASL 749

  Fly  1250 DGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPLDD 1314
            ...::....|..:.:..|...::.....:|:.::   |....|..|:|......||:|.|..:
 Frog   750 PRSNVLNTGPTFQGRRRQSVLNLMTRTSVSQGSN---AFATRNTSVRKMSVGSFSNSSFEVDI-- 809

  Fly  1315 HVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQSEE 1379
                    :.||:|.                :|||.:|||.                     :||
 Frog   810 --------YNRRLSQ----------------DSILEVSEEI---------------------NEE 829

  Fly  1380 KPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMPLAR 1444
            ..|:|.          .||              |.||:.....|
 Frog   830 DLKECF----------LDD--------------TDSPSPTTTWN--------------------- 849

  Fly  1445 LAIDTERKYGKISDDIYLMYIRA-AGLPIITIFFITALIWQCLRVYTDIWL--------QQWSNV 1500
                           .|:.::.| .....|.:|.|...:.:.:.....:|:        ...||.
 Frog   850 ---------------TYIRFLTAHKNFIFILVFCIVIFLAEVIASSAGLWIIKRNAPVSNMTSNE 899

  Fly  1501 HGRVASK--GHVVLHPSEQDHEVTYYFRMYAAISCVCIIMALVSTPAGQYAG-------CNARRN 1556
            :...||.  ..:|.|.|       :|:..|..:.....::||     |.:.|       .:..|.
 Frog   900 NISEASDILSVIVTHTS-------FYYVFYIYVGVADSLLAL-----GIFRGLPLVHSLISVSRV 952

  Fly  1557 LHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVTIT 1621
            ||.|:|.:|||..:..|.....|||:||||.|.|::|..:..:.....|..|:.:.||.:...:.
 Frog   953 LHKKMLHSILHAPMSTFNTMRAGRILNRFSKDTAILDDILPLSIFDFTQLVLIVIGAITVVSLLE 1017

  Fly  1622 PWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEI 1686
            |:|.:.|:|:..|:.|::.::..::::|:::|:...||:.:||..:::|:.|:|||.:|..|..:
 Frog  1018 PYIFLATVPVIAAFILLRSYFLHTSQQLKQLESEARSPIFAHLITSLKGLWTLRAFGRQPYFETL 1082

  Fly  1687 LFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASASP 1751
            ..|.|..:|..:.|..::.||..::::     ::||....|::..|::
 Frog  1083 FHKALNLHTANWFLYLSTLRWFQMTIE-----MIFVIFFIAVSFISIA----------------- 1125

  Fly  1752 SPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDA 1816
                    |....|.:     ||:.:...:.:...|.|.|....|::....||.||..:
 Frog  1126 --------TSGAGEEK-----VGIVLTLAMNIMNTLQWAVNASIDVDSLMRSVSRIFRF------ 1171

  Fly  1817 DADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGA 1881
                         .|:..|
 Frog  1172 -------------IDMPRE---------------------------------------------- 1177

  Fly  1882 RGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLP 1946
                                       .:..|.||                        ||.||
 Frog  1178 ---------------------------ELIHDNNH------------------------KDDQL- 1190

  Fly  1947 PQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLTLKIPAGQR 2011
                  .:.::..|:..:|.:       .||..|.:...|:|.:|:.....|:.|::..:..|||
 Frog  1191 ------SEVLIYENDYIKKNQ-------VWPSGGQMTVKNLSAKYKDGGHTVLENISFSLNPGQR 1242

  Fly  2012 IGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIREN 2076
            :|:.||||||||:| ||.|..|.:|:|.|.||.|..|.|...:.|....::||.|.:|:.|||:|
 Frog  1243 VGLLGRTGSGKSTL-LSAFLRLLSTQGDIQIDGVSWQTIPLQKWRKAFGVVPQKVFIFSGTIRKN 1306

  Fly  2077 LDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCL 2141
            |||:|.:.|.:|....|...||..:: ..|..||.|:.|||..||.||:||:||||::|..:..|
 Frog  1307 LDPYGKWSDEELLKVTEEVGLKSIID-QFPGQLDFVLLDGGCVLSHGHKQLVCLARSVLSKAKIL 1370

  Fly  2142 VLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRE--- 2203
            :|||.::.||..|...:.|....||...|:|...|||..:|:....:|      :||...|:
 Frog  1371 LLDEPSAHLDPITFQIIRKTLKHAFANCTVILSEHRLEAMLECQHFLV------IEDNTVRQYDS 1429

  Fly  2204 LQQL--EGSVFR 2213
            :|:|  |.|.|:
 Frog  1430 IQKLMNEKSFFK 1441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
cftr	XP_031754831.1	CFTR_protein	1..1472	CDD:273530	435/2027 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010