Protein Alignment Sur and abcc8b

DIOPT Version :10

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: XP_068071075.1
• Gene: abcc8b / 100329706
• ZFINID: ZDB-GENE-120215-45
• Length: 1608
• Species: Danio rerio
• Alignment Length: 2288
• Identity: 573/2288 - (25%)
• Similarity: 888/2288 - (38%)
• Gaps: 794/2288 - (34%)

  Fly    10 CDHLNGHVRSIYDNLNTDIC---GIDRVRRVFTFFSIFLLLF-GLMFVCSRYKKCHKTLLTF--H 68
            |...|.....:.:.|..:.|   .:|.|..||..||.|.:|| |.....|:....|.|.|.|  |
Zfish    22 CGSDNSSAYKVDNGLLNNGCFLDALDVVPHVFLLFSTFPILFIGWGSQSSKVHIHHSTWLHFPGH 86

  Fly    69 NGRAAISLLLLALNSFDLARIFLPHQNVRNLNRLFQSSPRDLNYLVVIGSGELWNALFSTLLTLM 133
            |.|..::.:||.|...::|. .:..........|....|..|..|..|.|
Zfish    87 NLRWLLTAILLFLLVCEIAE-GIVSDGFNQSRHLHLYMPAGLAILAAITS--------------- 135

  Fly   134 LMLYHRMVERKKATVFLYASTAVEALTFALLSNELFELVRYED----FLELQTCLVAMSAMCMVS 194
             ::|:..:|.......|.|......|.|.   .:..:.|:|:|    ..:|:.|:..:
Zfish   136 -IIYYHNIETSNFPKLLIALLIYWTLAFV---TKTIKFVKYDDHGIGLRQLRFCITGL------- 189

  Fly   195 LAMLDGLTVYKE-------------CYHD----DYLDDYGKIGYKHSMATFYSKSCFWWLTPLLW 242
            ||:|.||.:..|             |..:    |.|.|.| :.:........|||.:||:...:.
Zfish   190 LALLYGLMLGVEVNVILRRRYMWFACPTEVKPPDDLQDLG-VRFLQPFVNLLSKSTYWWMNTFIT 253

  Fly   243 LGYKEPLELEDLGQMKLEDSARSHYDHFLYIYTEKKKKSNSSPSLWYCYIKNSWQMF-----ALG 302
            ..::.|::|:.:|  ||..|.|:     |..:.:.:|..:|.......:::.|..|:     |.|
Zfish   254 SAHQRPIDLKTIG--KLPKSMRA-----LSNFQQLRKAFDSQMESGCVHLQGSGWMWRALRQAFG 311

  Fly   303 GILKLA------GDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVANVLLSTSRILGTEF 361
            ..|.|:      .||....|||.|..|:::|.: ....:.||.|               :||..|
Zfish   312 APLLLSICFRFISDLLGFAGPLCISGILQHISR-DNHTAPPPVK---------------LLGVHF 360

  Fly   362 --DEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTHILNMTGIRIKTSLQG 424
              .|||                 .||.:.:|.::.||.:.|....|||.::....||.::.::|.
Zfish   361 ISSEVF-----------------FANAYVLAVLLFLALLLQRTFLQASYYVAIENGINLRGAVQT 408

  Fly   425 LIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISHDIGSITNH 489
            .||.|.:.|     |.|:.|.|                 .|.|.:                |.|.
Zfish   409 KIYNKIMRL-----CTSNMSMG-----------------DMTTAQ----------------ICNL 435

  Fly   490 MTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFFIGNAMSKN 554
            :..||..:|.||.:....||:|.:|.:.:.|||..||.||:||: ..|.::.|||:|:...:|:.
Zfish   436 VARDTNQLMWFFFLCPNLWAMPVQIVIGVLLLYYLLGASALIGA-TVITVLAPLQYFVATRLSRA 499

  Fly   555 AEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELKYLNKDATFWTL---MAVL 616
            .:....||.||||:.::.|.|||::||.||:.:|...::|.||:||..|...|.:.:|   |...
Zfish   500 QKSTLEYTSERLKKTNELLRGIKLLKLYAWEHIFRSSVEETRRQELTSLRTFALYTSLSIFMNAA 564

  Fly   617 THIATVLITFVTLGVYVWLHRDQEFDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVSTRR 681
            ..||.||..||   |:|.|....:|.|:.:..|.||:||..|..||.:....:...:.|.||.::
Zfish   565 IPIAAVLTIFV---VHVHLQSSSDFALSPAVAFGSLSLFHILVTPLFLLSSVLHSTVKALVSVQK 626

  Fly   682 LERFLKSSEIQKQFEGIRNMARILSKSDASL-DMYETQEKSNMTMRTAQAENRLNEKRLAQKSQT 745
            |..||.|:||:...:.|   |:..:.::.:: .:|..|.::.:..|..:|:..:|
Zfish   627 LSEFLSSAEIETDQDPI---AQTPANNNGNIKSVYALQLQAKLVNRKNKAKQDVN---------- 678

  Fly   746 PELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVE 810
                       :|.|:..:::..|...|
Zfish   679 -----------RNFEQQDQELRASAQHE------------------------------------- 695

  Fly   811 FSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVVGK 875
                                  |:|.:.|.:|.|:| .|....:..:.:.   ||.|:||::||:
Zfish   696 ----------------------DNICIKIVNGYFSW-TQGCPTLTNIDIK---VPFGQLTMIVGQ 734

  Fly   876 NGSGKTSLLSALLMEMPLLAGNMFWH-----------------------KTCTISYVSQQPWLLN 917
            .||||:|||.|.|.||..::|::.|:                       :..:::|.||:|||||
Zfish   735 VGSGKSSLLLAALGEMQKISGSITWNSLPRSDSDENIRAHDMSGRQSFTRRGSVAYASQRPWLLN 799

  Fly   918 DTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGER----GINISGGQRQRIAIAR 978
            .|:.|||||..:...|||..|:|.|.|.|||:.:|:||.::||||    ||.:||||||||::||
Zfish   800 ATVEENILFDTAPNVKRYKDVIEVCQLGPDIDTLPQGDQTVIGERVRHLGIILSGGQRQRISVAR 864

  Fly   979 AIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGR 1043
            |:|...|||.:|||.::||..:.:|:....|.:.|::..|:.:|||.:|..:..|:::||::||.
Zfish   865 ALYQQTNVVFLDDPFSALDIHLSDHLMHEGILKFLRQEKRSVVLVTHKLQYLPHADWIIAMRDGT 929

  Fly  1044 VEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISV 1108
            |:..|:..||:..:|.:.                           |:|:.|.|
Zfish   930 VQTQGTLKDIQCAEPELF---------------------------EQWRTLMN------------ 955

  Fly  1109 TMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLM 1173
                                         .:|.:.|.              :.||.|.  .|.:|
Zfish   956 -----------------------------RQDKENST--------------ELKRKSF--RRAMM 975

  Fly  1174 YDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLA 1238
            |                                                          ||..:|
Zfish   976 Y----------------------------------------------------------SRDTVA 982

  Fly  1239 TSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARR 1303
            |          |..|.|.|                               :||..:||.|.
Zfish   983 T----------DDEDEAVA-------------------------------DVAVSEVKDSS---- 1002

  Fly  1304 SNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILAT 1368
                                                                             
Zfish  1003 ----------------------------------------------------------------- 1002

  Fly  1369 DGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAG 1433
                                                        ||:..|......||
Zfish  1003 --------------------------------------------TSTDEDSLGAELRH------- 1016

  Fly  1434 ESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFITALIWQCLRVYTDIWLQQWS 1498
               |.::|.:..|                .|::||||.::.:..::.|....|.|..|.||..|:
Zfish  1017 ---RTTIPWSSFA----------------TYLKAAGLFLLPLLIVSQLAKHSLMVAIDFWLAHWT 1062

  Fly  1499 NVHGRVASKGHVVLHPSEQ-------------DHEVTYYFRMYAAISCVCIIMALVSTPAGQYAG 1550
            :         .|:...||.             .|  ::|.:::..:..:.|::.||::.|.::.|
Zfish  1063 S---------DVIAAQSESAERNCTFTKDCVFSH--SWYLQVFCLLCALGIVLCLVTSLAVEWTG 1116

  Fly  1551 CNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAIL 1615
            ....:.||..||:.|:...:..|:.||||.|:||||.|...||:.|..|.:.|.:.||||:||:.
Zfish  1117 LRVAKELHCSLLRIIVLAPMRLFETTPLGNILNRFSTDTNTIDQHIPVTMECLSRSTLLCVSAVG 1181

  Fly  1616 INVTITPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQ 1680
            :...:||..|:..||:..|.|.|||::|.::|:||::|::|..|::||.|:||:|:||||||..:
Zfish  1182 VISYVTPVFLIALLPLTVACYFIQKYFRVASRDLQQLEDSTEMPLLSHYSQTIEGLTTIRAFRHE 1246

  Fly  1681 TRFTEILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRRHYEATTSP 1745
            .||.:.|.:..:||.|:...|..::|||.|.::|:|..:|.:|.|.::|.|...
Zfish  1247 QRFKKKLLEHTDANNISSLFLTAANRWLEVRMEYIGALVVLIAAVASITNALYR----------- 1300

  Fly  1746 SASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHY 1810
                                 :.|..||||.:.|.|:|..||||:|:.|||||:..|.|:|:
Zfish  1301 ---------------------QLSAGLVGLGLTYALMVSNYLNWIVRNLADMEVQLGCVKRV--- 1341

  Fly  1811 AQGQDADADADADADADVDADLDH-EPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGD 1874
                               :.|.| :|.|.:::
Zfish  1342 -------------------SGLIHTQPESYDNI-------------------------------- 1355

  Fly  1875 QQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSV 1939
                                                                             
Zfish  1356 ----------------------------------------------------------------- 1355

  Fly  1940 IKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLTL 2004
                 :.|.|                      ||..||:.|:|...|:|:||:...:.|:.:::.
Zfish  1356 -----MTPAQ----------------------VPAGWPKYGEIQIQNLSVRYDSSLKPVLKHVSA 1393

  Fly  2005 KIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLF 2069
            .|..||::||||||||||||..|:||.::.|..|.|.||.:||.::....||::.|||.||..||
Zfish  1394 HIRPGQKVGICGRTGSGKSSFSLALFRMVDTFEGQISIDGIDISKLPLQTLRSKFSIILQDPILF 1458

  Fly  2070 NATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAI 2134
            :.|||.||||.....|..||..||:|||...|.. ||.|||.|:.:||.|.|.|.|||.|||||.
Zfish  1459 SGTIRFNLDPERKATDEMLWEALEIAQLMPVVKA-LPGGLDAVVTEGGENFSQGQRQLFCLARAF 1522

  Fly  2135 LRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDG 2199
            :|.|..|::||||:.:|.:|||.|.|....||..||::|||||:.|||..|.:||:..|.|:|..
Zfish  1523 VRKSSILIMDEATASIDMATESILQKVVMTAFADRTVVTIAHRVHTILGSDVVIVMKHGGIIEYD 1587

  Fly  2200 NPRELQQLEGSVF 2212
            .|..|.:.:.|||
Zfish  1588 EPDVLLEQKDSVF 1600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	ABC_6TM_SUR1_D1_like	301..682	CDD:350035	114/391 (29%)
		TM helix 1	301..324	CDD:350035	9/28 (32%)
		TM helix 2	385..433	CDD:350035	14/47 (30%)
		TM helix 3	480..525	CDD:350035	14/44 (32%)
		TM helix 4	526..575	CDD:350035	18/48 (38%)
		TM helix 5	587..631	CDD:350035	16/46 (35%)
		TM helix 6	648..681	CDD:350035	11/32 (34%)
		ABCC_MRP_domain1	837..1043	CDD:213217	90/232 (39%)
		ABC_6TM_SUR1_D2_like	1475..1811	CDD:350046	112/348 (32%)
		TM helix 1	1475..1496	CDD:350046	6/20 (30%)
		TM helix 2	1520..1568	CDD:350046	11/47 (23%)
		TM helix 3	1575..1620	CDD:350046	21/44 (48%)
		TM helix 4	1621..1670	CDD:350046	22/48 (46%)
		TM helix 5	1682..1727	CDD:350046	16/44 (36%)
		TM helix 6	1777..1810	CDD:350046	16/32 (50%)
		ABCC_MRP_domain2	1980..2201	CDD:213211	107/220 (49%)
abcc8b	XP_068071075.1	MRP_assoc_pro	239..1601	CDD:188098	519/2043 (25%)