Protein Alignment Sur and abcc5

DIOPT Version :9

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: XP_012818083.1
• Gene: abcc5 / 100125060
• XenbaseID: XB-GENE-986260
• Length: 1437
• Species: Xenopus tropicalis
• Alignment Length: 2128
• Identity: 467/2128 - (21%)
• Similarity: 768/2128 - (36%)
• Gaps: 782/2128 - (36%)

  Fly   138 HRMVERKKATVFLY---ASTAVEALTFALLSNELFELVRYEDFLELQTCLVAMSAMCMVSLAMLD 199
            |...|||:...|.|   .|..|:.|                |.||    ..|.:....:.:::..
 Frog    24 HNQDERKEPRDFKYQKAKSQHVDCL----------------DALE----TAARAEGLPLDISVHS 68

  Fly   200 GLTVYKECYHD-------DYLDDYGKIGYKH----SMATFYSKSCFWWLTPLLWLGYKE------ 247
            .|.:..|.:|.       :.|..: :|..||    ..|..:|...|.||||:..:.||:
 Frog    69 NLKILDEGHHKGKYHKGLNLLKPF-RITSKHQHPVDNAGLFSFMTFSWLTPMARIAYKKGELFFE 132

  Fly   248 ---PL---ELEDLGQMKLEDSARSHYDHFLYIYTEKKKKSNSSPS-LW-YCYIKNSWQMFALGGI 304
               ||   |..|:...:||..       :|...|||....:|..| :| :|..:....:..| .:
 Frog   133 DIWPLSKHESSDINSKRLEKL-------WLEEVTEKGADESSLRSVVWHFCRTRLIISIMCL-ML 189

  Fly   305 LKLAGDLFALIGP-LAIQKIVEYIEQLYAQASEPPAKSPGNEVANVLLSTSRILGTEFDEVFGTN 368
            .:|||    .||| ..::.::||.:|        .:|.||..    ||....:|.||.
 Frog   190 TQLAG----FIGPAFVVKSLLEYTQQ--------SSKDPGYS----LLLVFALLMTEI------- 231

  Fly   369 IDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTHILNMTGIRIKTSLQGLIYRKSLLL 433
               ||    :||  ||..|.:.:                     .||.|::.::..:.::|.|.|
 Frog   232 ---VR----SWS--LALTWALNY---------------------RTGSRLRGAVLTMAFKKILKL 266

  Fly   434 NADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISHDIGSITNHMTEDTRNIM 498
                                 .:.|:|:                     :|.:.|..:.|.:.:.
 Frog   267 ---------------------KNIKEKS---------------------MGELINVCSSDGQRMF 289

  Fly   499 EFFLIIHYAWAIPFKIAVVIYLLY--MNLGISAVIGSIACIVIMTPLQFFIGNAMSKNAEVIAGY 561
            |...:.......|  |..::.::|  :.||.:..:|| |..::..|...|:....:.........
 Frog   290 EAAAVGSLLAGGP--IVAILGMIYNVIILGPTGFLGS-AVFILFYPAMMFVSRLTAYFRRKCVSV 351

  Fly   562 TDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELKYLNKDATFWTLMAVLTHIATVLITF 626
            ||||::::::.|..||.||:.||.:.|.:.:|:.|..|...|.:...|.::...:..|..|:.:.
 Frog   352 TDERVQKMNEVLNYIKFIKMYAWVKAFSQNVQKIRENERSILERAGYFQSITVGIAPIVVVIASV 416

  Fly   627 VTLGVYVWLHRDQEFDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEI 691
            :|..|::.|    .:||.|::.|:.:.:|..:|..|.:.|.:|..:..|.||..|.:......|:
 Frog   417 LTFSVHMIL----GYDLTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVSMDRFKSLFLMEEV 477

  Fly   692 QKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLL 756
                       .::.|..:|.::....:.:.:...|..|..:.:.|      .||:|......:.
 Frog   478 -----------HMVKKKPSSPNLIIELKNATLAWDTTYASTQCSPK------GTPKLKKGKKGVK 525

  Fly   757 QNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDS 821
            ...|:.:.:|..|..      .|.:|:..||.::.              |.|
 Frog   526 GKKEKCSHEIEGSQA------VLAEQKGHLLIDSD--------------EHP------------- 557

  Fly   822 WRRDSLLLKMPDDIAVSINDGLFTWQPQSQMPVVQ------LHVPGIIVPKGKLTIVVGKNGSGK 880
                     .||             :...::||:.      |:...:.:.||||..:.|..||||
 Frog   558 ---------SPD-------------EETKELPVINVKLQRALYSIDLDIEKGKLIGICGSVGSGK 600

  Fly   881 TSLLSALLMEMPLLAGNMFWHKTCTISYVSQQPWLLNDTIRENILFGESFRPKRYDFVLEACALK 945
            |||:||:|.:|.||.|::  ..:.:.:||:||.|:||.|:|:|||||:.|..:.|:.||..|.|:
 Frog   601 TSLISAILGQMTLLEGSI--AVSGSFAYVAQQAWILNATLRDNILFGKEFDEEEYNAVLNVCCLR 663

  Fly   946 PDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIR 1010
            ||:.::|.|||:.|||||.|:||||||||::|||:||..::.|:||||::||..||.|||...||
 Frog   664 PDLAILPNGDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIR 728

  Fly  1011 EMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKN 1075
            :.|:  ::|.:.:|.||..:.:.:.:|.:|:|.:...|::.|:    .::..|:.||..
 Frog   729 KHLK--SKTILFITHQLQYLVDCDDVIYMKEGCITERGTHEDL----IKLNGEYAAIFN------ 781

  Fly  1076 DNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACHADAIDGSGCISVANMQSNVVEED 1140
                                                                             
 Frog   782 ----------------------------------------------------------------- 781

  Fly  1141 DQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRN 1205
                 ::.:|:|
 Frog   782 -----NFQLGDA----------------------------------------------------- 788

  Fly  1206 TNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQ 1270
                                                                             
 Frog   789 ----------------------------------------------------------------- 788

  Fly  1271 HVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKP 1335
                                  |.:::....:....|.:.||:
 Frog   789 ----------------------PHIEQMNLKKNLKNSLKKPLE---------------------- 809

  Fly  1336 KNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNC 1400
                                             .|||..:..:||..|
 Frog   810 ---------------------------------KGNKAGSVKKEKTVK----------------- 824

  Fly  1401 YSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYI 1465
                                  .|...|.::. |.|:.|:|.:                :|..||
 Frog   825 ----------------------KEEGQLMQLE-EKGKGSVPWS----------------VYGAYI 850

  Fly  1466 RAAGLPIITIFFITALIWQCLRV----YTDIWLQQWSN---------VHGRVASKGHVVLHPSEQ 1517
            ::||.|...:..:|..:   |.|    :::.||..|..         ||...     ||.:..:.
 Frog   851 QSAGGPFAFLIIMTLFV---LNVGSTAFSNWWLSYWIKQGSGNTTVVVHNET-----VVSNSMKD 907

  Fly  1518 DHEVTYYFRMYAAISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIV 1582
            :..|.:|..:||....|.:::..|...........|...|||:|.:.||...:.||..||.||::
 Frog   908 NPHVLFYTAIYALSMVVMLLLKAVRGIVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRVL 972

  Fly  1583 NRFSNDMAVIDKKIAATGQRLLQFTLL---CLSAILINVTITPWILVLTLPICGAYYLIQKFYRC 1644
            ||||.||..:|.::....:..:|..:|   ||..|..   :.||.||...|:...:.::....|.
 Frog   973 NRFSKDMDEVDVRLPFQAEMFVQNVILVFFCLGVISF---VFPWFLVAVGPLVVLFTILHVVSRV 1034

  Fly  1645 SARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWLG 1709
            ..|||:|:||.|.||.:||::.:|||:|||.|:::...|.....:.|:.|...:.|.|.:.|||.
 Frog  1035 FIRELKRLENITQSPFLSHITSSIQGLTTIHAYSKGNEFLLRYQELLDNNQAPFYLFNCAMRWLA 1099

  Fly  1710 VSLDYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVG 1774
            :.||     ::.|:.:|  |...:....|...                           ||:..|
 Frog  1100 IRLD-----VISVSLIT--TTGLMIVLMHGNI---------------------------SPAYAG 1130

  Fly  1775 LAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSN 1839
            ||::|.:.:.....:.|:|.::.|....|||||.||.:....:|.|.
 Frog  1131 LAMSYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLALEAPAR------------------ 1177

  Fly  1840 EDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADK 1904
                                                                             
 Frog  1178 ----------------------------------------------------------------- 1177

  Fly  1905 LNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERY 1969
                                               ||:|
 Frog  1178 -----------------------------------IKNK-------------------------- 1181

  Fly  1970 QSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQ 2034
             :.|..|||.|:|.|:|..:||......|:..::..|...::|||.|||||||:|||::||.:::
 Frog  1182 -APPADWPQEGEIKFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKTSLGMALFRLVE 1245

  Fly  2035 TTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKE 2099
            .:.|.|.||.|.|..|...:||::||||||:..||:.|:|.||||...:.:.|:|:.||...:||
 Frog  1246 LSGGCIKIDGVKISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFSQYSEEQIWDALERTHMKE 1310

  Fly  2100 FVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDSSTESALLKAADL 2164
            .| ..|||.|:|.:.:.|.|.|.|.|||:|:||.:||....|:|||||:.:|:.|:..:.:....
 Frog  1311 CV-AQLPLKLETEVLENGENFSVGERQLMCIARVLLRRCKILILDEATAAMDTETDLLIQETIRE 1374

  Fly  2165 AFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEGSVF 2212
            ||...|::||||||.|:|..||::||.||:::|...|..|...|.:.|
 Frog  1375 AFAECTMLTIAHRLHTVLSCDRIMVLAQGQVMEYDTPSALLSNENTRF 1422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
abcc5	XP_012818083.1	PLN03130	101..1425	CDD:215595	447/2030 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010