DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sur and abcc1

DIOPT Version :9

Sequence 1:	NP_001334732.1	Gene:	Sur / 34350	FlyBaseID:	FBgn0028675	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	XP_001341895.3	Gene:	abcc1 / 100002010	ZFINID:	ZDB-GENE-050517-15	Length:	1518	Species:	Danio rerio

Alignment Length:	2237	Identity:	503/2237 - (22%)
Similarity:	814/2237 - (36%)	Gaps:	824/2237 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 IFLLLFGLMFVCSRYKKCHKT--LLTFHNGRA--AISLLLLALNSFDLARIFLPHQNVRNLNRLF 103
            ::|.||..:::.  |.|.|..  :...|..||  .|...|..:...|:...|....:...:..::
Zfish    44 LYLWLFAPLYIL--YLKSHDRGYICMTHLNRAKTVIGFTLWLICWADVFYSFWERSHGATVAPVY 106

  Fly   104 QSSPRDLNYLVVIGSGELWNALFSTLLTLMLMLYHRMVERKKATVFL--YASTAVEA-LTF---- 161
            ..||..|.              .:.||...|:.|.||...:.:.|.|  :..|.|.| :||
Zfish   107 LVSPTMLG--------------VTMLLATFLIQYERMKGVQSSGVMLNFWLITIVCATITFRSKI 157

  Fly   162 --ALLSNELFELVRYEDFLELQTCLVAMSAMCMVSLAMLDGLTVYKECYHDDYLDDYGKIGYKHS 224
              ||.......:.||..|....|.|:    :.::...:.|...::.|...|..       ....|
Zfish   158 MHALNDPASVGVFRYTTFYIYYTLLL----ISLILACLSDQPPLFSEVVKDSN-------PCPES 211

  Fly   225 MATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSA------------------RSHYDHFL 271
            .|:|.||..|||:|.|:..|||.|||.:||..:..||.:                  :...|..|
Zfish   212 GASFLSKITFWWITGLMVKGYKRPLEEKDLWSLNNEDKSERVVPQLVRRWDQECVKVKRPVDKTL 276

  Fly   272 Y--------------------IYTEKKKKSNSSPSLWYCYIKNSWQMFALGGILKLAGDLFALIG 316
            |                    |...|..:....|||::...:.....|.:..:.|:..|:...:|
Zfish   277 YSPKRSTRGEKKDGQPVEESEILLAKALQKTGEPSLFFALCRTFGPYFLVSSLYKIIHDVLMFVG 341

  Fly   317 PLAIQKIVEYIEQLYAQASEPPAKSPGNEVANVLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSD 381
            |..::.::     |:...|..|                                       ||
Zfish   342 PEILRLLI-----LFVNDSSAP---------------------------------------TW-- 360

  Fly   382 LLANGWCIAWIVLLAAITQGALSQASTHILNMTGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAG 446
               :|:....::.:....|..:.|...|:..:||:|::|::.|.:|||:|::.         :|.
Zfish   361 ---HGYFYTALLFVCTCLQTLILQKYFHVCFVTGMRLRTAIVGAVYRKALVIT---------NAA 413

  Fly   447 QVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIP 511
            :..||                               :|.|.|.|:.|.:..|:....|:..|:.|
Zfish   414 RRTST-------------------------------VGEIVNLMSVDAQRFMDLITYINMIWSAP 447

  Fly   512 FKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFFIGNAMSKNAEVIAGY--TDERLKRIHDTLV 574
            .::.:.:|.|:.|||.| |:..:|.:|:|.||...|  ||......:|..  .|.|:|.:::.|.
Zfish   448 LQVILALYFLWQNLGAS-VLAGVAVMVLMVPLNAVI--AMKTKTYQVAQMKSKDNRIKLMNEVLN 509

  Fly   575 GIKVIKLNAWDEVFLKKIQEARRKELKYLNKDATFWTLMAVLTHIATVLITFVTLGVYVWLHRDQ 639
            ||||:||.||:..|..|:...|..||:.|.|.|....:.......|..|:...|..|||.:  |:
Zfish   510 GIKVLKLYAWELAFKGKVSAIRESELRVLKKMAYLGAISTFTWVCAPFLVALSTFAVYVLV--DE 572

  Fly   640 EFDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARI 704
            ...|:|.:.|.|||||..|..||.:.|:.:..::.|.||.:||..||
Zfish   573 NNILDAQKAFVSLALFNILRFPLNMLPMVISSMVQASVSMQRLRVFL------------------ 619

  Fly   705 LSKSDASLDMYETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPS 769
                                                                     |.|::...
Zfish   620 ---------------------------------------------------------SHEELDDD 627

  Fly   770 TVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDD 834
            .|:.                        |.:.|:                            ||.
Zfish   628 NVER------------------------PAISGT----------------------------PDS 640

  Fly   835 IAVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMF 899
            |.::  ||.|:|.......:.:::|.   :|:|.|..|||..||||:|||||||.||....|::
Zfish   641 IRIA--DGAFSWSKDDPPTLKRINVS---IPEGALVAVVGHVGSGKSSLLSALLGEMHKQEGSV- 699

  Fly   900 WHKTCTISYVSQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGI 964
             ....:::||.||.|:.|.|:::|||||...:...|..|:|||||.||:|::|.||.:.|||:|:
Zfish   700 -SIKGSVAYVPQQAWIQNATLKDNILFGRETKDSWYQKVVEACALLPDLEILPGGDTTEIGEKGV 763

  Fly   965 NISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHR 1029
            |:||||:||:::|||:|.:.:|.::||||:::|..||:|||:..|........||.:|||..|..
Zfish   764 NLSGGQKQRVSVARAVYCNCSVYLLDDPLSAVDAHVGKHIFEKVIGPQGLLQGRTRVLVTHGLSF 828

  Fly  1030 IKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLL 1094
            :.:|:.::.:.||.:...|||.:: |.:....||:.....       |..|..||::.|:.
Zfish   829 LPQADLILVMVDGEITEMGSYTEL-LGRQGAFAEFLRTYT-------NTEQEEGEESLGDA---- 881

  Fly  1095 KNVSKLGLQRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNL 1159
              |.:.||:                    :|..:....||       |:|:     ||:..|...
Zfish   882 --VPRKGLE--------------------NGGPAALLRQS-------QISL-----NATGAGKTT 912

  Fly  1160 QRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSES 1224
            |:..::                    ||                          ..:|.|.::|:
Zfish   913 QKTEAN--------------------DD--------------------------AAATKTKSAEA 931

  Fly  1225 SSISGDVLSRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAME 1289
            |.::
Zfish   932 SRLT------------------------------------------------------------- 935

  Fly  1290 VANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEE 1354
                      ||.::||
Zfish   936 ----------EADKANT------------------------------------------------ 942

  Fly  1355 SPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQ 1419

Zfish   943 ----------------------------------------------------------------- 942

  Fly  1420 EQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAGLPI----ITIFFITA 1480
                                              |::...::..|::|.|||:    |.:||...
Zfish   943 ----------------------------------GRVKLSVFWEYMKAIGLPLSIFSIFLFFCHH 973

  Fly  1481 LIWQCLRVYTDIWLQQWSNVHGRVASKGHVVLHPSEQDHEVTYYFRMYAAISC---VCIIMALVS 1542
            |    ..:.::.||..|::         ..|::.::...|:.  ..:|.|:..   :.:....||
Zfish   974 L----SSLGSNYWLSLWTD---------DPVVNNTQPKREMR--LGVYGALGISQGIAVFCYSVS 1023

  Fly  1543 TPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFT 1607
            ...|   |..|.|.||..:|..:|...:.||:.||.|.:||||:.:...||..|.:..:..:...
Zfish  1024 VSVG---GILASRYLHQTMLYNVLRSPMSFFERTPSGNLVNRFAKETDTIDSVIPSIIKMFMGSM 1085

  Fly  1608 LLCLSAILINVTITPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGVT 1672
            ...|.:..:.:..||.:.::..|:...|:.:|:||..|:|:::|:|:.:.|||.:|.:||:.|.:
Zfish  1086 FNVLGSCAVILIATPLVAIIIPPLGLLYFFVQRFYVASSRQMKRLESVSRSPVYTHFNETLLGTS 1150

  Fly  1673 TIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRR 1737
            .||||.:|.||.:....|::.|..||.....::|||.|.|:::|.|||..|.:.|:.|.:
Zfish  1151 VIRAFGEQQRFIKESDGRVDHNQKAYFPSIVANRWLAVRLEFVGNCIVTFAALFAVMARN----- 1210

  Fly  1738 HYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAG 1802
                                         ..||.::||:|:|.|.|...|||:|::.:::|....
Zfish  1211 -----------------------------NLSPGIMGLSISYALQVTASLNWLVRMSSELETNIV 1246

  Fly  1803 SVERIAHYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAG 1867
            :|||:..|
Zfish  1247 AVERVKEY--------------------------------------------------------- 1254

  Fly  1868 DVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQ 1932
                                                                       ||..::
Zfish  1255 -----------------------------------------------------------GDTEKE 1260

  Fly  1933 ATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQN 1997
            |..|   :::..|||                           .||..|.|......|||....:.
Zfish  1261 AEWK---LENSNLPP---------------------------GWPTAGHIEIHKFGLRYREDLEL 1295

  Fly  1998 VISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSII 2062
            .|.::::.|..|:::||.||||:|||||.|.||.:::...|.|.||.|:|..:...|||:|::||
Zfish  1296 AICDISVNIAGGEKVGIVGRTGAGKSSLTLGLFRIIEAAEGEIRIDGVNIADLGLHELRSRITII 1360

  Fly  2063 PQDVHLFNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQL 2127
            |||..||:.::|.||||...:.|.::|..||||.||.||:| ||..|:....:||.|||.|.|||
Zfish  1361 PQDPVLFSGSLRMNLDPFDGYTDEEVWRSLELAHLKTFVSG-LPDKLNHECSEGGENLSLGQRQL 1424

  Fly  2128 LCLARAILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQ 2192
            :|||||:||.:..|||||||:.:|..|::.:.......|...|::||||||.||:||.|::|||:
Zfish  1425 VCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDK 1489

  Fly  2193 GRIVEDGNPRELQQLEGSVFRGLLEKG 2219
            |::.|..:|..|...:|..::...:.|
Zfish  1490 GQMAEFDSPSNLIAKKGIFYKMAKDSG 1516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
abcc1	XP_001341895.3	MRP_assoc_pro	7..1517	CDD:188098	503/2237 (22%)
		ABC_membrane	331..595	CDD:279056	86/357 (24%)
		ABCC_MRP_domain1	641..842	CDD:213217	86/207 (42%)
		ABC_membrane	966..1231	CDD:279056	83/316 (26%)
		ABCC_MRP_domain2	1278..1498	CDD:213211	101/220 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.110