DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13137 and AAAS

DIOPT Version :9

Sequence 1:	NP_609350.2	Gene:	CG13137 / 34349	FlyBaseID:	FBgn0032188	Length:	440	Species:	Drosophila melanogaster
Sequence 2:	XP_011537080.1	Gene:	AAAS / 8086	HGNCID:	13666	Length:	560	Species:	Homo sapiens

Alignment Length:	482	Identity:	110/482 - (22%)
Similarity:	188/482 - (39%)	Gaps:	106/482 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TNAPICNNQQQ---RCVDFVRNNANIGNRTEEVLNLLWELAN---EYWQWFLQKLGQLKRLC--- 66
            |.....::::|   ||::..|:....|     |||   |:||   |.::|.....|....||
Human    65 TRTAFIHHREQVWKRCINIWRDVGLFG-----VLN---EIANSEEEVFEWVKTASGWALALCRWA 121

  Fly    67 ------------FRPECRIDPEILERISQTRGWKTSVIRFIECHPSSSLMAFLTNDDVVLICDKN 119
                        .|.|     :::...:|...|.:..:|....||.::..|....||.|.:.:.:
Human   122 SSLHGSLFPHLSLRSE-----DLIAEFAQVTNWSSCCLRVFAWHPHTNKFAVALLDDSVRVYNAS 181

  Fly   120 YDCPTKIQSVRQKDTTCVAFRPWSQTCEFAVGCAAGICLWS-DSRRLNANRNIRRMMGTHHLQVL 183
            ......::...|::...:|::|.|.:. .||.|.:.|.:|: |...|:.    |...|.  .|||
Human   182 STIVPSLKHRLQRNVASLAWKPLSASV-LAVACQSCILIWTLDPTSLST----RPSSGC--AQVL 239

  Fly   184 QDKGHNYVTSMQWNEDGTILVTAAFGSSHIMLWEPDCQQKIRLIPNP--KSLGSFSLLRFSPDFH 246
            ...||..|||:.|...|..|::|:...:.|.:|:...:   ..:|.|  :..|..:|| :|||..
Human   240 SHPGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTE---TCVPLPWFRGGGVTNLL-WSPDGS 300

  Fly   247 VLFCAS-------CDAGASLCQLNRSKWKLKQILGQQRIQSAVWTTCGSTLLYACYGSTRVYSCT 304
            .:...:       .:|....|:    :|  ..:.|  |.|:..|:..||.||:...|...:||.:
Human   301 KILATTPSAVFRVWEAQMWTCE----RW--PTLSG--RCQTGCWSPDGSRLLFTVLGEPLIYSLS 357

  Fly   305 -----SDGEDSVFLRPQSIWRVQLIMDLQLVT--TCAGQRLCCGEPQCLAMDPLGIYMASIFKEQ 362
                 .:|:..|    .......::.||...|  |..|:....||...:..||.|..:|.:.|.:
Human   358 FPERCGEGKGCV----GGAKSATIVADLSETTIQTPDGEERLGGEAHSMVWDPSGERLAVLMKGK 418

  Fly   363 SFV-----LLCILHTSRWGNVKLLPVEFIY--CDMDGDQYPAYISFGVLKAE-------IRF--- 410
            ..|     ::.:..|......:|||...:.  |.:      .:.|.|:::.|       |.|
Human   419 PRVQDGKPVILLFRTRNSPVFELLPCSLLASGCLL------TFSSSGIIQGEPGAQPQLITFHPS 477

  Fly   411 ------LIIAWNTG---HFQRYDITAQ 428
                  |.:.|:||   |...|.:.||
Human   478 FNKGALLSVGWSTGRIAHIPLYFVNAQ 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13137	NP_609350.2	WD40	89..357	CDD:295369	68/284 (24%)
		WD40	89..>333	CDD:225201	61/260 (23%)
		WD40 repeat	135..178	CDD:293791	12/43 (28%)
		WD40 repeat	191..229	CDD:293791	9/37 (24%)
		WD40 repeat	237..274	CDD:293791	8/43 (19%)
AAAS	XP_011537080.1	WD40	<133..343	CDD:295369	55/233 (24%)
		WD40	154..>413	CDD:225201	68/281 (24%)
		WD40 repeat	157..193	CDD:293791	6/35 (17%)
		WD40 repeat	197..243	CDD:293791	15/52 (29%)
		WD40 repeat	247..283	CDD:293791	10/38 (26%)
		WD40 repeat	291..328	CDD:293791	8/43 (19%)
		WD40 repeat	356..390	CDD:293791	6/37 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158865
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2139
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D470197at33208
OrthoFinder	1	1.000	-	-		FOG0005612
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14494
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.810