DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13137 and Aaas

DIOPT Version :9

Sequence 1:	NP_609350.2	Gene:	CG13137 / 34349	FlyBaseID:	FBgn0032188	Length:	440	Species:	Drosophila melanogaster
Sequence 2:	XP_008763926.1	Gene:	Aaas / 300259	RGDID:	1308701	Length:	560	Species:	Rattus norvegicus

Alignment Length:	476	Identity:	111/476 - (23%)
Similarity:	186/476 - (39%)	Gaps:	108/476 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TNAPICNNQQQ---RCVDFVRNNANIGNRTEEVLNLLWELAN---EYWQWFLQKLGQLKRLCFR- 68
            |.|...::::|   ||::...:....|     |||   |:||   |.::|..........||.|
  Rat    79 TRAAFIHHREQVWKRCINVWHDVGLFG-----VLN---EIANSEEEVFEWVKTASSWALALCGRA 135

  Fly    69 --------PECRIDPE-ILERISQTRGWKTSVIRFIECHPSSSLMAFLTNDDVVLICDKNYDCPT 124
                    |...:..| ::...:|...|.:..:|....||.::..|....||.:.:.:.|.....
  Rat   136 SSLHGSLFPHLSLRSEDLIAEFAQVTNWSSCCLRVFAWHPHTNKFAVALLDDSIRVYNANSTIVP 200

  Fly   125 KIQSVRQKDTTCVAFRPWSQTCEFAVGCAAGICLWS-DSRRLNANRNIRRMMGTHHLQVLQDKGH 188
            .::...|::...:|::|.|.:. .||.|.:.|.:|: |...|:.    |...|.  .|||...||
  Rat   201 SLKHRLQRNVAALAWKPLSASV-LAVACQSCILIWTLDPTSLST----RPSSGC--AQVLSHPGH 258

  Fly   189 NYVTSMQWNEDGTILVTAAFGSSHIMLWEPDCQQKIRLIPNP--KSLGSFSLLRFSPDFHVLFCA 251
            ..|||:.|..:|..|::|:...:.|::|:...:   ..:|.|  :..|..:|| :|||
  Rat   259 TPVTSLAWAPNGGWLLSASPVDAVILVWDVSTE---TCVPLPWFRGGGVTNLL-WSPD------- 312

  Fly   252 SCDAGASLCQLNRSK----WKLKQ--------ILGQQRIQSAVWTTCGSTLLYACYGSTRVYS-- 302
                |:.:.....|.    |:.:.        :.|  |.|:..|:..|..||:...|...:||
  Rat   313 ----GSKVLATTPSAVFRVWEARMWTCEGWPTLSG--RCQTGCWSPDGKRLLFTVLGEALIYSLS 371

  Fly   303 ----CTSD-----GEDSVFLRPQSIWRVQLIMDLQLVT--TCAGQRLCCGEPQCLAMDPLGIYMA 356
                |.::     |..|          ..::.||...|  |..|:....||...:..||.|..:|
  Rat   372 FPEPCGTEKGHVGGAKS----------ATIVADLSETTIQTPDGEERLGGEAHAMVWDPSGERLA 426

  Fly   357 SIFKEQSFV-----LLCILHTSRWGNVKLLPVEFIYCDMDGDQ------YPAYISFGVLKAEIRF 410
            .:.|....|     ::.:..|......:|||...|..: .|.|      :||: :.|.|
  Rat   427 VLMKGNPRVQDGNPVILLFRTRNSPVFELLPCGVIQGE-PGAQAQLVSFHPAF-NKGAL------ 483

  Fly   411 LIIAWNTG---HFQRYDITAQ 428
            |.:.|:||   |...|.:.||
  Rat   484 LSVCWSTGRITHIPLYFVNAQ 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13137	NP_609350.2	WD40	89..357	CDD:295369	68/295 (23%)
		WD40	89..>333	CDD:225201	61/271 (23%)
		WD40 repeat	135..178	CDD:293791	12/43 (28%)
		WD40 repeat	191..229	CDD:293791	9/37 (24%)
		WD40 repeat	237..274	CDD:293791	8/48 (17%)
Aaas	XP_008763926.1	WD40	168..>358	CDD:225201	50/213 (23%)
		WD40	169..>382	CDD:295369	56/236 (24%)
		WD40 repeat	171..207	CDD:293791	6/35 (17%)
		WD40 repeat	211..257	CDD:293791	15/52 (29%)
		WD40 repeat	261..297	CDD:293791	10/38 (26%)
		WD40 repeat	305..342	CDD:293791	8/48 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352864
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2139
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D470197at33208
OrthoFinder	1	1.000	-	-		FOG0005612
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14494
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.810