Protein Alignment CG4839 and YPK2

DIOPT Version :10

• Sequence 1: NP_609349.1
• Gene: CG4839 / 34348
• FlyBaseID: FBgn0032187
• Length: 1003
• Species: Drosophila melanogaster
• Sequence 2: NP_013822.1
• Gene: YPK2 / 855130
• SGDID: S000004710
• Length: 677
• Species: Saccharomyces cerevisiae
• Alignment Length: 711
• Identity: 166/711 - (23%)
• Similarity: 297/711 - (41%)
• Gaps: 123/711 - (17%)

  Fly   347 QQKQQEQQQQQEIQQDATNSQDQMAGAEESHKSSDSSTPKTHRVEGGLIYVRPNFPIQSDIEIES 411
            :.|:.:...:.|.::...|........|:.|..|    ||.|..|             .:..|..
Yeast    13 RSKEDDGSSEDENEKSWGNGLFHFHHGEKHHDGS----PKNHNHE-------------HEHHIRK 60

  Fly   412 IAKDEGTRNLIRTAIERNDFLNNLMDKERKEMVINAMAPASYRKHSLIIREHEEGSEIYVSAEGQ 476
            |..:|...:.:.:...|||                    ||::..|.|..::.:.||...|...
Yeast    61 INTNETLPSSLSSPKLRND--------------------ASFKNPSGIGNDNSKASERKASQSS- 104

  Fly   477 YDVIRGGQLVASFGPATVFGELAILYNAPRQASIEAATDARVWKIARETFRAIMQISGSREREEN 541
                     ..:.||::..|.:.:...:.:..::.....:.. .|.::...:.:..|.|.:..|.
Yeast   105 ---------TETQGPSSESGLMTVKVYSGKDFTLPFPITSNS-TILQKLLSSGILTSSSNDASEV 159

  Fly   542 LQFLRSAPFLQEFDQSLLLKVVDLLQRKFYE--TDSCIVREGELGNE----FYIIRCGTVTIKKL 600
            ...:|..|..:..||....:  .|:.|.|..  ..|.|:..|...:.    |.|....::|....
Yeast   160 AAIMRQLPRYKRVDQDSAGE--GLIDRAFATKFIPSSILLPGSTNSSPLLYFTIEFDNSITTISP 222

  Fly   601 DEQQQEQIVANR-KRGDYFGEQALLNADVRQASVYADAPGTEVLMLDREAFISYLG----TIKQL 660
            |....||.|.|: ...|...:...|..|     |:|..|.   |:|..:.:...:|    .:|::
Yeast   223 DMGTMEQPVFNKISTFDVTRKLRFLKID-----VFARIPS---LLLPSKNWQQEIGEQDEVLKEI 279

  Fly   661 REK--------------PSSQRNDTSGRSSTKS---LEFDNEYSQ--------------VAISEL 694
            .:|              |.:.:.|::.:....:   :..:..|.:              ::|.:.
Yeast   280 LKKINTNQDIHLDSFHLPLNLKIDSAAQIRLYNHHWISLERGYGKLNITVDYKPSKNKPLSIDDF 344

  Fly   695 KKIATLGCGAFGRVDLVAY--NQQALALKIIKKIEVVKQDQIEHVYNEKNVM--IKCRQSPFIVQ 755
            ..:..:|.|:||:|..|..  .|:..|||.::|..:|.:.::.|...|:.|:  :.|   ||||.
Yeast   345 DLLKVIGKGSFGKVMQVRKKDTQKIYALKALRKAYIVSKCEVTHTLAERTVLARVDC---PFIVP 406

  Fly   756 LYRTYRNDKYVYFLMEACMGGDVWTVMSKRQYFDEKTAKFIAGCVVEAFDYLHSHHFIYRDLKPE 820
            |..::::.:.:|.::....||:::..:.....|....::|....::.|.|.||....||||||||
Yeast   407 LKFSFQSPEKLYLVLAFINGGELFYHLQHEGRFSLARSRFYIAELLCALDSLHKLDVIYRDLKPE 471

  Fly   821 NLMLGTDGYCKLVDFGFAKF-VRQNEKTNTFAGTPEYVAPEIILDRGHDRAVDYWALGILVYELL 884
            |::|...|:..|.|||..|. ::.|:||:||.|||||:||||:|.:|:.:.||:|.||||:||::
Yeast   472 NILLDYQGHIALCDFGLCKLNMKDNDKTDTFCGTPEYLAPEILLGQGYTKTVDWWTLGILLYEMM 536

  Fly   885 VGKTPFRGVNQIKIYQQILSGIDVIHMPSRIPKSAQHLVRHLCKQLPAERLGYQRKGIADIKRHS 949
            .|..|:...|...:|::||.  ..:..|.....:|:.|:..|..:.|:.|||.  .|..:|:.|.
Yeast   537 TGLPPYYDENVPVMYKKILQ--QPLLFPDGFDPAAKDLLIGLLSRDPSRRLGV--NGTDEIRNHP 597

  Fly   950 WFESLDWQRLKLKQLPSPIKRPLKSWTDLQYFGP--------SGVENDY---EPPEELSGW 999
            :|:.:.|::|.||....|.|..:||..|...|..        ..|.::|   ...::..||
Yeast   598 FFKDISWKKLLLKGYIPPYKPIVKSEIDTANFDQEFTKEKPIDSVVDEYLSASIQKQFGGW 658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4839	NP_609349.1	CAP_ED	431..539	CDD:237999	13/107 (12%)
		CAP_ED	550..663	CDD:237999	26/123 (21%)
		STKc_cGK	700..957	CDD:270724	89/261 (34%)
YPK2	NP_013822.1	YPK1_N_like	114..339	CDD:212165	37/235 (16%)
		Protein Kinases, catalytic domain	349..660	CDD:473864	103/317 (32%)