DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4839 and NTE1

DIOPT Version :9

Sequence 1:	NP_609349.1	Gene:	CG4839 / 34348	FlyBaseID:	FBgn0032187	Length:	1003	Species:	Drosophila melanogaster
Sequence 2:	NP_013652.1	Gene:	NTE1 / 854943	SGDID:	S000004524	Length:	1679	Species:	Saccharomyces cerevisiae

Alignment Length:	1006	Identity:	188/1006 - (18%)
Similarity:	355/1006 - (35%)	Gaps:	288/1006 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 RKFRTNKDKLQAQDACPSGGSAINVIRSSSKLKPVKERRPTALPTE--VPSIEIEDVRDAKDTGD 161
            |||:|......:.|..|...::    .:|||||    :.|.|.|::  :.|::|.:. :|..:.:
Yeast   490 RKFKTVDKSSGSADLEPKPKNS----NASSKLK----KPPKAKPSDGIIQSLKIANA-NANTSSN 545

  Fly   162 GMD--------------SLGERVQ--PG-------ANAHVDVVDGGGKSKLKVNVNGIIDESVAH 203
            .:.              .||.|.|  ||       .:..:|::..........|.:..|:.|.::
Yeast   546 SLSLKPEFTHHPSSRHVVLGSRDQFNPGDLLSNVPLSRTMDILSPNPIHNNNRNKSNGINTSTSN 610

  Fly   204 DDDYDTPSSNSIATTPVTEGPVKFFIGHTQEL-SAQQTDDTLSCQSSDANNN---SAAKLTNGVV 264
            .....:.||::.|:.     ..|.|...:.|| :||.:...||..::..:::   |...|...|.
Yeast   611 QHKRSSRSSSNNASV-----HSKKFSSLSPELRNAQLSTSPLSLDNTSVHDHIHPSPVHLKGRVS 670

  Fly   265 P-------------QEQPEREMGKQQALQA----------PPRAKSSSNVSLNYLAKSQTDSQRR 306
            |             ||:.|....:...::|          .....|||..:::.|...|.:....
Yeast   671 PRPNLLPTTSFSAAQEETEDSALRMALVEAMLTYLGVNKSNMSVSSSSIANMSSLNSPQLNEMYS 735

  Fly   307 RRVS----------TMPDINIP---PAPPLPPELLVPGTPLHLRKKRSMERQQQQKQQEQQQQQE 358
            ||.|          |..||::.   .:|...|.:|     ..|.|:.::..::..|.
Yeast   736 RRPSNASFLMSPHCTPSDISVASSFASPQTQPTML-----RILPKEYTISNKRHNKS-------- 787

  Fly   359 IQQDATNSQDQMAGAEESHKSSDSSTPKTHRVEGGLIYVRPNFPIQSDIEIESIAKD-------- 415
                               ||.|...|:.::.|     :.||      ::.|.:.||
Yeast   788 -------------------KSQDKKKPRAYKEE-----LTPN------LDFEDVKKDFAQGIQLK 822

  Fly   416 ---EGTRNLIRTAIERNDFLNNLMDKERKEMVINAMAPASYRKHSLIIREHEEGSEIYVSAEGQY 477
               :||     |.:|:|.....|.      .:|:.....:....|.::....:..:  |||:..:
Yeast   823 FFKKGT-----TIVEQNARGKGLF------YIISGKVNVTTNSSSSVVSSMSKPEQ--VSAQSSH 874

  Fly   478 DVIRG------GQLVASFGPATVFGELAILYNAPRQASIEAATDARVWKIARETFRAIMQISGSR 536
               :|      ..|:.|.|...:.|.|:.|.......:|.|.:|..|..::..|...:..
Yeast   875 ---KGENPHHTQHLLYSVGSGGIVGYLSSLIGYKSFVNIVAKSDVYVGFLSSATLERLFD----- 931

  Fly   537 EREENLQFLRSAPFLQEFDQSLLLKVVDLLQRKFYETDSCIVREGELGNEFYIIRCGTVTIKKLD 601
              :..|.:||.:..|.:...|.|||:...|:.........:..:|:..|..|::..|  .:::|.
Yeast   932 --KYFLIYLRISDSLTKLLSSRLLKLDHALEWVHLRASETLFSQGDSANGIYVVLNG--RLRQLQ 992

  Fly   602 EQQ-------------QEQIVANRKRGDYFGEQALLNADVRQASVYA--DA-----PGT--EVLM 644
            :|.             |..|:....:|:.|||..:|.|..|.:::.|  |:     |.|  |:|.
Yeast   993 QQSLSNSNTSSEEVETQNIILGELAQGESFGEVEVLTAMNRYSTIVAVRDSELARIPRTLFELLA 1057

  Fly   645 LDREAFISYLG-----------TIKQLREKP-SSQRND-TSGRSSTKSLEFDNEYSQVAISELKK 696
            |:..:.:..:.           |:..|...| |.:.|| ||....||:     .||. ::|...:
Yeast  1058 LEHPSIMIRVSRLVAKKIVGDRTVPALTGDPLSIKENDFTSLIPPTKA-----SYSS-SLSHKPQ 1116

  Fly   697 IATLGCGAFGRVDLVAYNQ----QALALKIIKKIEVVKQDQI------------EHVYNEKNVMI 745
            ..|.|...|..:.::....    :|.|:|:::..:.|.:..|            .|.::.   :.
Yeast  1117 NITSGTITFRTITILPITSGLPVEAFAMKLVQAFKQVGRTTIGLNQRTTLTHLGRHAFDR---LS 1178

  Fly   746 KCRQSPFIVQLYRTYRNDKYVYFL------MEACMG-GDVWTVMS------------KRQYFDEK 791
            |.:||.:..:|...|:...|:...      ...|:. ||...:::            ::...:.|
Yeast  1179 KLKQSGYFAELEEMYQTVVYISDTPVKSNWTRTCIAQGDCILLLADARSPSAEIGEYEKLLLNSK 1243

  Fly   792 TA-----------KFIAGCVVEAF----DYLHSHHFIYRDLKPENLMLGTDGYC----------- 830
            |.           :::...:...:    .::||||.|...|....||  .:|..
Yeast  1244 TTARTELILLHPERYVEPGLTHKWLRYRPWVHSHHHIQFSLTGTTLM--NEGKMHVLNNGALALM 1306

  Fly   831 -KLVDFGFAKFVRQNEK---TNTFAGTPEYVAPEIILDRG------HDRAVDYWALGILV----Y 881
             ||:...|::..:||..   .::...|.|..:...:..:.      |....|:..|..::    .
Yeast  1307 DKLIQTEFSRKTQQNISKLLPDSIKNTVENFSSRFMKSKRQYYTPVHRHKNDFLRLARILSGQAI 1371

  Fly   882 ELLVGKTPFRGVNQIKIYQQILS---GIDVI 909
            .|::|....||::.:.:.|.|..   .:|||
Yeast  1372 GLVLGGGGARGISHLGVIQAIEEQGIPVDVI 1402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4839	NP_609349.1	Crp	428..577	CDD:223736	28/154 (18%)
		CAP_ED	431..539	CDD:237999	18/113 (16%)
		Crp	544..>650	CDD:223736	30/127 (24%)
		CAP_ED	550..663	CDD:237999	30/145 (21%)
		S_TKc	695..951	CDD:214567	48/293 (16%)
		STKc_cGK	700..957	CDD:270724	47/288 (16%)
NTE1	NP_013652.1	cNMP_binding	821..933	CDD:394984	23/134 (17%)
		CAP_ED	957..1067	CDD:237999	23/111 (21%)
		Pat_Fungal_NTE1	1361..1629	CDD:132865	10/42 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900