DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4839 and RPS6KB1

DIOPT Version :10

Sequence 1:NP_609349.1 Gene:CG4839 / 34348 FlyBaseID:FBgn0032187 Length:1003 Species:Drosophila melanogaster
Sequence 2:NP_003152.1 Gene:RPS6KB1 / 6198 HGNCID:10436 Length:525 Species:Homo sapiens


Alignment Length:349 Identity:110/349 - (31%)
Similarity:179/349 - (51%) Gaps:27/349 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly   655 GTIKQLREKPSSQRNDTSGRSSTKSLEFDNEY-SQVAISE--------------LKKIATLGCGA 704
            |:..:|.|  ..|.|::.........|...|: .:..|||              .:.:..||.|.
Human    39 GSEDELEE--GGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGG 101

  Fly   705 FGRVDLV-----AYNQQALALKIIKKIEVVKQ-DQIEHVYNEKNVMIKCRQSPFIVQLYRTYRND 763
            :|:|..|     |...:..|:|::||..:|:. ....|...|:|::.:.:. ||||.|...::..
Human   102 YGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKH-PFIVDLIYAFQTG 165

  Fly   764 KYVYFLMEACMGGDVWTVMSKRQYFDEKTAKFIAGCVVEAFDYLHSHHFIYRDLKPENLMLGTDG 828
            ..:|.::|...||:::..:.:...|.|.||.|....:..|..:||....|||||||||:||...|
Human   166 GKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQG 230

  Fly   829 YCKLVDFGFAK-FVRQNEKTNTFAGTPEYVAPEIILDRGHDRAVDYWALGILVYELLVGKTPFRG 892
            :.||.|||..| .:.....|:||.||.||:||||::..||:||||:|:||.|:|::|.|..||.|
Human   231 HVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTG 295

  Fly   893 VNQIKIYQQILSGIDVIHMPSRIPKSAQHLVRHLCKQLPAERLGYQRKGIADIKRHSWFESLDWQ 957
            .|:.|...:||.  ..:::|..:.:.|:.|::.|.|:..|.|||.......:::.|.:|..::|:
Human   296 ENRKKTIDKILK--CKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWE 358

  Fly   958 RLKLKQLPSPIKRPLKSWTDLQYF 981
            .|..:::..|.|..|:|..|:..|
Human   359 ELLARKVEPPFKPLLQSEEDVSQF 382

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4839NP_609349.1 CAP_ED 431..539 CDD:237999
CAP_ED 550..663 CDD:237999 2/7 (29%)
STKc_cGK 700..957 CDD:270724 92/263 (35%)
RPS6KB1NP_003152.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..54 5/16 (31%)
TOS motif 28..32
STKc_p70S6K 94..416 CDD:270736 100/292 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 380..399 1/3 (33%)
Autoinhibitory domain 424..525
Blue background indicates that the domain is not in the aligned region.

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