Protein Alignment CG4839 and pnpla6

DIOPT Version :10

• Sequence 1: NP_609349.1
• Gene: CG4839 / 34348
• FlyBaseID: FBgn0032187
• Length: 1003
• Species: Drosophila melanogaster
• Sequence 2: XP_005160109.1
• Gene: pnpla6 / 560986
• ZFINID: ZDB-GENE-050107-4
• Length: 1343
• Species: Danio rerio
• Alignment Length: 748
• Identity: 143/748 - (19%)
• Similarity: 254/748 - (33%)
• Gaps: 210/748 - (28%)

  Fly   146 PSIEIEDVRDAK----DTG-DGMDSLGERVQPGANAHVDVVDGGGKSKLKVNVNGIIDESVAHDD 205
            |...|..|:|.|    .|| ||.|.:.:.|.||.:.|              ::..|:|....|..
Zfish   203 PDSSIYVVQDGKLELCLTGQDGKDGVVKEVYPGDSVH--------------SLLSILDVITGHQR 253

  Fly   206 DYDTPSSNSIATTPVTEGPVKFF---------------------------------IGHTQELSA 237
            .|.|.|:.:...:.|...||..|                                 :|.|.||.:
Zfish   254 PYKTVSARAAEVSTVLRLPVDAFLSIFEKYPESLVRVVQIIMVRLQRVTVLALHNYLGLTNELFS 318

  Fly   238 QQTDDTLSCQSSDANNNSAAKLTNGVVPQEQPEREMGKQQALQAPPRAKSSSNVSLNYLAKSQTD 302
            .:.....|..|.....:|             |.|...:..:|..|.:.:.::       .::.|.
Zfish   319 HEMQPRSSPLSPHPTRSS-------------PVRHSKRFGSLTVPDKHREAA-------VQNATG 363

  Fly   303 SQRRRRVSTMPDINIPPAPPLPPELLVPGTPLHLRKKRSM--ERQQQQKQQE--------QQQQQ 357
            ....:...|:|.::...:.|:.    :.|....||....|  ||.:.....|        :|:::
Zfish   364 GDHGKEGGTIPTLSRTISMPVD----IAGMQKSLRSDFDMAYERGRISVSAEDGVPAFTKEQRER 424

  Fly   358 EIQQDATNSQDQMAGAEESHKSSDSSTPKTHRVEGGLIYVRPNFPIQSDIEIESIAKDEGTRNLI 422
            ::..|...|...:...|||.....||      .:|     |||          :...:|..:.::
Zfish   425 KVTVDEVPSGVYLYPEEESGMDIFSS------FQG-----RPN----------ATVFEEAQKEIL 468

  Fly   423 RTAIERNDFLNNLMDKERKEMVINAMAPASYRKHSLIIREHEEGSEIYVSAEGQYDV----IRGG 483
            |           ||..|...::...:.....:..|::.|:.::...::....|...|    |...
Zfish   469 R-----------LMKIEDPSLLNGRVTFHHAKAGSVLARQGDQDVSLHFVLSGCLHVYQKMIDKQ 522

  Fly   484 QLVASF--GPATVFGELAILYNAPRQASIEAATDARVWKIARETFRAIMQISGSREREE------ 540
            :.|..|  .|..:.|:||:|...|...:|:|..|....||::..|..||     ||:..
Zfish   523 EAVCLFVTQPGEMVGQLAVLTGEPLIFTIKAERDCTFLKISKSEFYEIM-----REQPSVVLSAA 582

  Fly   541 NLQFLRSAPFLQEFDQSLLLKVVDLLQRKFYETDSCIVREGELGNEFYIIRCGTV--TIKKLDEQ 603
            :...:|.:.|:::.|.::....|        |....:.|:.:..:..||:..|.:  .|:|.:
Zfish   583 HTVAIRMSAFVRQMDFAIDWMAV--------EAGRALYRQDDQSDCTYIVLNGRLRSVIRKAN-- 637

  Fly   604 QQEQIVANRKRGDYFGEQALLNADVRQASVYADAPGTEVLMLDREAFISYLGTIKQ--------- 659
            .::::|....|||..|....|....|..:|:| ...||::.|..    ..|..||:
Zfish   638 GKKELVGEYGRGDLIGVVEALTRQPRATTVHA-VRDTELVKLPE----GTLNNIKRRYPQVVTRL 697

  Fly   660 ---LREKPSSQRNDTSGRSSTKSLEFDNEYSQVAI----SELKKIATLG-CGAFGRVDLVAYNQQ 716
               |.:|.........|..|:.:|...:..|...:    |.|..:|.|. |   ..|.:.|:|.:
Zfish   698 IHLLGQKILGNLQQPRGPFSSSALGLPSMASSPDVTNPASNLSTVAVLPVC---DEVPINAFNLE 759

  Fly   717 ------ALALKIIKKIEVVKQ-------DQIEHVYNEKNVMIKCRQSPFIVQLYRTYRNDKYVYF 768
                  |:...::...:::::       |.| |.|         |.|.::.|     :.|.....
Zfish   760 LSHALSAIGPTLLLTSDIIRERLGASALDSI-HEY---------RLSGWLAQ-----QEDINRIV 809

  Fly   769 LMEACMGGDVWTVMSKRQYFDEKTAKFIAGCVV 801
            |.:...|...||....||          |.|::
Zfish   810 LYQTDSGMTPWTQRCIRQ----------ADCIL 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4839	NP_609349.1	CAP_ED	431..539	CDD:237999	26/113 (23%)
		CAP_ED	550..663	CDD:237999	26/126 (21%)
		STKc_cGK	700..957	CDD:270724	22/116 (19%)
pnpla6	XP_005160109.1	TM_EGFR-like	31..64	CDD:213052
		CAP_ED	170..291	CDD:237999	24/101 (24%)
		CAP_ED	467..577	CDD:237999	27/125 (22%)
		CAP_ED	590..698	CDD:237999	25/122 (20%)
		Pat_PNPLA6_PNPLA7	921..1226	CDD:132864