Protein Alignment CG4839 and PRKG1

DIOPT Version :10

• Sequence 1: NP_609349.1
• Gene: CG4839 / 34348
• FlyBaseID: FBgn0032187
• Length: 1003
• Species: Drosophila melanogaster
• Sequence 2: NP_006249.1
• Gene: PRKG1 / 5592
• HGNCID: 9414
• Length: 686
• Species: Homo sapiens
• Alignment Length: 684
• Identity: 272/684 - (39%)
• Similarity: 406/684 - (59%)
• Gaps: 24/684 - (3%)

  Fly   336 LRKKRSMERQQ----QQKQQEQQQQQEIQQDATNSQDQ-----MAGAEESHKSSDSSTPKTHRVE 391
            |::|....||:    .:.:.|..|:.|:.|...|..|:     ....:::.|.|.|:.....|.:
Human    11 LQEKIEELRQRDALIDELELELDQKDELIQKLQNELDKYRSVIRPATQQAQKQSASTLQGEPRTK 75

  Fly   392 GGLIYVRPN-FPIQ--SDIEIESIAKDEGTRNLIRTAIERNDFLNNLMDKERKEMVINAMAPASY 453
            ...|...|. |.||  |.:.:....|...:::||:.||..|||:.||...:.:| :::.|.|..|
Human    76 RQAISAEPTAFDIQDLSHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQE-IVDCMYPVEY 139

  Fly   454 RKHSLIIREHEEGSEIYVSAEGQYDVIRGGQLVASFGPATVFGELAILYNAPRQASIEAATDARV 518
            .|.|.||:|.:.||.:||..:|:.:|.:.|..:.:.||..||||||||||..|.|:::...:.::
Human   140 GKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKL 204

  Fly   519 WKIARETFRAIMQISGSREREENLQFLRSAPFLQEFDQSLLLKVVDLLQRKFYETDSCIVREGEL 583
            |.|.|:.|:.||..:|..:..|.::||:|.|..|...:.:|.|:.|:|:...||....|:|:|..
Human   205 WAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGAR 269

  Fly   584 GNEFYIIRCGTVTIKKLDEQQQEQI-VANRKRGDYFGEQALLNADVRQASVYADAPGTEVLMLDR 647
            |:.|:||..|||.:.:.|...::.: :....:||:|||:||...|||.|:|.| |.....|::||
Human   270 GDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIA-AEAVTCLVIDR 333

  Fly   648 EAFISYLGTIKQLREKPSSQRNDTSGRSSTKSLEFDNEYSQVAISELKKIATLGCGAFGRVDLV- 711
            ::|...:|.:..:..| :.:..:...:...::..|.|    :.:|:...|.|||.|.||||:||
Human   334 DSFKHLIGGLDDVSNK-AYEDAEAKAKYEAEAAFFAN----LKLSDFNIIDTLGVGGFGRVELVQ 393

  Fly   712 --AYNQQALALKIIKKIEVVKQDQIEHVYNEKNVMIKCRQSPFIVQLYRTYRNDKYVYFLMEACM 774
              :...:..|:||:||..:|...|.||:.:||.:| :...|.|||:||||:::.||:|.|||||:
Human   394 LKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM-QGAHSDFIVRLYRTFKDSKYLYMLMEACL 457

  Fly   775 GGDVWTVMSKRQYFDEKTAKFIAGCVVEAFDYLHSHHFIYRDLKPENLMLGTDGYCKLVDFGFAK 839
            ||::||::..|..|::.|.:|...||||||.||||...||||||||||:|...||.|||||||||
Human   458 GGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAK 522

  Fly   840 FVRQNEKTNTFAGTPEYVAPEIILDRGHDRAVDYWALGILVYELLVGKTPFRGVNQIKIYQQILS 904
            .:...:||.||.||||||||||||::|||.:.|||:||||:||||.|..||.|.:.:|.|..||.
Human   523 KIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILR 587

  Fly   905 GIDVIHMPSRIPKSAQHLVRHLCKQLPAERLGYQRKGIADIKRHSWFESLDWQRLKLKQLPSPIK 969
            |||:|..|.:|.|:|.:|::.||:..|:||||..:.|:.||::|.|||..:|:.|:...|..||.
Human   588 GIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPII 652

  Fly   970 RPLKSWTDLQYFGPSGVENDYEPPEELSGWDKDF 1003
            ..:.|.||...|.....:||..||::.||||.||
Human   653 PSVASPTDTSNFDSFPEDNDEPPPDDNSGWDIDF 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4839	NP_609349.1	CAP_ED	431..539	CDD:237999	40/107 (37%)
		CAP_ED	550..663	CDD:237999	37/113 (33%)
		STKc_cGK	700..957	CDD:270724	138/259 (53%)
PRKG1	NP_006249.1	DD_cGKI-beta	4..55	CDD:213375	10/43 (23%)
		CAP_ED	118..227	CDD:237999	40/109 (37%)
		CAP_ED	237..341	CDD:237999	36/104 (35%)
		STKc_cGK	381..641	CDD:270724	139/260 (53%)
		S_TK_X	636..>679	CDD:214529	13/42 (31%)