DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4839 and PRKAR2B

DIOPT Version :9

Sequence 1:	NP_609349.1	Gene:	CG4839 / 34348	FlyBaseID:	FBgn0032187	Length:	1003	Species:	Drosophila melanogaster
Sequence 2:	NP_002727.2	Gene:	PRKAR2B / 5577	HGNCID:	9392	Length:	418	Species:	Homo sapiens

Alignment Length:	326	Identity:	95/326 - (29%)
Similarity:	161/326 - (49%)	Gaps:	27/326 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   356 QQEIQQDATNSQDQMAGAEESHKSSDS---STPKTHR-VEGGLIYVRPNFPIQSDIEIES---IA 413
            ::.:|.|   |:|   |.||....:|:   :.|..:| .....:......|.:.:.:.||   ..
Human    78 EEPMQSD---SED---GEEEEAAPADAGAFNAPVINRFTRRASVCAEAYNPDEEEDDAESRIIHP 136

  Fly   414 KDEGTRNLIRTAIERNDFLNNLMDKERKEMVINAMAPASYRKHSLIIREHEEGSEIYVSAEGQYD 478
            |.:..||.::.|.:......|| |.|:...|::||.....:....:|.:.::|...||...|.:|
Human   137 KTDDQRNRLQEACKDILLFKNL-DPEQMSQVLDAMFEKLVKDGEHVIDQGDDGDNFYVIDRGTFD 200

  Fly   479 VI----RGGQLVASFGPATVFGELAILYNAPRQASIEAATDARVWKIARETFRAIMQISGSRERE 539
            :.    ..|:.|.::.....|||||::||.||.|:|.|.:...:|.:.|.|||.|:..:.:::|:
Human   201 IYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRK 265

  Fly   540 ENLQFLRSAPFLQEFDQSLLLKVVDLLQRKFYETDSCIVREGELGNEFYIIRCGTV--TIKKLDE 602
            ....|:.|.|||:..:.|..|||||::..|.|.....|:.:|:..:.|:|:..|.|  |:|:..:
Human   266 MYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVKITMKRKGK 330

  Fly   603 QQQEQ----IVANRKRGDYFGEQALLNADVRQASVYADAPGT-EVLMLDREAFISYLGTIKQLRE 662
            .:.|:    .:|...||.||||.||:....|.||  |.|.|| :.|.:|.:||...||...::.:
Human   331 SEVEENGAVEIARCSRGQYFGELALVTNKPRAAS--AHAIGTVKCLAMDVQAFERLLGPCMEIMK 393

  Fly   663 K 663
            :
Human   394 R 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4839	NP_609349.1	Crp	428..577	CDD:223736	47/152 (31%)
		CAP_ED	431..539	CDD:237999	33/111 (30%)
		Crp	544..>650	CDD:223736	40/112 (36%)
		CAP_ED	550..663	CDD:237999	41/119 (34%)
		S_TKc	695..951	CDD:214567
		STKc_cGK	700..957	CDD:270724
PRKAR2B	NP_002727.2	Dimerization and phosphorylation	2..153		17/80 (21%)
		DD_RIIbeta_PKA	3..43	CDD:213051
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..96		7/23 (30%)
		Crp	150..>259	CDD:223736	33/109 (30%)
		CAP_ED	154..267	CDD:237999	34/113 (30%)
		Crp	270..>385	CDD:223736	42/116 (36%)
		CAP_ED	276..396	CDD:237999	41/121 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000531
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810