DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4839 and PRKAR1B

DIOPT Version :9

Sequence 1:	NP_609349.1	Gene:	CG4839 / 34348	FlyBaseID:	FBgn0032187	Length:	1003	Species:	Drosophila melanogaster
Sequence 2:	NP_001158230.1	Gene:	PRKAR1B / 5575	HGNCID:	9390	Length:	381	Species:	Homo sapiens

Alignment Length:	390	Identity:	111/390 - (28%)
Similarity:	180/390 - (46%)	Gaps:	57/390 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 PPAPPLPPELLVPGTPLHL-------------------RKKRSME--RQQQQKQQEQQQQQEIQQ 361
            |||.|...:..:.|..|::                   :.:|.|:  |:..:|.::::.:|.:.:
Human     4 PPACPSEEDESLKGCELYVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKEENRQILAR 68

  Fly   362 DATNSQDQMAGAEESHKSSDSSTP-----KTHRVEGG-----------LIYVRPNFPIQSDIEIE 410
            ..:|||      .:||....|.||     |..|..||           :.|||...|
Human    69 QKSNSQ------SDSHDEEVSPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIP-------- 119

  Fly   411 SIAKDEGTRNLIRTAIERNDFLNNLMDKERKEMVINAMAPASYRKHSLIIREHEEGSEIYVSAEG 475
               ||..|...:..||.:|....:|.|.||.: :.:||.|.::.....:|::..||...||..:|
Human   120 ---KDYKTMTALAKAISKNVLFAHLDDNERSD-IFDAMFPVTHIAGETVIQQGNEGDNFYVVDQG 180

  Fly   476 QYDVIRGGQLVASFGPATVFGELAILYNAPRQASIEAATDARVWKIARETFRAIMQISGSREREE 540
            :.||...|:.|.:......|||||::|..||.|:::|.||.::|.|.|:::|.|:..|..|:|:.
Human   181 EVDVYVNGEWVTNISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKRKM 245

  Fly   541 NLQFLRSAPFLQEFDQSLLLKVVDLLQRKFYETDSCIVREGELGNEFYIIRCGTVTIKKLDEQQQ 605
            ..:||.....|:..::...|.|.|.|:...:|....||.:||.|::||||..||.::.:.....:
Human   246 YEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQRRSPNE 310

  Fly   606 EQIVANR-KRGDYFGEQALLNADVRQASVYADAPGTEVLMLDREAFISYLGTIKQLREKPSSQRN 669
            |.:...| ...|||||.|||....|.|:|.|..| .:.:.|||..|...||...::.::...:.|
Human   311 EYVEVGRLGPSDYFGEIALLLNRPRAATVVARGP-LKCVKLDRPRFERVLGPCSEILKRNIQRYN 374

Fly 670 669
Human 375 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4839	NP_609349.1	Crp	428..577	CDD:223736	46/148 (31%)
		CAP_ED	431..539	CDD:237999	36/107 (34%)
		Crp	544..>650	CDD:223736	37/106 (35%)
		CAP_ED	550..663	CDD:237999	38/113 (34%)
		S_TKc	695..951	CDD:214567
		STKc_cGK	700..957	CDD:270724
PRKAR1B	NP_001158230.1	Dimerization and phosphorylation	2..136		32/148 (22%)
		DD_RIbeta_PKA	11..64	CDD:213049	6/52 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..98		10/36 (28%)
		Pseudophosphorylation motif	96..100		1/3 (33%)
		CAP_ED	137..246	CDD:237999	37/109 (34%)
		CAP_ED	255..370	CDD:237999	38/115 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000531
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810