DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4839 and LOC556339

DIOPT Version :9

Sequence 1:	NP_609349.1	Gene:	CG4839 / 34348	FlyBaseID:	FBgn0032187	Length:	1003	Species:	Drosophila melanogaster
Sequence 2:	XP_021328301.1	Gene:	LOC556339 / 556339	-ID:	-	Length:	771	Species:	Danio rerio

Alignment Length:	857	Identity:	312/857 - (36%)
Similarity:	446/857 - (52%)	Gaps:	167/857 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 DTPSSNSIATTPVTEG--PVKFFIGHTQELSAQQTDDTLSCQSSDANNNSAAKLTNGVVPQEQPE 270
            :|..::||..|||.|.  |:|..|.|.:|..|::                              :
Zfish    21 ETCLASSIKETPVWESVEPLKMRIAHLEEELARR------------------------------D 55

  Fly   271 REMGKQ----QALQAPPRAKSS------SNVSLNYLAKSQTDSQRRRRVSTMPDINIPPAPPLPP 325
            ||:..|    |:||....||.|      ..:..|.|.:|                  ||||
Zfish    56 RELRAQENQLQSLQRELEAKVSQIDKLQDAIGYNSLGRS------------------PPAP---- 98

  Fly   326 ELLVPGTPLHLRKKRSMERQQQQKQQEQQQQQEIQQDATNSQDQMAGAEESH-----KSSDSSTP 385
                   ..|.|:..|:..|...:....                   |.|.|     |...|:.|
Zfish    99 -------LRHSRRLLSVINQGSMRFHRV-------------------AVEVHRRLKAKEGVSAEP 137

  Fly   386 KT------HRVEGGLIYVRPNFPIQSDIEIESIAKDEGTRNLIRTAIERNDFLNNLMDKERKEMV 444
            .|      ||..            :|..|.:.|.||.||:.||..|:.:||||..|..:..:|||
Zfish   138 TTRHFCHDHRAH------------RSSTERQHIRKDSGTKKLINEALMKNDFLKKLEPQHTREMV 190

  Fly   445 INAMAPASYRKHSLIIREHEEGSEIYVSAEGQYDVIRGGQLVASFGPATVFGELAILYNAPRQAS 509
             :.|....|....|:|:|.|.|:.:||.|||..:||:.|:.:....|.|.|||||||||..|.|:
Zfish   191 -DCMYEKIYGAEQLVIQEGEPGNFLYVLAEGLLEVIQNGKFLGQMRPGTAFGELAILYNCKRTAT 254

  Fly   510 IEAATDARVWKIARETFRAIMQISGSREREENLQFLRSAPFLQEFDQSLLLKVVDLLQRKFYETD 574
            ::|.:.:.:|.:.|:||:.||..|.....||...||||...|::..:..|.|::|.|:..:::..
Zfish   255 VKAVSQSHIWALDRQTFQTIMMRSTQARHEEYFSFLRSVSLLKDLPEEKLAKIIDCLEIDYFDKG 319

  Fly   575 SCIVREGELGNEFYIIRCGTVTIKKLDEQQQE-QIVANRKRGDYFGEQALLNADVRQASVYADAP 638
            ..|:||||.||.|:||..|.|::.:..|...| |.:...:.||||||:||::.|||.|::.|...
Zfish   320 EYIIREGEEGNTFFIIAKGEVSVTQTTEGFTEPQEIKTLRVGDYFGEKALISEDVRSANIIAKEN 384

  Fly   639 GTEVLMLDREAFISYLGTIKQLR---------------------EKPSSQRNDTSGR-------- 674
            .|:.|::||:.|...:||.::|:                     :.|..:|:..:..
Zfish   385 DTQCLVVDRDNFNEMVGTYEELQAYLREYVEELSLSDERRNAVPQSPLYERSPEAAELRRLKEKA 449

  Fly   675 ---SSTKSLEFDNEYSQVAISELKKIATLGCGAFGRVDLVAYNQQ---ALALKIIKKIEVVKQDQ 733
               |||..|:           ||:.:||||.|.||||:||.....   |.|||.|||..:|...|
Zfish   450 TALSSTSFLK-----------ELQVVATLGMGGFGRVELVKLKDSEDTAFALKCIKKKHIVDTRQ 503

  Fly   734 IEHVYNEKNVMIKCRQSPFIVQLYRTYRNDKYVYFLMEACMGGDVWTVMSKRQYFDEKTAKFIAG 798
            .||:|:|| ::::...|.|||:|:||:|:||:||.|:|.|:||::|:::.....|||.||:|..|
Zfish   504 QEHIYSEK-IILQQTNSNFIVRLFRTFRDDKFVYMLLEVCLGGELWSLLRDMSCFDEPTARFCTG 567

  Fly   799 CVVEAFDYLHSHHFIYRDLKPENLMLGTDGYCKLVDFGFAKFVRQNEKTNTFAGTPEYVAPEIIL 863
            ||:|||||||....:|||||||||:|..:||.|:.||||||.:...:||.||.|||||||||:|:
Zfish   568 CVLEAFDYLHGKGIVYRDLKPENLLLDAEGYVKMADFGFAKKIGLGKKTWTFCGTPEYVAPEVIM 632

  Fly   864 DRGHDRAVDYWALGILVYELLVGKTPFRGVNQIKIYQQILSGIDVIHMPSRIPKSAQHLVRHLCK 928
            ::|||...|.|:||||::|||:|..||.|.:.|:||..:|.||:.:.:|.||.|..:.|:|.|||
Zfish   633 NKGHDFGADCWSLGILIFELLIGSPPFTGSDPIRIYTMVLHGIEKVDIPKRISKRPEDLIRRLCK 697

  Fly   929 QLPAERLGYQRKGIADIKRHSWFESLDWQRLKLKQLPSPIKRPLKSWTDLQYFG--PSGVENDYE 991
            ..||||||.::.||.|||:|.||:..:|:.|:.::|.||::|.||...|..||.  |..:|   |
Zfish   698 LNPAERLGNKKNGIIDIKKHKWFQGFNWEGLRRRKLMSPLRRELKGPLDHSYFDMFPPELE---E 759

  Fly   992 PPEELSGWDKDF 1003
            ||:|.|||||||
Zfish   760 PPDEFSGWDKDF 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4839	NP_609349.1	Crp	428..577	CDD:223736	55/148 (37%)
		CAP_ED	431..539	CDD:237999	42/107 (39%)
		Crp	544..>650	CDD:223736	41/106 (39%)
		CAP_ED	550..663	CDD:237999	41/134 (31%)
		S_TKc	695..951	CDD:214567	135/258 (52%)
		STKc_cGK	700..957	CDD:270724	135/259 (52%)
LOC556339	XP_021328301.1	CAP_ED	177..286	CDD:237999	43/109 (39%)
		CAP_ED	295..410	CDD:237999	41/114 (36%)
		STKc_cGK	467..727	CDD:270724	136/260 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123183at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920