DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4839 and Prkg1

DIOPT Version :9

Sequence 1:	NP_609349.1	Gene:	CG4839 / 34348	FlyBaseID:	FBgn0032187	Length:	1003	Species:	Drosophila melanogaster
Sequence 2:	NP_001099201.3	Gene:	Prkg1 / 54286	RGDID:	1587390	Length:	671	Species:	Rattus norvegicus

Alignment Length:	680	Identity:	267/680 - (39%)
Similarity:	404/680 - (59%)	Gaps:	30/680 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   334 LHLRKKRSMERQQQQKQQEQQQQQEIQQDATNSQDQM------AGAEESHKSSDSSTPKTHRVEG 392
            |.|:::|..|.:::..::| ::.||:::.....|..:      .|...:.....|:.|:|:|...
  Rat    12 LMLKEERIKELEKRLSEKE-EEIQELKRKLHKCQSVLPVPSTHIGPRTTRAQGISAEPQTYRSFH 75

  Fly   393 GLIYVRPNFPIQSDIEIESIAKDEGTRNLIRTAIERNDFLNNLMDKERKEMVINAMAPASYRKHS 457
            .|   |..|        ....|.|.:::||:.||..|||:.||...:.:| :::.|.|..|.|.|
  Rat    76 DL---RQAF--------RKFTKSERSKDLIKEAILDNDFMKNLELSQIQE-IVDCMYPVEYGKDS 128

  Fly   458 LIIREHEEGSEIYVSAEGQYDVIRGGQLVASFGPATVFGELAILYNAPRQASIEAATDARVWKIA 522
            .||:|.:.||.:||..:|:.:|.:.|..:.:.||..||||||||||..|.|:::...:.::|.|.
  Rat   129 CIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAID 193

  Fly   523 RETFRAIMQISGSREREENLQFLRSAPFLQEFDQSLLLKVVDLLQRKFYETDSCIVREGELGNEF 587
            |:.|:.||..:|..:..|.::||:|.|..|.....:|.|:.|:|:...||....|:|:|..|:.|
  Rat   194 RQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPDEILSKLADVLEETHYENGEYIIRQGARGDTF 258

  Fly   588 YIIRCGTVTIKKLDEQQQEQI-VANRKRGDYFGEQALLNADVRQASVYADAPGTEVLMLDREAFI 651
            :||..|.|.:.:.|...::.: :....:||:|||:||...|||.|:|.| |.....|::||::|.
  Rat   259 FIISKGKVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIA-AEAVTCLVIDRDSFK 322

  Fly   652 SYLGTIKQLREKPSSQRNDTSGRSSTKSLEFDNEYSQVAISELKKIATLGCGAFGRVDLV---AY 713
            ..:|.:..:..| :.:..:...:...::..|.|    :.:|:...|.|||.|.||||:||   :.
  Rat   323 HLIGGLDDVSNK-AYEDAEAKAKYEAEAAFFAN----LKLSDFNIIDTLGVGGFGRVELVQLKSE 382

  Fly   714 NQQALALKIIKKIEVVKQDQIEHVYNEKNVMIKCRQSPFIVQLYRTYRNDKYVYFLMEACMGGDV 778
            ..:..|:||:||..:|...|.||:.:||.:| :...|.|||:||||:::.||:|.|||||:||::
  Rat   383 ESKTFAMKILKKRHIVDTRQQEHIRSEKQIM-QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGEL 446

  Fly   779 WTVMSKRQYFDEKTAKFIAGCVVEAFDYLHSHHFIYRDLKPENLMLGTDGYCKLVDFGFAKFVRQ 843
            ||::..|..|::.|.:|...||||||.||||...||||||||||:|...||.|||||||||.:..
  Rat   447 WTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGF 511

  Fly   844 NEKTNTFAGTPEYVAPEIILDRGHDRAVDYWALGILVYELLVGKTPFRGVNQIKIYQQILSGIDV 908
            .:||.||.||||||||||||::|||.:.|||:||||:||||.|..||.|.:.:|.|..||.|||:
  Rat   512 GKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDM 576

  Fly   909 IHMPSRIPKSAQHLVRHLCKQLPAERLGYQRKGIADIKRHSWFESLDWQRLKLKQLPSPIKRPLK 973
            |..|.:|.|:|.:|::.||:..|:||||..:.|:.||::|.|||..:|:.|:...|..||...:.
  Rat   577 IEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVA 641

  Fly   974 SWTDLQYFGPSGVENDYEPPEELSGWDKDF 1003
            |.||...|.....::|..||::.||||.||
  Rat   642 SPTDTSNFDSFPEDSDEPPPDDNSGWDIDF 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4839	NP_609349.1	Crp	428..577	CDD:223736	54/148 (36%)
		CAP_ED	431..539	CDD:237999	40/107 (37%)
		Crp	544..>650	CDD:223736	38/106 (36%)
		CAP_ED	550..663	CDD:237999	36/113 (32%)
		S_TKc	695..951	CDD:214567	137/258 (53%)
		STKc_cGK	700..957	CDD:270724	138/259 (53%)
Prkg1	NP_001099201.3	DD_cGKI-alpha	2..49	CDD:213374	8/37 (22%)
		CAP_ED	103..212	CDD:237999	40/109 (37%)
		CAP_ED	222..326	CDD:237999	35/104 (34%)
		STKc_cGK	366..626	CDD:270724	139/260 (53%)
		S_TK_X	621..>664	CDD:214529	12/42 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123183at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010