DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4839 and prkg1a

DIOPT Version :9

Sequence 1:	NP_609349.1	Gene:	CG4839 / 34348	FlyBaseID:	FBgn0032187	Length:	1003	Species:	Drosophila melanogaster
Sequence 2:	XP_005157115.1	Gene:	prkg1a / 394005	ZFINID:	ZDB-GENE-040426-1308	Length:	684	Species:	Danio rerio

Alignment Length:	681	Identity:	269/681 - (39%)
Similarity:	403/681 - (59%)	Gaps:	22/681 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   336 LRKKRSMERQQ----QQKQQEQQQQQEIQQDATNSQDQMAGA---EESHKSSDSSTPKTHRVEGG 393
            |::|....||:    .:.:.|..|:.|:.|...|..|:....   ......:.|..|:..|.:..
Zfish    13 LQEKIEELRQRDALIDELELELDQKDELIQKLQNELDKYRSVIRPATQQVQTRSELPEHQRTKRQ 77

  Fly   394 LIYVRP-NFPIQSDIEIESIAKDEGTRNLIRTAIERNDFLNNLMDKERKEMVINAMAPASYRKHS 457
            .|...| |....|.:.:.::.|...:::||::||..|||:.||...:.:| :::.|.|..|.|:|
Zfish    78 AISAEPANIQQLSHVTLPNVPKSAKSKDLIKSAILDNDFMKNLEMSQIQE-IVDCMYPVDYDKNS 141

  Fly   458 LIIREHEEGSEIYVSAEGQYDVIRGGQLVASFGPATVFGELAILYNAPRQASIEAATDARVWKIA 522
            .||:|.:.||.:||..:|:.:|.:.|..:.:.||..||||||||||..|.|::...:..::|.|.
Zfish   142 CIIKEGDVGSLVYVMEDGKVEVTKEGLKLCTMGPGKVFGELAILYNCTRTATVRTVSSVKLWAID 206

  Fly   523 RETFRAIMQISGSREREENLQFLRSAPFLQEFDQSLLLKVVDLLQRKFYETDSCIVREGELGNEF 587
            |:.|:.||..:|..:..|.::.|:|....:...:.:|.|:.|:|:...||..:.|:|:|..|:.|
Zfish   207 RQCFQTIMMRTGLIKHAEYMELLKSVLTFRGLPEEILSKLADVLEETHYEDGNYIIRQGARGDTF 271

  Fly   588 YIIRCGTVTIKKLDEQQQEQI-VANRKRGDYFGEQALLNADVRQASVYADAPGTEVLMLDREAFI 651
            :||..|.||:.:.|...||.: :.:..|||.|||:||...|:|.|:|.| |.....|::||:::.
Zfish   272 FIISKGKVTMTREDCPGQEPVYLRSMGRGDSFGEKALQGEDIRTANVIA-AETVTCLVIDRDSYK 335

  Fly   652 SYLGTIKQLREKPSSQRNDTSGRSSTKSLEFDNE-YSQVAISELKKIATLGCGAFGRVDLV---A 712
            ..:|.::.:..|..   .|...::   ..|.:|. :|.:.:|:...|.|||.|.||||:||   :
Zfish   336 HLIGGLEDVSNKGC---EDAEAKA---KYEAENAFFSNLNLSDFNIIDTLGVGGFGRVELVQLKS 394

  Fly   713 YNQQALALKIIKKIEVVKQDQIEHVYNEKNVMIKCRQSPFIVQLYRTYRNDKYVYFLMEACMGGD 777
            ...:..|:||:||..:|...|.||:.:||.:|.:. .|.|||:||||:::.||:|.|||||:||:
Zfish   395 DEMKTFAMKILKKRHIVDTRQQEHIRSEKLIMQEA-HSDFIVRLYRTFKDSKYLYMLMEACLGGE 458

  Fly   778 VWTVMSKRQYFDEKTAKFIAGCVVEAFDYLHSHHFIYRDLKPENLMLGTDGYCKLVDFGFAKFVR 842
            :||::..|..||:.|.:|...||||||.||||...||||||||||:|...||.|||||||||.:.
Zfish   459 LWTILRDRGNFDDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIG 523

  Fly   843 QNEKTNTFAGTPEYVAPEIILDRGHDRAVDYWALGILVYELLVGKTPFRGVNQIKIYQQILSGID 907
            ..:||.||.||||||||||||::|||.:.|||:||||:||||.|..||.|.:.:|.|..||.|||
Zfish   524 FGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGID 588

  Fly   908 VIHMPSRIPKSAQHLVRHLCKQLPAERLGYQRKGIADIKRHSWFESLDWQRLKLKQLPSPIKRPL 972
            :|..|.:|.|:|.:|::.||:..|:||||..:.|:.||::|.|||..:|..|:...|..||...:
Zfish   589 MIEFPKKITKNAANLIKKLCRDTPSERLGNLKNGVKDIQKHKWFEGFNWDGLRKGTLMPPIIPNV 653

  Fly   973 KSWTDLQYFGPSGVENDYEPPEELSGWDKDF 1003
            .|.||...|.....:|:..||::.||||.||
Zfish   654 TSSTDTSNFDSFPEDNEDPPPDDNSGWDIDF 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4839	NP_609349.1	Crp	428..577	CDD:223736	51/148 (34%)
		CAP_ED	431..539	CDD:237999	40/107 (37%)
		Crp	544..>650	CDD:223736	38/106 (36%)
		CAP_ED	550..663	CDD:237999	37/113 (33%)
		S_TKc	695..951	CDD:214567	138/258 (53%)
		STKc_cGK	700..957	CDD:270724	139/259 (54%)
prkg1a	XP_005157115.1	DD_cGKI-beta	6..57	CDD:213375	10/43 (23%)
		Crp	114..>264	CDD:223736	52/150 (35%)
		CAP_ED	116..225	CDD:237999	40/109 (37%)
		Crp	228..>332	CDD:223736	37/104 (36%)
		CAP_ED	235..339	CDD:237999	36/104 (35%)
		PTZ00263	355..674	CDD:140289	155/322 (48%)
		STKc_cGK	379..639	CDD:270724	140/260 (54%)
		S_TK_X	634..>677	CDD:214529	12/42 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123183at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100630
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X815
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820