DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4839 and Pnpla7

DIOPT Version :9

Sequence 1:	NP_609349.1	Gene:	CG4839 / 34348	FlyBaseID:	FBgn0032187	Length:	1003	Species:	Drosophila melanogaster
Sequence 2:	NP_653339.2	Gene:	Pnpla7 / 246246	RGDID:	708466	Length:	1349	Species:	Rattus norvegicus

Alignment Length:	550	Identity:	111/550 - (20%)
Similarity:	194/550 - (35%)	Gaps:	132/550 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 PSIEIEDVRDAK-----DTGDGMDSLGERVQPGANAHVDVVDGGGKSKLKVNVNGIIDESVAHDD 205
            |.|.|..|:|.:     ...||.:.:.:.|.||.:.|              ::..|:|....|..
  Rat   203 PDISIYVVQDGRLEVCIQDADGTEVVVKEVLPGDSVH--------------SLLSILDVITGHTA 253

  Fly   206 DYDTPSSNSIATTPVTEGPVKFFIG------------------HTQELSAQQTDDTLSCQSSDAN 252
            .|.|.|:.:...:.|...|...|.|                  ..|.::.....:.|...:...|
  Rat   254 PYKTVSARAAVASTVLWLPAAAFQGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFN 318

  Fly   253 NNS-AAKLTNGVVPQEQPEREM--GKQQALQAPPRAKSSSNVSLNYLAKSQTDSQRRRRVSTMPD 314
            ..| |..|.:......:.:|:|  |.::.|:..||           |::..:..||...||
  Rat   319 PESQAIPLLSVASVAGRAKRQMSYGPEEQLERSPR-----------LSEFNSSDQRSVAVS---- 368

  Fly   315 INIPPAPPLPPELLVPGTPLHLRKKRSMERQQQQKQQEQQQQQEIQQDAT--------------N 365
                 .|.|.....||..|:|  .:....||.|.........||.|:.||              :
  Rat   369 -----GPLLKRSCSVPLPPIH--GEIDELRQAQGSGSNTSAFQESQEGATSDLGMAYNRARILPH 426

  Fly   366 SQDQMAGAEESHKSSDSSTPKTHRVEGGLIYVRPNFPIQSDIEIESIAKDE----GTRNLIRTAI 426
            |::|: |:..:.||..|...:|..|                .......:||    |..:.|..|.
  Rat   427 SEEQL-GSSLASKSKKSVVAETSAV----------------FHYSEKPRDEPGPSGRTDAIFRAA 474

  Fly   427 ERNDFLNNLMDKERKEMVINAMAPASYRKHSLIIREHEEGSEIYVSAEGQYDVIRGGQLVASF-- 489
            .::  |..||..:...::...:|.......:::.::.::...|.....|...|.:  |.:.|.
  Rat   475 TKD--LLTLMKLDDPSLLDGRVAFLHVPAGTIVSKQGDQDVNILFVVSGMLHVYQ--QKIDSLED 535

  Fly   490 ------GPATVFGELAILYNAPRQASIEAATDARVWKIARETFRAIMQISGSREREE------NL 542
                  .|..:.|:||:|...|...:|.|..|.....|::..|..||     |:|.:      :.
  Rat   536 TCLFLTHPGEMVGQLAVLTGEPLMFTIRANRDCSFLSISKAHFYEIM-----RKRPDVVLGVAHT 595

  Fly   543 QFLRSAPFLQEFDQSLLLKVVDLLQRKFYETDSCIVREGELGNEFYIIRCGTV--TIKKLDEQQQ 605
            ...|.:.|:::.|.:|     |.::   .|....|.|:|:..:..||:..|.:  .|:|  :..:
  Rat   596 VVRRMSSFVRQIDFAL-----DWME---VEAGRAIYRQGDKSDCTYIVLSGRLRSVIRK--DDGK 650

  Fly   606 EQIVANRKRGDYFGEQALLNADVRQASVYA 635
            :::.....|||..|...:|....|..:|:|
  Rat   651 KRLAGEYGRGDLVGVVEMLTHQARATTVHA 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4839	NP_609349.1	Crp	428..577	CDD:223736	30/162 (19%)
		CAP_ED	431..539	CDD:237999	23/115 (20%)
		Crp	544..>650	CDD:223736	21/93 (23%)
		CAP_ED	550..663	CDD:237999	20/87 (23%)
		S_TKc	695..951	CDD:214567
		STKc_cGK	700..957	CDD:270724
Pnpla7	NP_653339.2	Crp	164..>306	CDD:223736	22/116 (19%)
		CAP_ED	170..291	CDD:237999	21/101 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..361		6/31 (19%)
		Crp	478..>607	CDD:223736	26/135 (19%)
		CAP_ED	478..588	CDD:237999	24/116 (21%)
		Crp	600..>729	CDD:223736	20/90 (22%)
		CAP_ED	601..709	CDD:237999	20/89 (22%)
		Involved in the binding to lipid droplets. /evidence=ECO:0000250\|UniProtKB:A2AJ88	678..964		1/2 (50%)
		Pat_PNPLA6_PNPLA7	930..1235	CDD:132864
		RssA	935..1221	CDD:224666
		GXGXXG. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	951..956
		GXSXG. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	978..982
		DGA/G. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	1100..1102
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1297..1349
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900