DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4839 and Pnpla7

DIOPT Version :9

Sequence 1:	NP_609349.1	Gene:	CG4839 / 34348	FlyBaseID:	FBgn0032187	Length:	1003	Species:	Drosophila melanogaster
Sequence 2:	XP_036017642.1	Gene:	Pnpla7 / 241274	MGIID:	2385325	Length:	1384	Species:	Mus musculus

Alignment Length:	634	Identity:	124/634 - (19%)
Similarity:	211/634 - (33%)	Gaps:	186/634 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 PSIEIEDVRDAK--------DTGDGMDSLGERVQPGANAHVDVVDGGGKSKLKVNVNGIIDESVA 202
            |.|.|..|:|.:        .|.||.:.:.:.|.||.:.|              ::..|:|....
Mouse   203 PDISIYVVQDGRLEVCIQDAVTQDGTEVVVKEVLPGDSVH--------------SLLSILDVITG 253

  Fly   203 HDDDYDTPSSNSIATTPVTEGPVKFF---------------------------------IGHTQE 234
            |...|.|.|:.:..::.|...|...|                                 :|.|.|
Mouse   254 HTAPYKTVSARAAVSSTVLWLPAAAFQGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTE 318

  Fly   235 LSAQQTDDTLSCQSSDANNNSAAKLTNGVVPQEQPEREMGKQQALQAPPRAKSSSNVSLNYLAKS 299
            |...::........:.....:..:::.|  |:||.||.: :.....:.....|...||...|.:|
Mouse   319 LFNPESQAIPLLSVASVAGRAKRQMSYG--PEEQLERSL-RPSEFSSSDHGSSCVTVSGPLLKRS 380

  Fly   300 QTDSQRRRRVSTMPDINIPPAPPLP------PELLVPGTPLHLRKKRSMERQQQQKQQEQQQQQE 358
                               .:.|||      .||                ||.|.........||
Mouse   381 -------------------CSVPLPSNHGEVDEL----------------RQSQGSGSNTSAFQE 410

  Fly   359 IQQDAT--------------NSQDQMAG--AEESHKSSDSSTPKTHRVEGGLIYVRPNFPIQSDI 407
            ..:.||              :|.:|:..  |.:|.||..:.||      ..:.:...||
Mouse   411 SHEGATSDLGMAYNRARILPHSDEQLGNSLASKSKKSVVAETP------SAIFHYSENF------ 463

  Fly   408 EIESIAKDE----GTRNLIRTAIERNDFLNNLMDKERKEMVINAMAPASYRKHSLIIREHEEGSE 468
                  :||    |..:.|..|..::  |..||..:...::...:|.......:|:.::.::...
Mouse   464 ------RDETGACGKTDAIFRAATKD--LLTLMKLDDPSLLDGRVAFLHVPAGTLVSKQGDQDVN 520

  Fly   469 IYVSAEGQYDVIRGGQLVASF--------GPATVFGELAILYNAPRQASIEAATDARVWKIARET 525
            |.....|...|.:  |.:.|.        .|..:.|:||:|...|...:|.|..|.....|::..
Mouse   521 ILFVVSGMLHVYQ--QKIDSLEDTCLFLTHPGEMVGQLAVLTGEPLMFTIRANRDCSFLSISKAH 583

  Fly   526 FRAIMQISGSREREE------NLQFLRSAPFLQEFDQSLLLKVVDLLQRKFYETDSCIVREGELG 584
            |..||     |:|.:      :....|.:.|:::.|.:|     |.::   .|....|.|:|:..
Mouse   584 FYEIM-----RKRPDVVLGVAHTVVKRMSSFVRQIDFAL-----DWME---VEAGRAIYRQGDKS 635

  Fly   585 NEFYIIRCGTV--TIKKLDEQQQEQIVANRKRGDYFGEQALLNADVRQASVYADAPGTEVLMLDR 647
            :..||:..|.:  .|:|  :..::::.....|||..|....|....|..:|:| ...:|:..|..
Mouse   636 DCTYIVLSGRLRSVIRK--DDGKKRLAGEYGRGDLVGVVETLTHQARATTVHA-VRDSELAKLPA 697

  Fly   648 EAFISYLGTIKQ--------LREK--PSSQRNDTSGRS---STKSLEFD 683
            .|..|......|        |.||  .|.|:...:|..   :|.|.::|
Mouse   698 GALTSIKRRYPQVVTRLIHLLGEKILGSLQQGSATGHQLGFNTASSKWD 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4839	NP_609349.1	Crp	428..577	CDD:223736	31/162 (19%)
		CAP_ED	431..539	CDD:237999	24/115 (21%)
		Crp	544..>650	CDD:223736	24/107 (22%)
		CAP_ED	550..663	CDD:237999	27/122 (22%)
		S_TKc	695..951	CDD:214567
		STKc_cGK	700..957	CDD:270724
Pnpla7	XP_036017642.1	CAP_ED	170..294	CDD:237999	21/104 (20%)
		CAP_ED	484..594	CDD:237999	25/116 (22%)
		CAP_ED	607..715	CDD:237999	26/118 (22%)
		Pat_PNPLA6_PNPLA7	944..1249	CDD:132864
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900