DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4839 and AKT1

DIOPT Version :10

Sequence 1:NP_609349.1 Gene:CG4839 / 34348 FlyBaseID:FBgn0032187 Length:1003 Species:Drosophila melanogaster
Sequence 2:NP_005154.2 Gene:AKT1 / 207 HGNCID:391 Length:480 Species:Homo sapiens


Alignment Length:416 Identity:131/416 - (31%)
Similarity:218/416 - (52%) Gaps:38/416 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   579 REGELGNEFYIIRCGTVTIKKLDEQQQEQIVANRKRGDYFGEQALLNADVRQASVYADAPGTEVL 643
            ||..| |.|.:.:|             :.:...|.|.:.|..:.|....|.:.:.:.:.|.    
Human    48 REAPL-NNFSVAQC-------------QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPE---- 94

  Fly   644 MLDREAFISYLGTIKQ-LREKPSSQRNDTSGRSSTKSLEFDNEYS------QVAISELKKIATLG 701
              :||.:.:.:.|:.. |:::...:.:..||..|..|...:.|.|      :|.::|.:.:..||
Human    95 --EREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLG 157

  Fly   702 CGAFGRVDLVAYNQQA----LALKIIKKIEVVKQDQIEHVYNEKNVMIKCRQSPFIVQLYRTYRN 762
            .|.||:|.||  .::|    .|:||:||..:|.:|::.|...|..|:...|. ||:..|..:::.
Human   158 KGTFGKVILV--KEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRH-PFLTALKYSFQT 219

  Fly   763 DKYVYFLMEACMGGDVWTVMSKRQYFDEKTAKFIAGCVVEAFDYLHSH-HFIYRDLKPENLMLGT 826
            ...:.|:||...||:::..:|:.:.|.|..|:|....:|.|.|||||. :.:|||||.|||||..
Human   220 HDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDK 284

  Fly   827 DGYCKLVDFGFAK-FVRQNEKTNTFAGTPEYVAPEIILDRGHDRAVDYWALGILVYELLVGKTPF 890
            ||:.|:.|||..| .::......||.|||||:|||::.|..:.||||:|.||:::||::.|:.||
Human   285 DGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF 349

  Fly   891 RGVNQIKIYQQILSGIDVIHMPSRIPKSAQHLVRHLCKQLPAERLGYQRKGIADIKRHSWFESLD 955
            ...:..|:::.||  ::.|..|..:...|:.|:..|.|:.|.:|||...:...:|.:|.:|..:.
Human   350 YNQDHEKLFELIL--MEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIV 412

  Fly   956 WQRLKLKQLPSPIKRPLKSWTDLQYF 981
            ||.:..|:|..|.|..:.|.||.:||
Human   413 WQHVYEKKLSPPFKPQVTSETDTRYF 438

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4839NP_609349.1 CAP_ED 431..539 CDD:237999
CAP_ED 550..663 CDD:237999 16/84 (19%)
STKc_cGK 700..957 CDD:270724 96/262 (37%)
AKT1NP_005154.2 PH_PKB 4..111 CDD:269947 15/82 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 113..138 5/24 (21%)
STKc_PKB_alpha 124..479 CDD:270746 113/320 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 450..480
Blue background indicates that the domain is not in the aligned region.

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