DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4839 and Prkg2

DIOPT Version :9

Sequence 1:	NP_609349.1	Gene:	CG4839 / 34348	FlyBaseID:	FBgn0032187	Length:	1003	Species:	Drosophila melanogaster
Sequence 2:	NP_032952.3	Gene:	Prkg2 / 19092	MGIID:	108173	Length:	762	Species:	Mus musculus

Alignment Length:	721	Identity:	291/721 - (40%)
Similarity:	417/721 - (57%)	Gaps:	60/721 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   335 HLRKKRSMERQQQQKQ-------QEQQQQQEIQQDATNSQDQMAGAEESHKSSDSSTPKTHRVEG 392
            ||::.    |:|..||       .|:.|.:.||.:.......:.|......|.|......||...
Mouse    50 HLKEL----REQLAKQTVAIAELTEELQSKCIQLNKLQDVIHVQGGSPLQASPDKVPLDVHRKTS 110

  Fly   393 GLIYVRP-------------------NFPIQSDIEIESIAKDEGTRNLIRTAIERNDFLNNLMDK 438
            ||:.:..                   |.|.:...|...:.||...:.||..|:.:|.||..|..:
Mouse   111 GLVSLHSRRGAKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQ 175

  Fly   439 ERKEMVINAMAPASYRKHSLIIREHEEGSEIYVSAEGQYDVIRGGQLVASFGPATVFGELAILYN 503
            :.|:|| ..|...:|::.|.:|::.|.|:.|:|.|||:.:|.:|.:|::|....|.|||||||||
Mouse   176 QIKDMV-ECMYGRNYQQGSYVIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYN 239

  Fly   504 APRQASIEAATDARVWKIARETFRAIMQISGSREREENLQFLRSAPFLQEFDQSLLLKVVDLLQR 568
            ..|.||::|.|:.:.|.:.||.|:.||:.:.....||...||||...|:...:..|.|::|.|:.
Mouse   240 CTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEEYRNFLRSVSLLKNLPEDKLTKIIDCLEV 304

  Fly   569 KFYETDSCIVREGELGNEFYIIRCGTVTIKKLDE-QQQEQIVANRKRGDYFGEQALLNADVRQAS 632
            ::|:....|:||||.|:.|:|:..|.|.:.:..| ..|.|::...::|:||||:||::.|||.|:
Mouse   305 EYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSAN 369

  Fly   633 VYADAPGTEVLMLDREAFISYLGTIKQLR--------------EKPSSQRNDTSGR-SSTKSLEF 682
            :.|:......|::|||.|...:||..:|:              ||..::|:.:|.: |...|||.
Mouse   370 IIAEENDVACLVIDRETFNQTVGTFDELQKYLEGYVATLNRDDEKRHAKRSMSSWKLSKALSLEM 434

  Fly   683 DNEYSQVA-------ISELKKIATLGCGAFGRVDLVAYNQQ--ALALKIIKKIEVVKQDQIEHVY 738
            .....:||       ...|:.|||||.|.||||:||....:  |.|:|.|:|..:|...|.||||
Mouse   435 IQLKEKVARFSSTSPFQNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVY 499

  Fly   739 NEKNVMIK-CRQSPFIVQLYRTYRNDKYVYFLMEACMGGDVWTVMSKRQYFDEKTAKFIAGCVVE 802
            :||.::.: |  |||||:||||::::||||.|:|||:||::|:::..|..|||.|:||...||.|
Mouse   500 SEKRILEELC--SPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTE 562

  Fly   803 AFDYLHSHHFIYRDLKPENLMLGTDGYCKLVDFGFAKFVRQNEKTNTFAGTPEYVAPEIILDRGH 867
            ||||||....||||||||||:|..|||.|||||||||.:...:||.||.|||||||||:||::||
Mouse   563 AFDYLHRLGIIYRDLKPENLILDADGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGH 627

  Fly   868 DRAVDYWALGILVYELLVGKTPFRGVNQIKIYQQILSGIDVIHMPSRIPKSAQHLVRHLCKQLPA 932
            |.:||:|:|||||||||.|..||.|::|:..|..||.||:.:..|.:|.:..:.|:|.||:|.|.
Mouse   628 DFSVDFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNPT 692

  Fly   933 ERLGYQRKGIADIKRHSWFESLDWQRLKLKQLPSPIKRPLKSWTDLQYFGPSGVENDYEPPEELS 997
            ||||..:.||.|||:|.|....:|:.||.:.||||::|.|....|..||.....|... ||:|:|
Mouse   693 ERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLRRELSGPIDHSYFDKYPPEKGV-PPDEMS 756

  Fly   998 GWDKDF 1003
            ||||||
Mouse   757 GWDKDF 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4839	NP_609349.1	Crp	428..577	CDD:223736	55/148 (37%)
		CAP_ED	431..539	CDD:237999	42/107 (39%)
		Crp	544..>650	CDD:223736	39/106 (37%)
		CAP_ED	550..663	CDD:237999	39/127 (31%)
		S_TKc	695..951	CDD:214567	143/258 (55%)
		STKc_cGK	700..957	CDD:270724	141/259 (54%)
Prkg2	NP_032952.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	118..138		0/19 (0%)
		Crp	162..>285	CDD:223736	50/123 (41%)
		cGMP-binding, high affinity, cAMP-binding, moderate affinity. /evidence=ECO:0000250\|UniProtKB:Q13237	168..283		46/115 (40%)
		CAP_ED	168..273	CDD:237999	42/105 (40%)
		cGMP-binding, high affinity, cAMP-binding, low affinity. /evidence=ECO:0000250\|UniProtKB:Q13237	286..416		41/129 (32%)
		CAP_ED	286..401	CDD:237999	39/114 (34%)
		PTZ00263	417..752	CDD:140289	166/337 (49%)
		STKc_cGK	459..718	CDD:270724	142/260 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	740..762		11/22 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100630
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X815
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.710