DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4839 and Prkacb

DIOPT Version :9

Sequence 1:	NP_609349.1	Gene:	CG4839 / 34348	FlyBaseID:	FBgn0032187	Length:	1003	Species:	Drosophila melanogaster
Sequence 2:	NP_001157672.1	Gene:	Prkacb / 18749	MGIID:	97594	Length:	398	Species:	Mus musculus

Alignment Length:	384	Identity:	134/384 - (34%)
Similarity:	208/384 - (54%)	Gaps:	43/384 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   639 GTEVLMLDREAFISYL------GTIKQLREKPSSQRNDTSGRSSTKSLEFDNEY----------- 686
            ||...:...|.|.|.|      ||.::.|    :...|...|:|..:..:|...
Mouse    14 GTPTALQKLEGFASRLFHRHSRGTAQEHR----AALEDDGLRASEHTASWDKSMKEFLAKAKEDF 74

  Fly   687 ---------SQVAISELKKIATLGCGAFGRVDLVAY--NQQALALKIIKKIEVVKQDQIEHVYNE 740
                     |...:.:.::..|||.|:||||.||.:  .:|..|:||:.|.:|||..||||..||
Mouse    75 LRKWENPPPSNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNE 139

  Fly   741 KNVMIKCRQSPFIVQLYRTYRNDKYVYFLMEACMGGDVWTVMSKRQYFDEKTAKFIAGCVVEAFD 805
            |.: ::..:.||:|:|..:::::..:|.:||...||::::.:.:...|.|..|:|.|..:|..|:
Mouse   140 KRI-LQAVEFPFLVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 203

  Fly   806 YLHSHHFIYRDLKPENLMLGTDGYCKLVDFGFAKFVRQNEKTNTFAGTPEYVAPEIILDRGHDRA 870
            ||||...||||||||||::...||.::.||||||  |...:|.|..|||||:||||||.:|:::|
Mouse   204 YLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK--RVKGRTWTLCGTPEYLAPEIILSKGYNKA 266

  Fly   871 VDYWALGILVYELLVGKTPFRGVNQIKIYQQILSGIDVIHMPSRIPKSAQHLVRHLCKQLPAERL 935
            ||:||||:|:||:..|..||.....|:||::|:||  .:..||......:.|:|:|.:....:|.
Mouse   267 VDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--KVRFPSHFSSDLKDLLRNLLQVDLTKRF 329

  Fly   936 GYQRKGIADIKRHSWFESLDWQRLKLKQLPSPIKRPLKSWTDLQYFGPSGVENDYEPPE 994
            |..:.|::|||.|.||.:.||..:..:::.:|.....:...|...|      :|||..|
Mouse   330 GNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNF------DDYEEEE 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4839	NP_609349.1	Crp	428..577	CDD:223736
		CAP_ED	431..539	CDD:237999
		Crp	544..>650	CDD:223736	3/10 (30%)
		CAP_ED	550..663	CDD:237999	9/29 (31%)
		S_TKc	695..951	CDD:214567	109/257 (42%)
		STKc_cGK	700..957	CDD:270724	111/258 (43%)
Prkacb	NP_001157672.1	PTZ00263	79..398	CDD:140289	121/315 (38%)
Prkacb	NP_001157672.1	STKc_PKA	89..378	CDD:271111	116/299 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910