DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4839 and M110.7

DIOPT Version :9

Sequence 1:	NP_609349.1	Gene:	CG4839 / 34348	FlyBaseID:	FBgn0032187	Length:	1003	Species:	Drosophila melanogaster
Sequence 2:	NP_495734.3	Gene:	M110.7 / 187474	WormBaseID:	WBGene00010915	Length:	1095	Species:	Caenorhabditis elegans

Alignment Length:	857	Identity:	154/857 - (17%)
Similarity:	272/857 - (31%)	Gaps:	278/857 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 YSPIVTPSASEAKLQRLRQQQQPPGSPPAPARWTLHSVAENGSANNGVQERKFRTNKDKLQAQDA 113
            |.|..|.::||..:.  ..::.|...|.:|.|....|..|..:.:      |.|.:.:|:..|..
Worm    45 YFPDTTQNSSEVFID--PPERNPIFYPISPLRHKKRSSKEEMTPD------KKRDSSEKISKQPP 101

  Fly   114 C----PSGGSAINVIRSSSKLKP-----VKERRPTALPTEVPSIEIEDVRDAK-DTGDGMDSLGE 168
            .    |:....:     .|.:||     :|......||| ...::.:||.... |||..:
Worm   102 RELFEPNEQEQV-----PSHIKPEIFFVLKALEGLELPT-TWQLDPKDVETLSIDTGSVV----- 155

  Fly   169 RVQPGANAHVDVVDGGGKSKLKVNVNGIIDESVAHDDDYDTP-----------SSNSIATTPVTE 222
             :.||....|.||...|:..:..||:       ..|..||..           |..||....:.|
Worm   156 -LSPGRANDVIVVVISGELGIFTNVS-------LGDKRYDCNIKTLRSGESYFSQTSIIEILMNE 212

  Fly   223 GPVKFFIGHTQELSAQQTDDTLSCQSSDANNNS--AAKLTNGVVPQEQPEREMGKQQALQAPPRA 285
            .|...:| |.:.|:        ||:.:..:..|  .:.:.|       |::.:...|.:..  |.
Worm   213 KPNNKYI-HLKALT--------SCRVATYHLTSFHTSFIAN-------PQQWIRTIQVVMT--RL 259

  Fly   286 KSSSNVSLN-YLAKSQTDSQRRRRVSTMPDINIPPAPPLPPELLVPGTPLHLRKKRSMERQQQQK 349
            :..:.::.| ||.                               :.|..|:.::|
Worm   260 QQCTLITCNMYLG-------------------------------IGGKCLNAKRK---------- 283

  Fly   350 QQEQQQQQEIQQDATNSQD--QMAGAEESHKSSDSSTPKTHRVEGGLIYVRPNFPIQSDIEIESI 412
                      ..|:...:|  ::..||:.:|..::            |......|.|||...|.:
Worm   284 ----------LPDSGKFKDFNKLTEAEQLNKGVEA------------IAQAMGIPDQSDKLREKV 326

  Fly   413 AKDEGTRNLIRTAIERNDFLNNLMDKERKEMVINAMAPASYRKHSLIIREHEEGSEIYVSAEGQY 477
            .|.|.....:.|  |.|.|        ..:|:.........::..|   ||::
Worm   327 RKYECQAGTVVT--EENSF--------EIDMIFVVFGKLRLKRGDL---EHDD------------ 366

  Fly   478 DVIRGGQLVASFGPATVFGELAILYNAPRQASIEAATDARVWKIARETFRAIM---QISGSRERE 539
               .|..|.....|..:...:.||.|.|...|.:|......:||.|:.:...:   .:...|...
Worm   367 ---TGTSLTFDVYPGDMLPSMQILTNEPAMCSAKALEKTIYFKICRDEYIQFLFAHPVIYLRLAF 428

  Fly   540 ENLQFLRSAPFLQEFDQSLLLKVVDLLQRKFYETDSCIVREGELGNEFYIIRCGTVTIKKLDEQQ 604
            ..|||:  :||.:.||.::....:        ||...:.|:|:..:..:|:..|     :|....
Worm   429 HALQFI--SPFARVFDMAVHWHRI--------ETGQALFRQGDKSDSMHIVMGG-----RLRAVD 478

  Fly   605 QEQIVANRKRGDYFGEQALLNADVRQASVYA---------------------DAPGTEVLMLDRE 648
            ..:|:....|.|..|...:.....|:.:|.|                     ...|.::|.|..:
Worm   479 STKIIEEYGRLDLIGITDMAEKRPRRNTVMAVRFSHIVCIPENLLSFVKIRYPQVGNKLLKLISK 543

  Fly   649 AF-------ISYLGT-----IKQLREKPSSQR-----------NDTSGRSSTKSLE---FDNEYS 687
            .:       :|::.|     ::.:...|:|:|           |..|....|..|.   .:|.:.
Worm   544 CWKAPTPETMSHVETTRNQNLRTIAIVPASRRVPLTEFTCELYNQLSKHVKTLRLSSSVVENYFE 608

  Fly   688 QVAISELKKIATLGCGAFGRVDLVAY------------NQQALALKIIKKIEVV------KQDQI 734
            ...|:   |.|..|...:..|..:||            |.....|::...|.:|      |::|:
Worm   609 SEVIT---KKADYGLMHWLNVQEIAYSLVLYQCDFHKTNWTRRCLRMADAILMVALGTESKEEQV 670

  Fly   735 EHVYNEKNVMIKCRQSPFIVQLYRTYRNDKYVYFLMEACMGGDVWTVMSKRQYFDEKTAKFIAGC 799
                 ....::.|.:        :..|..|.:.||         |.:       |..|....|..
Worm   671 -----LAEALLSCNE--------KGVRQSKELVFL---------WPI-------DTPTPSGTAAW 706

  Fly   800 VVEAFDYLHSHH 811
            :.|:: |...||
Worm   707 IKESY-YSGYHH 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4839	NP_609349.1	Crp	428..577	CDD:223736	28/151 (19%)
		CAP_ED	431..539	CDD:237999	18/110 (16%)
		Crp	544..>650	CDD:223736	22/126 (17%)
		CAP_ED	550..663	CDD:237999	22/145 (15%)
		S_TKc	695..951	CDD:214567	25/135 (19%)
		STKc_cGK	700..957	CDD:270724	23/130 (18%)
M110.7	NP_495734.3	CAP_ED	316..427	CDD:237999	28/138 (20%)
		Crp	325..>432	CDD:223736	23/134 (17%)
		Crp	423..>543	CDD:223736	25/134 (19%)
		CAP_ED	444..538	CDD:237999	15/106 (14%)
		Patatin_and_cPLA2	752..1040	CDD:299702
		RssA	756..1046	CDD:224666
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900