Protein Alignment CG4839 and egl-4

DIOPT Version :10

• Sequence 1: NP_609349.1
• Gene: CG4839 / 34348
• FlyBaseID: FBgn0032187
• Length: 1003
• Species: Drosophila melanogaster
• Sequence 2: NP_001294450.1
• Gene: egl-4 / 176991
• WormBaseID: WBGene00001173
• Length: 783
• Species: Caenorhabditis elegans
• Alignment Length: 744
• Identity: 273/744 - (36%)
• Similarity: 415/744 - (55%)
• Gaps: 72/744 - (9%)

  Fly   297 AKSQTDSQRRRRVSTMPDINIPPAPPLPPELLVPGTPLHLR--KKRSMERQQQQ----------- 348
            |.|:.|:|.|:: .|:.:.:|.....|..|:    |.|...  |.||:..|:.|
 Worm    75 AISRKDAQLRQQ-QTIVEGHIKRISELEGEV----TTLQRECDKLRSVLEQKAQSAASPGGQPPS 134

  Fly   349 -KQQEQQQQQEIQQDATNSQDQMAGAEESHKSSDSSTPKTHRVEGGLIYVRPNFPIQSDIEIESI 412
             ..:..|...::||.|....|   |.:.:.|.:.|:.|             .||. .....::..
 Worm   135 PSPRTDQLGNDLQQKAVLPAD---GVQRAKKIAVSAEP-------------TNFE-NKPATLQHY 182

  Fly   413 AKDEGTRNLIRTAIERNDFLNNLMDKERKEMVINAMAPASYRKHSLIIREHEEGSEIYVSAEGQY 477
            .|..|.:.:||.|:::||||..|. ||:...::|.|.....|....:|:|.|.|..::|.|||:.
 Worm   183 NKTVGAKQMIRDAVQKNDFLKQLA-KEQIIELVNCMYEMRARAGQWVIQEGEPGDRLFVVAEGEL 246

  Fly   478 DVIRGGQLVASFGPATVFGELAILYNAPRQASIEAATDARVWKIARETFRAIMQISGSREREENL 542
            .|.|.|.|:......||.||||||||..|.||::|.||.::|.:.|..|:.|.|..|.....:.:
 Worm   247 QVSREGALLGKMRAGTVMGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQLM 311

  Fly   543 QFLRSAPFLQEFDQSLLLKVVDLLQRKFYETDSCIVREGE---LGNEFYIIRCGTVTI-KKLDEQ 603
            .||......|...:..:.|:.|::.:.:|:....|:|:||   .|:.|::|..|.|.: ::::.:
 Worm   312 NFLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKCLQGDAFFVINSGQVKVTQQIEGE 376

  Fly   604 QQEQIVANRKRGDYFGEQALLNADVRQASVYADAPGTEVLMLDREAFISYLGTIKQL-------- 660
            .:.:.:....:||:|||:|||..:||.|::.|.|||.|||.||||:|...:|.::.|
 Worm   377 TEPREIRVLNQGDFFGERALLGEEVRTANIIAQAPGVEVLTLDRESFGKLIGDLESLKKDYGDKE 441

  Fly   661 ------REKPSSQRNDTSGRSSTKSL-EFDNEYSQVAISELKKIATLGCGAFGRVDLVAYN---Q 715
                  ||.|          |..|.: :|..|::||.:..:|::||||.|.||||:||..|   .
 Worm   442 RLAQVVREPP----------SPVKIVDDFREEFAQVTLKNVKRLATLGVGGFGRVELVCVNGDKA 496

  Fly   716 QALALKIIKKIEVVKQDQIEHVYNEKNVMIKCRQSPFIVQLYRTYRNDKYVYFLMEACMGGDVWT 780
            :..|||.:||..:|...|.||::.|:|:|:: ..:.:||:||:|:|:.|:||.|:|.|:||::||
 Worm   497 KTFALKALKKKHIVDTRQQEHIFAERNIMME-TSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWT 560

  Fly   781 VMSKRQYFDEKTAKFIAGCVVEAFDYLHSHHFIYRDLKPENLMLGTDGYCKLVDFGFAKFVRQNE 845
            .:..|.:||:.||:|...||:|..:|||..:.:||||||||.:|...||.|||||||||.:....
 Worm   561 TLRDRGHFDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGR 625

  Fly   846 KTNTFAGTPEYVAPEIILDRGHDRAVDYWALGILVYELLVGKTPFRGVNQIKIYQQILSGIDVIH 910
            ||.||.||||||:|||||::|||:|.|||||||.:.||::|:.||:..:.:|.|..||.|:|.:.
 Worm   626 KTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALE 690

  Fly   911 MPS-RIPKSAQHLVRHLCKQLPAERLGYQRKGIADIKRHSWFESLDWQRLKLKQLPSPIKRPLKS 974
            :|: ||.|:|..||:.||:..|.||||....|:.||::|.||...||:.|:.:.|..||...:.:
 Worm   691 IPNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWFMGFDWEGLRSRTLKPPILPKVSN 755

  Fly   975 WTDLQYFGPSGVENDYEPPEELSGWDKDF 1003
            ..|:..|.....:||. ||:|.||||:.|
 Worm   756 PADVTNFDNYPPDNDV-PPDEFSGWDEGF 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4839	NP_609349.1	CAP_ED	431..539	CDD:237999	42/107 (39%)
		CAP_ED	550..663	CDD:237999	39/130 (30%)
		STKc_cGK	700..957	CDD:270724	128/260 (49%)
egl-4	NP_001294450.1	CAP_ED	201..314	CDD:237999	42/113 (37%)
		CAP_ED	319..437	CDD:237999	38/117 (32%)
		STKc_cGK	478..739	CDD:270724	129/261 (49%)
		S_TK_X	734..783	CDD:214529	17/49 (35%)