DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4839 and egl-4

DIOPT Version :9

Sequence 1:	NP_609349.1	Gene:	CG4839 / 34348	FlyBaseID:	FBgn0032187	Length:	1003	Species:	Drosophila melanogaster
Sequence 2:	NP_001294450.1	Gene:	egl-4 / 176991	WormBaseID:	WBGene00001173	Length:	783	Species:	Caenorhabditis elegans

Alignment Length:	744	Identity:	273/744 - (36%)
Similarity:	415/744 - (55%)	Gaps:	72/744 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 AKSQTDSQRRRRVSTMPDINIPPAPPLPPELLVPGTPLHLR--KKRSMERQQQQ----------- 348
            |.|:.|:|.|:: .|:.:.:|.....|..|:    |.|...  |.||:..|:.|
Worm    75 AISRKDAQLRQQ-QTIVEGHIKRISELEGEV----TTLQRECDKLRSVLEQKAQSAASPGGQPPS 134

  Fly   349 -KQQEQQQQQEIQQDATNSQDQMAGAEESHKSSDSSTPKTHRVEGGLIYVRPNFPIQSDIEIESI 412
             ..:..|...::||.|....|   |.:.:.|.:.|:.|             .||. .....::..
Worm   135 PSPRTDQLGNDLQQKAVLPAD---GVQRAKKIAVSAEP-------------TNFE-NKPATLQHY 182

  Fly   413 AKDEGTRNLIRTAIERNDFLNNLMDKERKEMVINAMAPASYRKHSLIIREHEEGSEIYVSAEGQY 477
            .|..|.:.:||.|:::||||..|. ||:...::|.|.....|....:|:|.|.|..::|.|||:.
Worm   183 NKTVGAKQMIRDAVQKNDFLKQLA-KEQIIELVNCMYEMRARAGQWVIQEGEPGDRLFVVAEGEL 246

  Fly   478 DVIRGGQLVASFGPATVFGELAILYNAPRQASIEAATDARVWKIARETFRAIMQISGSREREENL 542
            .|.|.|.|:......||.||||||||..|.||::|.||.::|.:.|..|:.|.|..|.....:.:
Worm   247 QVSREGALLGKMRAGTVMGELAILYNCTRTASVQALTDVQLWVLDRSVFQMITQRLGMERHSQLM 311

  Fly   543 QFLRSAPFLQEFDQSLLLKVVDLLQRKFYETDSCIVREGE---LGNEFYIIRCGTVTI-KKLDEQ 603
            .||......|...:..:.|:.|::.:.:|:....|:|:||   .|:.|::|..|.|.: ::::.:
Worm   312 NFLTKVSIFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKCLQGDAFFVINSGQVKVTQQIEGE 376

  Fly   604 QQEQIVANRKRGDYFGEQALLNADVRQASVYADAPGTEVLMLDREAFISYLGTIKQL-------- 660
            .:.:.:....:||:|||:|||..:||.|::.|.|||.|||.||||:|...:|.::.|
Worm   377 TEPREIRVLNQGDFFGERALLGEEVRTANIIAQAPGVEVLTLDRESFGKLIGDLESLKKDYGDKE 441

  Fly   661 ------REKPSSQRNDTSGRSSTKSL-EFDNEYSQVAISELKKIATLGCGAFGRVDLVAYN---Q 715
                  ||.|          |..|.: :|..|::||.:..:|::||||.|.||||:||..|   .
Worm   442 RLAQVVREPP----------SPVKIVDDFREEFAQVTLKNVKRLATLGVGGFGRVELVCVNGDKA 496

  Fly   716 QALALKIIKKIEVVKQDQIEHVYNEKNVMIKCRQSPFIVQLYRTYRNDKYVYFLMEACMGGDVWT 780
            :..|||.:||..:|...|.||::.|:|:|:: ..:.:||:||:|:|:.|:||.|:|.|:||::||
Worm   497 KTFALKALKKKHIVDTRQQEHIFAERNIMME-TSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWT 560

  Fly   781 VMSKRQYFDEKTAKFIAGCVVEAFDYLHSHHFIYRDLKPENLMLGTDGYCKLVDFGFAKFVRQNE 845
            .:..|.:||:.||:|...||:|..:|||..:.:||||||||.:|...||.|||||||||.:....
Worm   561 TLRDRGHFDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLASGR 625

  Fly   846 KTNTFAGTPEYVAPEIILDRGHDRAVDYWALGILVYELLVGKTPFRGVNQIKIYQQILSGIDVIH 910
            ||.||.||||||:|||||::|||:|.|||||||.:.||::|:.||:..:.:|.|..||.|:|.:.
Worm   626 KTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILKGVDALE 690

  Fly   911 MPS-RIPKSAQHLVRHLCKQLPAERLGYQRKGIADIKRHSWFESLDWQRLKLKQLPSPIKRPLKS 974
            :|: ||.|:|..||:.||:..|.||||....|:.||::|.||...||:.|:.:.|..||...:.:
Worm   691 IPNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWFMGFDWEGLRSRTLKPPILPKVSN 755

  Fly   975 WTDLQYFGPSGVENDYEPPEELSGWDKDF 1003
            ..|:..|.....:||. ||:|.||||:.|
Worm   756 PADVTNFDNYPPDNDV-PPDEFSGWDEGF 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4839	NP_609349.1	Crp	428..577	CDD:223736	50/148 (34%)
		CAP_ED	431..539	CDD:237999	42/107 (39%)
		Crp	544..>650	CDD:223736	37/109 (34%)
		CAP_ED	550..663	CDD:237999	39/130 (30%)
		S_TKc	695..951	CDD:214567	128/259 (49%)
		STKc_cGK	700..957	CDD:270724	128/260 (49%)
egl-4	NP_001294450.1	Crp	195..>316	CDD:223736	47/121 (39%)
		CAP_ED	201..314	CDD:237999	42/113 (37%)
		Crp	313..>427	CDD:223736	38/113 (34%)
		CAP_ED	319..437	CDD:237999	38/117 (32%)
		PTZ00263	461..779	CDD:140289	147/319 (46%)
		STKc_cGK	478..739	CDD:270724	129/261 (49%)
		S_TK_X	734..783	CDD:214529	17/49 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1041
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123183at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100630
Panther	1	1.100	-	-	O	PTHR24353
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X815
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.870