Protein Alignment CG4839 and Pkg21D

DIOPT Version :10

• Sequence 1: NP_609349.1
• Gene: CG4839 / 34348
• FlyBaseID: FBgn0032187
• Length: 1003
• Species: Drosophila melanogaster
• Sequence 2: XP_061512039.1
• Gene: Pkg21D / 1275446
• VectorBaseID: AGAMI1_000949
• Length: 1270
• Species: Anopheles gambiae
• Alignment Length: 1155
• Identity: 367/1155 - (31%)
• Similarity: 550/1155 - (47%)
• Gaps: 223/1155 - (19%)

  Fly     9 HNRSKNKFTPAEDENTDTILNTQDSNVQIGKY--IRREEKPLYSPIVTPSAS-------EAKLQR 64
            |:.|..|..|    |...:...|.:|   |.|  :.......||   ||:..       |..||:
Mosquito   179 HDASVRKSHP----NRALVPTAQTAN---GDYEILHTAHSKRYS---TPTIGTGYAFHPEFVLQK 233

  Fly    65 L---------RQQQQPPGSPPAPARWTLHSVAENGSANNGVQERKFRTNKDKLQAQD---ACPSG 117
            |         ..|.|.|.....|.|        .|:|....::|...:.....:..:   ||.|.
Mosquito   234 LGPIGDETGGAAQIQSPSPQSEPVR--------GGAAKVVFKQRSCTSYPGLAEGSEPFGACFSN 290

  Fly   118 GSAINVIRSSSKLKPVKERRPT---ALPT-----------------------EVPSIEIEDVRDA 156
            .|::..:.|.     |..|:.|   ||||                       ..|:|.:.|....
Mosquito   291 ASSVEEVESG-----VARRQDTEIGALPTLGSFEDLERRQSVSSPPLPQQQQHQPAITVNDTGGT 350

  Fly   157 KDT-----------------------------------GDGMDSLGERVQPGANAHVDVVDGGGK 186
            .||                                   ..|.|.|...:..|..||       .:
Mosquito   351 LDTTGHCRGVLIESNSNSAGKVSSACAIPARKGRQLFVDSGSDQLSVSLDTGREAH-------RR 408

  Fly   187 SKLKVNVNGIIDESVAHDDDYDTPSSNSIATTPVTEGPVKFFIGHTQELSAQQTDDTLSCQSSDA 251
            |:...:..|.:...::.::  ..||..|:..:||.  |.||      :.||::............
Mosquito   409 SEAAHHQPGAVASCISAEN--SPPSPPSLLLSPVI--PSKF------DCSAKEYLIQSGILGPMG 463

  Fly   252 NNNS-AAKLTNGVVPQEQPEREMGKQQALQAPPRAKSSSNVSLNYLAKSQTDSQRRRRVSTMPDI 315
            |.:| ..:.|:.:||.            :..|.:.:...| |:.:..|..|:.:|:........:
Mosquito   464 NGSSLLMRKTSKIVPN------------IDTPVKERIRKN-SVKFWGKVLTEDRRKSLTGHCDSL 515

  Fly   316 NIPPAPPLPPELLVPGT-PLHLRK-----KRSMERQQQQ----KQQEQQQQQEIQQDATNSQDQM 370
            .     .....:.:.|| |..|.:     :|.:..:..:    :::..:.:..:||.|.||.:|.
Mosquito   516 Q-----SYGSSMTISGTEPNSLEEELVGLRRLLRARDDEIDKLRREIDKLKSVLQQKAINSLEQT 575

  Fly   371 ---AGAEESHKSSDSSTPK---THRVEGGLI------YVRPNFPI-------------------- 403
               :|.:....:|.:.||.   .|..||.|:      |.....|:
Mosquito   576 SIPSGQQRLTLTSPAGTPSHKGQHVAEGELLSSIQANYAMAGQPLSELFGISGNSFKLHQMKSVK 640

  Fly   404 -----------------------QSDIEIESIAKDEGTRNLIRTAIERNDFLNNLMDKERKEMVI 445
                                   .|||:|....||...:.||:.||..|||..|:...:.:| ::
Mosquito   641 GITLQAMKKQGVSGESCDLMGSQSSDIKIPKYKKDFSAKQLIKDAIMENDFFKNIDSLQIRE-IV 704

  Fly   446 NAMAPASYRKHSLIIREHEEGSEIYVSAEGQYDVIRGGQLVASFGPATVFGELAILYNAPRQASI 510
            ::|....:||...:|.|.|.||.:||||.|:::||:..:::...||...|||||||||..|.|||
Mosquito   705 DSMYSREFRKGEYVIHEGEAGSHLYVSAAGEFEVIKDSKVLGVMGPGRAFGELAILYNCTRTASI 769

  Fly   511 EAATDARVWKIARETFRAIMQISGSREREENLQFLRSAPFLQEFDQSLLLKVVDLLQRKFYETDS 575
            ....|:|||.:.|..|:.||..:|.:..|||:.||:|.|.|:.....:|.|:.|:|:.:||...:
Mosquito   770 RVLCDSRVWVLDRRVFQQIMMRTGMQRIEENVNFLKSVPLLKHLSNDVLTKIADVLEVEFYPAGA 834

  Fly   576 CIVREGELGNEFYIIRCGTVTI-KKLDEQQQEQIVANRKRGDYFGEQALLNADVRQASVYADAPG 639
            .|:|:|..|:.|::|..|||.: ::|..:..|:.:....||:|||||||:..|.|.|::.|.:||
Mosquito   835 FIIRQGAAGDTFFLISQGTVKVTQRLPGRSVEEEIRILVRGEYFGEQALIREDKRTANIIAMSPG 899

  Fly   640 TEVLMLDREAFISYLGTIKQLREKPSSQ-------RNDTSGRSSTKSLEFDNEYSQVAISELKKI 697
            .|.|.||||:|..::|.:.:|:||....       ||..:...|..|.:  .|...|.:::|:.:
Mosquito   900 VECLTLDRESFTKHIGDLCELQEKNYGDEERVLAFRNLENTHPSLGSCQ--PELMDVNLTDLEVV 962

  Fly   698 ATLGCGAFGRVDLVAYNQ----QALALKIIKKIEVVKQDQIEHVYNEKNVMIKCRQSPFIVQLYR 758
            .|||.|.||||:||...:    :..|||.:||..:|...|.||:|:|:.:|:.| |||||.:|||
Mosquito   963 GTLGVGGFGRVELVKLERNGDTKVYALKCMKKRHIVDTRQQEHMYSERKIMLAC-QSPFICRLYR 1026

  Fly   759 TYRNDKYVYFLMEACMGGDVWTVMSKRQYFDEKTAKFIAGCVVEAFDYLHSHHFIYRDLKPENLM 823
            ||::.|:||.|:||||||:|||::..|..|::.|||||..||::|||:||:...:|||||||||:
Mosquito  1027 TYKDAKFVYMLLEACMGGEVWTILRDRVTFEDSTAKFIVACVLQAFDFLHARGIVYRDLKPENLL 1091

  Fly   824 LGTDGYCKLVDFGFAKFVRQNEKTNTFAGTPEYVAPEIILDRGHDRAVDYWALGILVYELLVGKT 888
            |...||.|||||||:||:..:.||.||.||||||||||||::||||:|||||||||::|||.|..
Mosquito  1092 LDARGYAKLVDFGFSKFIGYSSKTWTFCGTPEYVAPEIILNKGHDRSVDYWALGILIHELLTGIP 1156

  Fly   889 PFRGVNQIKIYQQILSGIDVIHMPSRIPKSAQHLVRHLCKQLPAERLGYQRKGIADIKRHSWFES 953
            ||...:.:|.|..||.|||:::.|..:.::|..|::.||:.:|:|||||||.|:.|||:|.||:.
Mosquito  1157 PFTAADPMKTYNIILKGIDMVNFPKHMSRAAVSLIKRLCRDVPSERLGYQRGGVQDIKKHKWFQG 1221

  Fly   954 LDWQRLKLKQLPSPIKRPLKSWTDLQYFGPSGVENDYEPPEELSGWDKDF 1003
            .||..|....|.||::..|....|:..|.....:.|. ||:||||||.||
Mosquito  1222 FDWDGLIALTLKSPLQPNLLGPLDMSNFDIFPKDLDI-PPDELSGWDADF 1270

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4839	NP_609349.1	CAP_ED	431..539	CDD:237999	42/107 (39%)
		CAP_ED	550..663	CDD:237999	42/113 (37%)
		STKc_cGK	700..957	CDD:270724	143/260 (55%)
Pkg21D	XP_061512039.1	None