DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4839 and PNPLA6

DIOPT Version :9

Sequence 1:	NP_609349.1	Gene:	CG4839 / 34348	FlyBaseID:	FBgn0032187	Length:	1003	Species:	Drosophila melanogaster
Sequence 2:	NP_001159583.1	Gene:	PNPLA6 / 10908	HGNCID:	16268	Length:	1375	Species:	Homo sapiens

Alignment Length:	920	Identity:	178/920 - (19%)
Similarity:	303/920 - (32%)	Gaps:	304/920 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 LQRLRQQQQPPGSPPAP-------------ARWTLHSVAENGSANNGVQERKFRTNKDKLQAQDA 113
            ::|||..:.|  :|..|             .|..:..|::  |.::.|......|::.:::.:
Human    80 VRRLRVPKTP--APDGPRYRFRKRDKVLFYGRKIMRKVSQ--STSSLVDTSVSATSRPRMRKK-- 138

  Fly   114 CPSGGSAINVIRSSSKLKPVKERRPTALPTEVPSIEIE-DVRDAKDTGDGMDS------------ 165
                   :.::..:.|:..:::..||....|.|...:| |:.:    ||..:|
Human   139 -------LKMLNIAKKILRIQKETPTLQRKEPPPAVLEADLTE----GDLANSHLPSEVLYMLKN 192

  Fly   166 ---LG----------------ERV----------QPGANAHVDVVDG----------GGKSKLKV 191
               ||                :|:          ||.|:.:| |.||          |.:..:|.
Human   193 VRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQPDASIYV-VQDGLLELCLPGPDGKECVVKE 256

  Fly   192 NVNG--------IIDESVAHDDDYDTPSSNSIATTPVTEGPVKFF------------------IG 230
            .|.|        |:|....|.....|.|:.:...:.|...||:.|                  :.
Human   257 VVPGDSVNSLLSILDVITGHQHPQRTVSARAARDSTVLRLPVEAFSAVFTKYPESLVRVVQIIMV 321

  Fly   231 HTQELSAQQTDDTLSCQSSDANNNSAAKLTNGVVPQE-QPEREMGKQQALQAP--PRAKSSSNVS 292
            ..|.::.....:.|.             |||.:...| ||.|      ...:|  |...|....|
Human   322 RLQRVTFLALHNYLG-------------LTNELFSHEIQPLR------LFPSPGLPTRTSPVRGS 367

  Fly   293 LNYLAKSQTDSQRRRRVSTMPDINIPPAP-----PL-PPELLVPGTPLHLRKKRSM--------- 342
            ...::.|.|| :.|......||....|.|     |: |..|..|..|| |.:..||
Human   368 KRMVSTSATD-EPRETPGRPPDPTGAPLPGPTGDPVKPTSLETPSAPL-LSRCVSMPGDISGLQG 430

  Fly   343 -ERQQQQKQQEQQQ-QQEIQQDATNS-------------QDQMAGA-EESHKSSDSSTPKTHRVE 391
             .|.......|:.: ...:|::|:..             ::|.||| |.|:...:|:|
Human   431 GPRSDFDMAYERGRISVSLQEEASGGSLAAPARTPTQEPREQPAGACEYSYCEDESAT------- 488

  Fly   392 GGLIYVRPNFPIQ--SDIEIESIAKDEGTRNLIRTAIERNDFLNNLMDKERKEMVINAMAPASYR 454
            ||.    |..|.|  ....|...||.| ...|:|  ||....||
Human   489 GGC----PFGPYQGRQTSSIFEAAKQE-LAKLMR--IEDPSLLN--------------------- 525

  Fly   455 KHSLIIREHEEGSEIYVSAEGQYDV----------------IRGGQLVASF--GPATVFGELAIL 501
              |.::..|.:...| ::.:|..||                |...:.|..|  .|..:.|:||:|
Human   526 --SRVLLHHAKAGTI-IARQGDQDVSLHFVLWGCLHVYQRMIDKAEDVCLFVAQPGELVGQLAVL 587

  Fly   502 YNAPRQASIEAATDARVWKIARETFRAIMQISGSRE-REENLQFLRSAPFLQEFDQSLLLKVVDL 565
            ...|...::.|..|....:|::..|..||:...|.. ...:....|.:||:::.|.::....|
Human   588 TGEPLIFTLRAQRDCTFLRISKSDFYEIMRAQPSVVLSAAHTVAARMSPFVRQMDFAIDWTAV-- 650

  Fly   566 LQRKFYETDSCIVREGELGNEFYIIRCGTVTIKKLDEQQQEQIVANRKRGDYFGEQALLNADVRQ 630
                  |....:.|:|:..:..||:..|.:.........::::|....|||..|....|....|.
Human   651 ------EAGRALYRQGDRSDCTYIVLNGRLRSVIQRGSGKKELVGEYGRGDLIGVVEALTRQPRA 709

  Fly   631 ASVYADAPGTEVLMLDREAFISY--------------------LGTIKQLREK-PSSQRNDTSGR 674
            .:|:| ...||:..|. |..:.:                    ||.::||:.. |:.     ||.
Human   710 TTVHA-VRDTELAKLP-EGTLGHIKRRYPQVVTRLIHLLSQKILGNLQQLQGPFPAG-----SGL 767

  Fly   675 SSTKSLEFDNEYSQVAISELKKIATLGCGAFGRVDLVAYN------QQALALKIIKKIEVVKQ-- 731
            ......|..|..|.:|...:..:.       ..|.:||:.      .||:...::...::::.
Human   768 GVPPHSELTNPASNLATVAILPVC-------AEVPMVAFTLELQHALQAIGPTLLLNSDIIRARL 825

  Fly   732 -----DQIEHVYNEKNVMIKCRQSPFIVQLYRTYRNDKYVYFLMEACMGGDVWTVMSKRQYFDEK 791
                 |.|:          :.|.|.::.|....:|   .|.:..:|.:  ..|||...||
Human   826 GASALDSIQ----------EFRLSGWLAQQEDAHR---IVLYQTDASL--TPWTVRCLRQ----- 870

  Fly   792 TAKFIAGCVV 801
                 |.|::
Human   871 -----ADCIL 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4839	NP_609349.1	Crp	428..577	CDD:223736	30/167 (18%)
		CAP_ED	431..539	CDD:237999	24/126 (19%)
		Crp	544..>650	CDD:223736	24/105 (23%)
		CAP_ED	550..663	CDD:237999	26/132 (20%)
		S_TKc	695..951	CDD:214567	20/120 (17%)
		STKc_cGK	700..957	CDD:270724	20/115 (17%)
PNPLA6	NP_001159583.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		CAP_ED	195..316	CDD:237999	23/121 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	352..436		22/85 (26%)
		Atrophin-1	<354..502	CDD:331285	38/160 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..472		2/22 (9%)
		CAP_ED	512..622	CDD:237999	27/135 (20%)
		CAP_ED	635..743	CDD:237999	23/117 (20%)
		Pat_PNPLA6_PNPLA7	964..1269	CDD:132864
		GXGXXG. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	985..990
		GXSXG. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	1012..1016
		DGA/G. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	1134..1136
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1306..1375
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900