DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4839 and prkg1

DIOPT Version :9

Sequence 1:	NP_609349.1	Gene:	CG4839 / 34348	FlyBaseID:	FBgn0032187	Length:	1003	Species:	Drosophila melanogaster
Sequence 2:	XP_002935474.2	Gene:	prkg1 / 100494278	XenbaseID:	XB-GENE-966465	Length:	685	Species:	Xenopus tropicalis

Alignment Length:	684	Identity:	269/684 - (39%)
Similarity:	403/684 - (58%)	Gaps:	25/684 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   336 LRKKRSMERQQ----QQKQQEQQQQQEIQQDATNSQDQ-----MAGAEESHKSSDSSTPKTHRVE 391
            |::|....||:    .:.:.|..|:.|:.|...|..|:     ....::.|| .:.:|....|.:
Frog    11 LQEKIEELRQRDALIDELELELDQKDELIQRLQNELDKYRSVIKPATQQVHK-QNPTTLGEQRTK 74

  Fly   392 GGLIYVRPN-FPIQ--SDIEIESIAKDEGTRNLIRTAIERNDFLNNLMDKERKEMVINAMAPASY 453
            ...|...|. ..||  |.:.:....|...::.||:.||..|||:.||...:.:| :::.|.|..|
Frog    75 RQAISAEPTAIDIQELSHVTLPFYPKSPQSKELIKEAILDNDFMKNLEISQIQE-IVDCMYPVEY 138

  Fly   454 RKHSLIIREHEEGSEIYVSAEGQYDVIRGGQLVASFGPATVFGELAILYNAPRQASIEAATDARV 518
            .|.|.||:|.:.||.:||..:|:.:|.:....:.:.||..||||||||||..|.|:::..|:.::
Frog   139 GKDSCIIKEGDVGSLVYVMEDGKVEVTKESVKLCTMGPGKVFGELAILYNCTRTATVKTLTNVKL 203

  Fly   519 WKIARETFRAIMQISGSREREENLQFLRSAPFLQEFDQSLLLKVVDLLQRKFYETDSCIVREGEL 583
            |.|.|:.|:.||..:|..:..|.::||:|.|..|...:.::.|:.|:|:...||:...|:|:|..
Frog   204 WAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEIVSKLADVLEETHYESGDYIIRQGAR 268

  Fly   584 GNEFYIIRCGTVTIKKLDEQQQEQI-VANRKRGDYFGEQALLNADVRQASVYADAPGTEVLMLDR 647
            |:.|:||..|.|.:.:.|...::.| :....:||:|||:||...|||.|:|.| |.....|::||
Frog   269 GDTFFIISKGKVNVTREDSPGEDPIFLRTLGKGDWFGEKALQGEDVRTANVIA-AEAVTCLVIDR 332

  Fly   648 EAFISYLGTIKQLREKPSSQRNDTSGRSSTKSLEFDNEYSQVAISELKKIATLGCGAFGRVDLVA 712
            ::|...:|.:..:..| :.:..:...:...::..|.|    :.:::...|.|||.|.||||:||.
Frog   333 DSFKHLIGGLDDVSNK-AYEDAEAKAKYEAEAAFFGN----LKLADFNIIDTLGVGGFGRVELVQ 392

  Fly   713 YNQ---QALALKIIKKIEVVKQDQIEHVYNEKNVMIKCRQSPFIVQLYRTYRNDKYVYFLMEACM 774
            ...   :..|:||:||..:|...|.||:.:||.:| :...|.|||:||||:::.||:|.|||||:
Frog   393 LKSDECKTFAMKILKKRHIVDTRQQEHIRSEKQIM-QSAHSDFIVRLYRTFKDSKYLYMLMEACL 456

  Fly   775 GGDVWTVMSKRQYFDEKTAKFIAGCVVEAFDYLHSHHFIYRDLKPENLMLGTDGYCKLVDFGFAK 839
            ||::||::..|..||:.|.:|...||||||.||||...||||||||||:|...||.|||||||||
Frog   457 GGELWTILRDRGSFDDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAK 521

  Fly   840 FVRQNEKTNTFAGTPEYVAPEIILDRGHDRAVDYWALGILVYELLVGKTPFRGVNQIKIYQQILS 904
            .:...:||.||.||||||||||||::|||.:.|||:||||:||||.|..||.|.:.:|.|..||.
Frog   522 KIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILR 586

  Fly   905 GIDVIHMPSRIPKSAQHLVRHLCKQLPAERLGYQRKGIADIKRHSWFESLDWQRLKLKQLPSPIK 969
            |||:|..|.:|.|:|.:|::.||:..|:||||..:.|:.||::|.|||..:|:.|:...|..||.
Frog   587 GIDMIEFPKKITKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPII 651

  Fly   970 RPLKSWTDLQYFGPSGVENDYEPPEELSGWDKDF 1003
            ..:.|.||...|.....:|:..||::.||||.||
Frog   652 PSVASPTDTSNFDSFPEDNEDPPPDDNSGWDIDF 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4839	NP_609349.1	Crp	428..577	CDD:223736	53/148 (36%)
		CAP_ED	431..539	CDD:237999	40/107 (37%)
		Crp	544..>650	CDD:223736	38/106 (36%)
		CAP_ED	550..663	CDD:237999	36/113 (32%)
		S_TKc	695..951	CDD:214567	138/258 (53%)
		STKc_cGK	700..957	CDD:270724	139/259 (54%)
prkg1	XP_002935474.2	DD_cGKI-beta	4..55	CDD:213375	10/43 (23%)
		CAP_ED	117..226	CDD:237999	40/109 (37%)
		CAP_ED	236..340	CDD:237999	35/104 (34%)
		STKc_cGK	380..640	CDD:270724	140/260 (54%)
		S_TK_X	635..>678	CDD:214529	12/42 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123183at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X815
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920