DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4839 and prkg2

DIOPT Version :9

Sequence 1:	NP_609349.1	Gene:	CG4839 / 34348	FlyBaseID:	FBgn0032187	Length:	1003	Species:	Drosophila melanogaster
Sequence 2:	XP_021331649.1	Gene:	prkg2 / 100125912	ZFINID:	ZDB-GENE-060531-80	Length:	769	Species:	Danio rerio

Alignment Length:	762	Identity:	298/762 - (39%)
Similarity:	432/762 - (56%)	Gaps:	101/762 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   323 LPPELL---VPGTPLHLRKK----RSMERQ----QQQKQQEQQQQQEIQ-------------QDA 363
            |.|::|   |.....||:||    .:.|.|    ::|..|::|...||.             |||
Zfish    28 LVPQVLRVRVEELETHLKKKDEDLNAKELQIKHLEEQLAQQKQTLSEISDTLRSKCLQLNKLQDA 92

  Fly   364 TNSQDQM------------------------------AG--AEESHKSSDSSTPKTHRVEGGLIY 396
            ..||.::                              ||  ||.|.::.|||         |:
Zfish    93 LKSQGELGLLPSPLKEKVSQGLTGLLRETLNRRKGAKAGVSAEPSSRTYDSS---------GI-- 146

  Fly   397 VRPNFPIQSDIEIESIAKDEGTRNLIRTAIERNDFLNNLMDKERKEMVINAMAPASYRKHSLIIR 461
              |.|..:|    ..:.|::..:.|:..|:.:|.:|..|..::.|:|| ..|...:|::...:|:
Zfish   147 --PKFYFES----ARVWKEQSVKKLLTDALNKNQYLRRLEVQQVKDMV-ECMYERTYQQGEYVIK 204

  Fly   462 EHEEGSEIYVSAEGQYDVIRGGQLVASFGPATVFGELAILYNAPRQASIEAATDARVWKIARETF 526
            :.|.|:.::|.|:|:.||.:..:|:.|....|.|||||||||..|.||::||::.:.|.:.||.|
Zfish   205 QGEPGNHLFVLADGKLDVYQHNKLLTSIAVWTTFGELAILYNCTRTASVKAASNVKTWALDREVF 269

  Fly   527 RAIMQISGSREREENLQFLRSAPFLQEFDQSLLLKVVDLLQRKFYETDSCIVREGELGNEFYIIR 591
            ..||:::.....|:...||||...|.......|.|:||.|:.::|.....|:||||.||.||||.
Zfish   270 HNIMRMTAEARHEQYRNFLRSVSLLASLPGDKLTKIVDCLEVEYYNKGDYIIREGEEGNTFYIIA 334

  Fly   592 CGTVTIKKLDEQQQE-QIVANRKRGDYFGEQALLNADVRQASVYADAPGTEVLMLDREAFISYLG 655
            .|.:.:.:..:..:| ||:....:||||||:||::.|||.|::.|:..|.|.|::|||.|...:|
Zfish   335 NGKIKVTQSTQDHEEPQIINTLGKGDYFGEKALISDDVRSANIIAEEDGVECLVIDRETFSQTVG 399

  Fly   656 TIKQLRE----------KPSSQRNDTSGRSST-----------KSLEFDNEY-SQVAISELKKIA 698
            |..:|::          :...:||.....|.|           :..|.::.: |.:..:.|:.||
Zfish   400 TFDELKKYLQSYVDSLARDDKKRNAKRSGSCTPPNTPVSHDMIELKERESSFASTIPFTCLEAIA 464

  Fly   699 TLGCGAFGRVDLVAYNQQ--ALALKIIKKIEVVKQDQIEHVYNEKNVMIKCRQSPFIVQLYRTYR 761
            |||.|.||||:||....:  ..|||.|||..:|...|.||:|:|:.:::: ...||||::||||:
Zfish   465 TLGVGGFGRVELVKLKNENVTFALKCIKKRHIVDNRQEEHIYSERRILLE-TNCPFIVKMYRTYK 528

  Fly   762 NDKYVYFLMEACMGGDVWTVMSKRQYFDEKTAKFIAGCVVEAFDYLHSHHFIYRDLKPENLMLGT 826
            ::||||.|:|||:||::|:::..|..|:|.||||..|||.|||||||::..||||||||||||.|
Zfish   529 DNKYVYMLLEACLGGEIWSLLRDRGSFEEYTAKFCVGCVTEAFDYLHNNGIIYRDLKPENLMLDT 593

  Fly   827 DGYCKLVDFGFAKFVRQNEKTNTFAGTPEYVAPEIILDRGHDRAVDYWALGILVYELLVGKTPFR 891
            |||.|||||||||.::..::|.||.||||||||||||::||..:||:|:||||::|||.|..||.
Zfish   594 DGYVKLVDFGFAKKLKCGQRTWTFCGTPEYVAPEIILNKGHGLSVDFWSLGILIFELLTGSPPFT 658

  Fly   892 GVNQIKIYQQILSGIDVIHMPSRIPKSAQHLVRHLCKQLPAERLGYQRKGIADIKRHSWFESLDW 956
            |.:|:.||..||.||:.:..|.:|.|....|:|.||:|.|:||||..:.||.|||:|.||....|
Zfish   659 GSDQMIIYTFILKGIEKMDFPKKITKRPGDLIRKLCRQNPSERLGNLKNGITDIKKHRWFTGFSW 723

  Fly   957 QRLKLKQLPSPIKRPLKSWTDLQYFGPSGVENDYEPPEELSGWDKDF 1003
            ..||.:.|.||:||.:|..||..||.....|.:. ||:|:||||.||
Zfish   724 SGLKARNLISPLKREVKGPTDHSYFDSYPPEEEI-PPDEMSGWDTDF 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4839	NP_609349.1	Crp	428..577	CDD:223736	51/148 (34%)
		CAP_ED	431..539	CDD:237999	38/107 (36%)
		Crp	544..>650	CDD:223736	45/106 (42%)
		CAP_ED	550..663	CDD:237999	45/123 (37%)
		S_TKc	695..951	CDD:214567	142/257 (55%)
		STKc_cGK	700..957	CDD:270724	141/258 (55%)
prkg2	XP_021331649.1	CAP_ED	176..284	CDD:237999	39/108 (36%)
		CAP_ED	293..408	CDD:237999	45/114 (39%)
		STKc_cGK	466..725	CDD:270724	142/259 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123183at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100630
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X815
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.720