Protein Alignment KCNT2 and SLO2

DIOPT Version :10

• Sequence 1: XP_006711357.1
• Gene: KCNT2 / 343450
• HGNCID: 18866
• Length: 1142
• Species: Homo sapiens
• Sequence 2: NP_001097259.2
• Gene: SLO2 / 5740325
• FlyBaseID: FBgn0261698
• Length: 1878
• Species: Drosophila melanogaster
• Alignment Length: 1544
• Identity: 643/1544 - (41%)
• Similarity: 845/1544 - (54%)
• Gaps: 457/1544 - (29%)

Human    30 DDRVQVEFYMNENTFKERLKLFFIKNQRSSLRIRLFNFSLKLLSCLLYIIRVLLE-NPS------ 87
            |:||:||:|:|||||||||:|:||||||||||||:.:..||||||:||||||:|: ||:
  Fly    92 DERVRVEYYVNENTFKERLQLYFIKNQRSSLRIRIADLFLKLLSCVLYIIRVILDKNPTFITCYG 156

Human    88 --QGNE---------------------WSHIFWVNRSLPLWGLQVSVALISLFETILLGYLSYKG 129
              .||:                     |..|.||||...||.||:.:|::||.::::|.||.|||
  Fly   157 CEVGNKTEFIISAKLTEEEFQENPIINWDAILWVNRPTVLWVLQLLLAMVSLTQSLVLTYLGYKG 221

Human   130 NIWEQILRIPFILEIINAVPFIISIFWPSLRNLFVPVFLNCWLAKHALENMINDLHRAIQRTQSA 194
            |||:|||...||||::..:||.::|..|.|||||:|:||||||||.:||||.||||||:|::|||
  Fly   222 NIWQQILSFHFILELVTTIPFALTIVHPPLRNLFIPIFLNCWLAKRSLENMFNDLHRAMQKSQSA 286

Human   195 MFNQVLILISTLLCLIFTCICGIQHLERIG-KKLNLFDSLYFCIVTFSTVGFGDVTPETWSSKLF 258
            :..|:.||.:|||||:||.:|||||.:|.| :.||||.|.|:.:|||||||:||..|:.|.|:|:
  Fly   287 LSQQLTILSATLLCLVFTSVCGIQHFQRAGHRHLNLFQSTYYVVVTFSTVGYGDFVPDIWPSQLY 351

Human   259 VVAMICVALVVLPIQFEQLAYLWMERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNEFYA 323
            :|.||||||:|||.||||||:.||||||.||:||.||||:|||||:|.::|..|.:|||||||||
  Fly   352 MVIMICVALIVLPTQFEQLAFTWMERQKLGGSYSSHRAQSEKHVVVCSTTLHADTIMDFLNEFYA 416

Human   324 HPRLQDYYVVILCPTEMDVQVRRVLQIPMWSQRVIYLQGSALKDQDLLRAKMDDAEACFILSSRC 388
            ||.|||:|||:|.|.|:|..:|.:||:|:|:|||||:|||.|||.||.||:|::|||||||::|.
  Fly   417 HPLLQDFYVVLLSPMELDTTMRMILQVPIWAQRVIYIQGSCLKDGDLARARMNEAEACFILAARN 481

Human   389 EVDRTSSDHQTILRAWAVKDFAPNCPLYVQILKPENKFHIKFADHVVCEEEFKYAMLALNCICPA 453
            ..|:|::|..||||:|||||||||.|.||||.:||:|.|:|||:|||||:|||||:||.||.||.
  Fly   482 YADKTAADEHTILRSWAVKDFAPNVPQYVQIFRPEHKLHVKFAEHVVCEDEFKYALLANNCTCPG 546

Human   454 TSTLITLLVHTSRGQEGQQSPEQWQKMYGRCSGNEVYHIVLEESTFFAEYEGKSFTYASFHAHKK 518
            .|||:|||:|||||||||||||:|.::||:|||||:|||||.:|.||.|||||||||||||:|:|
  Fly   547 ASTLVTLLLHTSRGQEGQQSPEEWHRLYGKCSGNEIYHIVLGDSRFFGEYEGKSFTYASFHSHRK 611

Human   519 FGVCLIGVRRED-----NKNILLNPGPRYIMNSTDICFYINITKEENSAF---KNQD-------- 567
            :||.|:|||..:     .:.||||||||:||...|.|:|::|||||||||   :||.
  Fly   612 YGVALVGVRPAELPEFYEETILLNPGPRHIMKKDDTCYYMSITKEENSAFVVNQNQTSDPTAAAK 676

Human   568 ----------------------------------QQRKSNVSRSFY------------------- 579
                                              |...:.:|.:|.
  Fly   677 EGSGTGGGGGASSSASHHHTAATANPTTTITTTVQATTTTISTTFTSSTLLSASTTTATINATST 741

Human   580 ---------------------------------------------HGPSRLPVHSIIASM----- 594
                                                         |.|.:.|.....||:
  Fly   742 AAAAPPPVPSVCVRVPHSPSYDSGGGTTGTTHLQPYPYPQSYPQPHPPMQTPDSGEFASLFVPSE 806

Human   595 -GTVAI------DLQDTSC--RSASGPTLSLP----TEGSKEI---------------------- 624
             .|..|      :|:||:.  .:|:..|.:||    |.||..:
  Fly   807 NPTAVIISDSRQNLKDTTVTQTAATITTTTLPPPPQTMGSPSMAGGSGGCGGGGLGLGSAHSMGT 871

Human   625 --------------------------------------RRPSIAPVLEVADTSSI---------- 641
                                                  |||||.||.::..:||.
  Fly   872 SLSITPATLTTTGNHLDVPFANNPNLLSPDVLNQRRGSRRPSILPVPDMFTSSSFSIAGNDDGEE 936

Human   642 -------------------------------QTCDLLSDQSEDE--------------------- 654
                                           :|..|:...|||.
  Fly   937 GDESDDEIDDEMPWRSPSEKIACLGGHFPQSRTYSLIMSSSEDSYQRGCSFCSATASASAAAVAV 1001

Human   655 -----------------------------TTPDEE------------------------------ 660
                                         ..|.||
  Fly  1002 AVAAAPAPAPAPAYPSDSAGESGTNADSAAMPSEEYLPQLRRRVMKKSYSCDSECRSVPGMGMGM 1066

Human   661 --------------------------------------------------------MSSNLE--- 666
                                                                    .||::|
  Fly  1067 AMGVGLGGGTLARLAARRRQLQRCSSCSCSTATTTTTPAVAATTAMAAGSGATAFTSSSSVETRR 1131

Human   667 ------------YAKGYPPYSPYIGSSPTFCHLLHEKVPFCCLRLDKSCQHNYYEDAKAYGFKNK 719
                        ..||:||.||:||.|||.|:||.||.|.|||:|.:.|:|..|.:||.|.::||
  Fly  1132 PVRPVWVYDYSCIVKGFPPVSPFIGVSPTLCYLLKEKKPLCCLQLAQVCEHCSYRNAKEYQWQNK 1196

Human   720 LIIVAAETAGNGLYNFIVPLRAYYRPKKELNPIVLLLDNPPDMHFLDAICWFPMVYYMVGSIDNL 784
            .||:||:.|.||:||||:||||::|.|..||||:|||:..||:.||||:.:||:||:|:||||.|
  Fly  1197 TIILAADYASNGIYNFIIPLRAHFRSKTSLNPIILLLERRPDVAFLDALSYFPLVYWMLGSIDCL 1261

Human   785 DDLLRCGVTFAANMVVVDKESTMSAEEDYMADAKTIVNVQTLFRLFSSLSIITELTHPANMRFMQ 849
            |||||.|:|.|.::|||:||.:.|||||.::|..|||.||.:|:.|.|:..||||:..:||||||
  Fly  1262 DDLLRAGITLAESVVVVNKELSNSAEEDSLSDCNTIVAVQNMFKFFPSIKSITELSQSSNMRFMQ 1326

Human   850 FRAKDCYSLALSKLEKKERERGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMISITRLLL 914
            |||.|.|:|.|||:||:|:||||::::|||||||||.|||.|||||||||:|||||:|:..||||
  Fly  1327 FRAHDKYALHLSKMEKREKERGSHISYMFRLPFAAGAVFSASMLDTLLYQAFVKDYVITFVRLLL 1391

Human   915 GLDTTPGSGFLCSMKITADDLWIRTYARLYQKLCSSTGDVPIGIYRTESQKLTTSESRKIASQSQ 979
            |:|..||||||.||:||.||:|||||.||||||||:|.::|||||||:.    ||.    |..|.
  Fly  1392 GIDQAPGSGFLTSMRITKDDMWIRTYGRLYQKLCSTTCEIPIGIYRTQD----TSN----ADTSH 1448

Human   980 ISIS-VEEW------------------------EDTKDSKE--QGHHRSNHRNSTSSDQSDHPL- 1016
            :|.| ||.|                        :.||||.|  :|.......::|....|..|.
  Fly  1449 VSNSPVERWGPFSAFSRHCVRLRPSYDEETGTPDSTKDSTEMLRGVTYRPPGSATGGASSFRPQP 1513

Human  1017 LRRKSMQWARRLS-RKGPKHSGKTAEKITQQRLNLYRRSERQELAELVKNRMKHLGLSTVGYDEM 1080
            .|::|:......| |||..:|...|:   :.|.|..::.||.|:|.||::||:.|.|.|:.||::
  Fly  1514 QRQRSVNCLGGCSERKGSSYSINLAD---EARDNHAQQIERAEIANLVRSRMESLNLPTIDYDDV 1575

Human  1081 NDHQSTLSYILINPSPDTRIELNDVVYLIRPDPLAYLPNSE--PSRRNS 1127
            ::.::.|||::||||.|.::|..|::||:||.|.:.....|  .|||.|
  Fly  1576 SEKRNHLSYVIINPSCDLKLEEGDLIYLVRPSPFSAQKTFERHNSRRKS 1624

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNT2	XP_006711357.1	Ion_trans	63..270	CDD:459842	122/237 (51%)
		Ion_trans_2	206..272	CDD:462301	41/66 (62%)
		BK_channel_a	432..526	CDD:460947	69/93 (74%)
SLO2	NP_001097259.2	Ion_trans_2	<319..363	CDD:462301	26/43 (60%)
		BK_channel_a	525..619	CDD:460947	69/93 (74%)