Protein Alignment KCNT2 and slo-2

DIOPT Version :10

• Sequence 1: XP_006711357.1
• Gene: KCNT2 / 343450
• HGNCID: 18866
• Length: 1142
• Species: Homo sapiens
• Sequence 2: NP_001257146.1
• Gene: slo-2 / 181332
• WormBaseID: WBGene00004831
• Length: 1143
• Species: Caenorhabditis elegans
• Alignment Length: 1121
• Identity: 486/1121 - (43%)
• Similarity: 685/1121 - (61%)
• Gaps: 148/1121 - (13%)

Human    38 YMNENTFKERLKLFFIKNQRSSLRIRLFNFSLKLLSCLLYIIRVLLENPSQGNE----------- 91
            |..:...|.:|:.:||:|...|.|||..|..:|||:|:||.|||:.:..|..::
 Worm    79 YGEKKNIKHKLQQWFIENPSISARIRSCNVLIKLLTCILYCIRVVNDERSYPDDFPFSEEEAGKQ 143

Human    92 ----WSHIFWVNRSLPLWGLQVSVALISLFETILLGYLSYKGNIWEQILRIPFILEIINAVPFII 152
                :.::.||:....:|.||...|.||:..|||:.||||.|::...::.|.|:||:|.:.||||
 Worm   144 DVTLYKYLLWVDFDFKIWFLQTMFACISMVYTILVFYLSYSGSVVRLLINIHFLLELITSFPFII 208

Human   153 SIFWPSLRNLFVPVFLNCWLAKHALENMINDLHRAIQRTQSAMFNQVLILISTLLCLIFTCICGI 217
            |||.|||..|:|||||||||||.||:.|:|||:|....:.||:|.|:|:|.|.|.|||||.:|.|
 Worm   209 SIFIPSLTYLYVPVFLNCWLAKGALQAMMNDLNRKSFISSSALFRQLLLLFSVLACLIFTGMCSI 273

Human   218 QHLERI-GKKLNLFDSLYFCIVTFSTVGFGDVTPETWSSKLFVVAMICVALVVLPIQFEQLAYLW 281
            :||:|. ||:::||.|.||.:|||||||:||..|:.|:|:|.||.:|||||.::|.|.::|...|
 Worm   274 EHLQRARGKRIDLFTSFYFVMVTFSTVGYGDWYPDYWASQLCVVILICVALGLIPKQLDELGQTW 338

Human   282 MERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRR 346
            .||||||.::|.... .|.|||:.:::|:::.:.|||.||||||..|...:|:|.|.|:|.|.|.
 Worm   339 SERQKSGTDFSSWNG-VESHVVVTITTLEVEFIRDFLEEFYAHPENQRIQIVLLSPAELDNQTRM 402

Human   347 VLQIPMWSQRVIYLQGSALKDQDLLRAKMDDAEACFILSSRCEVDRTSSDHQTILRAWAVKDFAP 411
            :|:||:|:.||.|::||:|:|:||.||.:..::||||||:|....:.::|..||||:||:|||||
 Worm   403 LLKIPLWNNRVHYVRGSSLRDEDLERANVATSKACFILSARHVNRKVATDEHTILRSWAIKDFAP 467

Human   412 NCPLYVQILKPENKFHIKFADHVVCEEEFKYAMLALNCICPATSTLITLLVHTSRGQEGQQSPEQ 476
            |...||||.:.|.|.||:.|:.::||:|||||:||.|||||..||.||||:|||||:|||:|.|.
 Worm   468 NVKQYVQIFRAETKMHIEHAEVLICEDEFKYALLANNCICPGISTFITLLMHTSRGEEGQKSTEP 532

Human   477 WQKMYGRCSGNEVYHIVLEESTFFAEYEGKSFTYASFHAHKKFGVCLIGVRRE-DNKNILLNPGP 540
            |.|:||..||||:|.|.:::|.||.||.||||:..||||||::|:.||.|..: |...:.||||.
 Worm   533 WHKVYGFHSGNEMYQIKVQDSKFFCEYVGKSFSSTSFHAHKEYGIGLIAVSPDGDTSRMKLNPGS 597

Human   541 RYIMNSTDICFYINITKEEN-SAFKN--QDQQRKSNVSRSFYHGPSRLPVHSIIASMGTVAIDLQ 602
            .:|:..||..:|:.:|.||: :.|:.  :.||:::||:             |.||::||||:|:.
 Worm   598 SHIIQPTDTVYYMGLTNEESLTDFRKGIRSQQKRANVA-------------STIANIGTVAVDVP 649

Human   603 DTSCRSASGPTLSLPTEGSKE-----------------IRRPSIAPVLE-VADTSSIQTCDLLSD 649
                ||.....:....:..||                 .||||||.|.| ..|:||
 Worm   650 ----RSDKTELVGRKKKKRKEKAADEIHLIEVGEHVQSSRRPSIAMVTEGKIDSSS--------- 701

Human   650 QSEDETTPDEEMSSNLEY--AKGYPPYSPYIGSSPTFCHLLHEKVPFCCLRLDKSCQHNYYEDAK 712
            .|:.|...|:.....:::  .:.||....|||:|.|.||::.|:...|||:||:.|.|.....|.
 Worm   702 DSDQEEICDKCRGPCIQHKLQRTYPQVRTYIGTSNTVCHMMKERRSLCCLKLDEKCAHKSATSAH 766

Human   713 AYGFKNKLIIVAAETAGNGLYNFIVPLRAYYRPKKELNPIVLLL-----DNPPDMHFLDAICWFP 772
            .|.::|:.||:||:...:|:||.::||||||||..:|:||::||     |:..|. |||||.:||
 Worm   767 EYQWRNRPIILAADRTSSGMYNLVIPLRAYYRPVHDLHPIIILLELEEQDSLNDA-FLDAISYFP 830

Human   773 MVYYMVGSIDNLDDLLRCGVTFAANMVVVDKESTMSAEEDYMADAKTIVNVQTLFRLFSSLSIIT 837
            .||:|.|.:.|||.|||.||:.|.::||| ||:.:.||| :.||..||:.||.:.|:|..|.:||
 Worm   831 DVYWMKGKVGNLDCLLRAGVSSAEHVVVV-KETAVMAEE-HTADCNTIITVQKIHRMFPRLRMIT 893

Human   838 ELTHPANMRFMQFRAKDCYSLALSKLEKKERERGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFV 902
            ||||..||||:||...:.||||.|:.|||||:|||::.||||||||.|.|||.:|||.||||:.:
 Worm   894 ELTHATNMRFVQFNPHNAYSLAQSRFEKKERKRGSHMPFMFRLPFAQGGVFSANMLDRLLYQAII 958

Human   903 KDYMISITRLLLGLDTTPGSGFLCSMKITADDLWIRTYARLYQKLCSSTGDVPIGIYRTESQKLT 967
            |.:::.:.|||||:|.....|:|.|..||:||||||.|.|||||||||..|:||||:||  :|:.
 Worm   959 KPFVVDLVRLLLGIDQHSDGGYLTSFVITSDDLWIRNYGRLYQKLCSSVADIPIGIFRT--KKMD 1021

Human   968 TSESRKIASQSQISISVEEWEDTKD--SKEQGHHRSNHRNSTSSDQSDHPLLRRKSMQWARRLSR 1030
            |.           ::|::..|..||  :.|.|.::         |..||
 Worm  1022 TK-----------TVSLDLQEQCKDFENTEMGRNK---------DMYDH---------------- 1050

Human  1031 KGPKHSGKTAEKITQQRLNLYRRSERQELAELVKNRMKHLGL-STVGYDEMNDHQSTLSYILINP 1094
                                            |||||:.|.: .|....|.:|.:|.:||::|||
 Worm  1051 --------------------------------VKNRMRLLNIKDTHTLLEGSDEKSQISYVIINP 1083

Human  1095 SPDTRIELNDVVYLIR 1110
            :.|..:|..|:||:||
 Worm  1084 AQDLELESGDIVYVIR 1099

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNT2	XP_006711357.1	Ion_trans	63..270	CDD:459842	107/222 (48%)
		Ion_trans_2	206..272	CDD:462301	38/66 (58%)
		BK_channel_a	432..526	CDD:460947	58/93 (62%)
slo-2	NP_001257146.1	Ion_trans	112..320	CDD:459842	99/207 (48%)
		Ion_trans_2	<285..327	CDD:462301	25/41 (61%)
		BK_channel_a	490..582	CDD:460947	58/91 (64%)