DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FCRL6 and unc-40

DIOPT Version :9

Sequence 1:	XP_005245185.1	Gene:	FCRL6 / 343413	HGNCID:	31910	Length:	444	Species:	Homo sapiens
Sequence 2:	NP_491664.1	Gene:	unc-40 / 172233	WormBaseID:	WBGene00006776	Length:	1415	Species:	Caenorhabditis elegans

Alignment Length:	441	Identity:	92/441 - (20%)
Similarity:	156/441 - (35%)	Gaps:	95/441 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    32 LQAWPNPVFEGDALTLRCQ-GWKNTPLSQVKFYRD-----GKFLHFSKENQTLSMGAATVQSRGQ 90
            |||....:.:|......|. ..|.|| :.|..:.|     |...|....:.||.:.:...:..|.
Worm   152 LQAIDRTLAKGQPTAFHCLINSKPTP-TAVWLHNDEPIVNGGEYHILPVSNTLEISSTQSRHEGT 215

Human    91 YSC---------SGQVMYIPQTFTQTSETAMVQVQELFPPPVLSAIPSPEPREGSLVTLRC---- 142
            |.|         |.|...:..| |:|....:|    ....|.|..:     .:|....|.|
Worm   216 YRCTVEGAGKRRSSQTARLTVT-TETVSNELV----FITTPRLQVV-----EQGDEFLLECLVAS 270

Human   143 --QTKLHPLRSALRLLFSFHKDGHTLQDRGPHPELCIPGAKEGDSGLYWCEVAPEGGQVQKQSPQ 205
              :.::..|:.:.:::.    ||..::..|. ..:.:..|...|:|||.|..:.....:.:   .
Worm   271 LIRPQVRWLKDSRQIIV----DGVRIRRVGV-SSILVSRASIEDTGLYTCRASNNDDSIDR---A 327

Human   206 LEVRVQAP---VSRPVLTLHHGPADPAVGDMVQLLCEAQRGSPPILYSFYLD-EKIVGNH---SA 263
            :.|.|:||   .:||...:....||      |:|.|......|....::|.: |.|:|:.   ..
Worm   328 VSVEVRAPPRITTRPTTKVAVETAD------VELECGTAAARPEARVNWYKNGEAIIGSEYFVIE 386

Human   264 PCGGTTSLLFPVKSEQDAGNYSCEAENSVSRERSEPKKL--SLKGSQVLFTPASNWLVPWLPASL 326
            |  ....:|..|:::|  ..|.|.|||.|..|::..:.|  :...|.|    |::..||...::.
Worm   387 P--NRLRILGVVRADQ--AIYQCIAENDVGSEQASAQLLVDAPDSSSV----AASSGVPMTSSAP 443

Human   327 LGLMVIAAALLVYVRSWRKAGPLPSQIPPTAPGGEQCPLYANVHHQKGKDEGVVYSVVHRTSKRS 391
            |||...::........|.         ||....|       |:         :.|.:.::.:...
Worm   444 LGLRSTSSGSRFINVEWD---------PPVQRNG-------NI---------MRYHIFYKDNLID 483

Human   392 EARSAEFTVGRKDSSIICAEVRCLQPSEVSSTEVNMRSRTLQEPLSDCEEV 442
            ..|..       :||...|.:..||||.:....|...:.......||..:|
Worm   484 RERMI-------NSSSTSATLTSLQPSTMYLIRVTAENEAGMGKFSDSLKV 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FCRL6	XP_005245185.1	Ig2_FcgammaR_like	29..108	CDD:143230	21/90 (23%)
		Ig_2	122..210	CDD:290606	16/93 (17%)
		IG_like	133..208	CDD:214653	13/80 (16%)
		Ig_3	216..290	CDD:290638	19/77 (25%)
unc-40	NP_491664.1	I-set	42..130	CDD:254352
		Ig	43..142	CDD:299845
		I-set	149..236	CDD:254352	19/84 (23%)
		Ig	158..237	CDD:299845	16/79 (20%)
		IG_like	251..332	CDD:214653	16/93 (17%)
		IGc2	258..320	CDD:197706	13/66 (20%)
		I-set	336..422	CDD:254352	23/95 (24%)
		Ig	352..422	CDD:299845	20/79 (25%)
		FN3	441..529	CDD:238020	21/119 (18%)
		FN3	536..627	CDD:238020
		FN3	635..727	CDD:238020
		FN3	738..816	CDD:214495
		FN3	852..927	CDD:214495
		FN3	946..1038	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910