DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FCRL6 and si:dkey-23a13.11

DIOPT Version :9

Sequence 1:	XP_005245185.1	Gene:	FCRL6 / 343413	HGNCID:	31910	Length:	444	Species:	Homo sapiens
Sequence 2:	XP_021333780.1	Gene:	si:dkey-23a13.11 / 100006263	ZFINID:	ZDB-GENE-160113-14	Length:	1089	Species:	Danio rerio

Alignment Length:	409	Identity:	91/409 - (22%)
Similarity:	137/409 - (33%)	Gaps:	142/409 - (34%)

- Green bases have known domain annotations that are detailed below.

Human    37 NPVFEGDALTLRCQGWKNTPLSQVKFY--RDGKFLHFSKE---NQTLSMGAATVQSRGQYSCSGQ 96
            ||||.|:.:.|.|.  ..|..|..:::  :|...||.|..   |:.:....|....:|||.|.|:
Zfish   229 NPVFTGETVNLTCV--ITTYYSIWRYFWDKDDGVLHLSHRHSVNRDILTIRAAESDQGQYWCWGE 291

Human    97 VMYIPQTFTQTSETAMVQVQELFPPPVLSAIPSPEPREGSLVTLRC---------QTKLHPLRSA 152
            : |.....||:| ||:..:.:..|...::..|......|....|:|         ..:.:..|:.
Zfish   292 I-YGRSVSTQSS-TAVYLIVKASPRSTVTVTPDSAVFTGETFNLKCVIESDHSDWTYEWYADRNR 354

Human   153 LRLLFSFHKDGHTLQDRGPHPELCIPGAKEGDSGLYWCEVAPEGGQVQKQSPQLEVRVQAPVSRP 217
            ::|    ..|||...:|   ..|.|.||.|.|.|.|||:...:|..|..|...:.:.|:....:|
Zfish   355 VKL----QSDGHYTVNR---DTLTIRGAAESDQGQYWCKGFIDGRSVSTQPTSVYLTVKDLKPKP 412

Human   218 VLTLHHGPADPAV-GDMV--------------------------------------------QLL 237
              .|...||.||: |:.|                                            |..
Zfish   413 --ELRSDPAGPALTGNTVTLTCNTDLSTGWDFYWYKNTQESEIKTTRTNSYSMKIDSLSDGGQYW 475

Human   238 CEAQRGSPPILYSFYLDEKIVGNHSAP---------------------C----GGTTSLLFPVKS 277
            |.|.||. |:.|:.|.||..:....:|                     |    ||.|...:..:.
Zfish   476 CRAGRGE-PVYYTQYSDELTLSVTESPKAVAIIQPDERVFRGETVTLRCDIKWGGNTEWTYRWEI 539

Human   278 EQ----------------------------------DAGNYSCEAE-NSVSRERSEPKKLSLKGS 307
            ||                                  ..|||||..: |:...:||:|..|::...
Zfish   540 EQTDHYNKYYNQYNQHKNNVSRCSAQELKISLVEVFHRGNYSCTGQMNTQISQRSDPVALTVYSD 604

Human   308 Q----VLFTPASNWLVPWL 322
            :    |..:|.     |||
Zfish   605 EAQAAVQVSPQ-----PWL 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FCRL6	XP_005245185.1	Ig2_FcgammaR_like	29..108	CDD:143230	23/75 (31%)
		Ig_2	122..210	CDD:290606	23/96 (24%)
		IG_like	133..208	CDD:214653	22/83 (27%)
		Ig_3	216..290	CDD:290638	30/178 (17%)
si:dkey-23a13.11	XP_021333780.1	Ig_3	41..115	CDD:316449
		IGc2	234..288	CDD:197706	14/55 (25%)
		Ig_3	316..386	CDD:316449	19/76 (25%)
		IG_like	425..497	CDD:214653	12/72 (17%)
		Ig_2	509..601	CDD:316418	16/91 (18%)
		Ig_3	610..677	CDD:316449	5/14 (36%)
		Ig	785..>847	CDD:325142
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9806
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11481
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010