DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG44153 and ADGRB3

DIOPT Version :9

Sequence 1:	NP_001097136.2	Gene:	CG44153 / 34341	FlyBaseID:	FBgn0265002	Length:	1946	Species:	Drosophila melanogaster
Sequence 2:	NP_001695.2	Gene:	ADGRB3 / 577	HGNCID:	945	Length:	1522	Species:	Homo sapiens

Alignment Length:	1235	Identity:	225/1235 - (18%)
Similarity:	373/1235 - (30%)	Gaps:	431/1235 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 FPHRFATPIECVWIIDASDMPPQGQANVSIVVYLTQLYVLSGLKFTEYMYYSDDF---KV----- 152
            ||..|.   .|.|.::..|     ....||.:..:: ..||...|:...|..|.|   |:
Human    48 FPKNFT---NCTWTLENPD-----PTKYSIYLKFSK-KDLSCSNFSLLAYQFDHFSHEKIKDLLR 103

  Fly   153 PAHRVFTLTEDDVTQVTWVKFHSQYLEIRFTMAT-LDGTHLRALDRLLDVYGFNITYEVQNEVKT 216
            ..|.:..|. :......::::...:::||....| ..|...:..:   |...| ..:.|.|:|..
Human   104 KNHSIMQLC-NSKNAFVFLQYDKNFIQIRRVFPTNFPGLQKKGEE---DQKSF-FEFLVLNKVSP 163

  Fly   217 TQ--CNTLQCRFLGDCYASEDYSSYGCSCFPGFSGSDCGHGPLCKDLHTNVCQNGGTC-KHIGDA 278
            :|  |:.| |.:|..|..||:..:..|    |...:.|                  || :|:|:.
Human   164 SQFGCHVL-CTWLESCLKSENGRTESC----GIMYTKC------------------TCPQHLGEW 205

  Fly   279 AITCHCPKGFKGTRCEIPEINETTQGCTSNSSSIECHQACDFDNFGRSISPPGQSYSASKGNRNA 343
            .|.   .:........:..:||.|:||.  :..::..|.|
Human   206 GID---DQSLILLNNVVLPLNEQTEGCL--TQELQTTQVC------------------------- 240

  Fly   344 ARSGKTRYEVTMRLGANLTGYYRHADREQLSGVMERQLGRVLRNFNITKISDLELISNSTDRLDI 408
                            |||...:...:|:
Human   241 ----------------NLTREAKRPPKEE------------------------------------ 253

  Fly   409 TFHFFGVKGD----SQRIR------------DAITRMVERGRIGNFTLVANFHHFDENPPLGLLE 457
                ||:.||    |||.|            ||...|.:.|
Human   254 ----FGMMGDHTIKSQRPRSVHEKRVPQEQADAAKFMAQTG------------------------ 290

  Fly   458 LTVNQPQSGVREASEF-IISCTAQGSSRMQFQWFKDGAVVNASKSTRE--------------IWT 507
                  :|||.|.|:: ..|.|....|:::.:........:.|...||              :|.
Human   291 ------ESGVEEWSQWSTCSVTCGQGSQVRTRTCVSPYGTHCSGPLRESRVCNNTALCPVHGVWE 349

  Fly   508 TVLPPETKDVYTAILGVTKASRIDEGVYSCKVTDWGVEQCRSLHIHIKSPPRLRVDP-------- 564
            . ..|.:...:|...|....:|      ||....:|...|.....|.| |..:.:.|
Human   350 E-WSPWSLCSFTCGRGQRTRTR------SCTPPQYGGRPCEGPETHHK-PCNIALCPVDGQWQEW 406

  Fly   565 -----ASVTLQRGDSLRVR-----------CLSPGNDDIKRYAQLGYSWTRNGVLFQ-------S 606
                 .|||...|...|.|           |..|..:..:.|   ....|.||...|       |
Human   407 SSWSQCSVTCSNGTQQRSRQCTAAAHGGSECRGPWAESRECY---NPECTANGQWNQWGHWSGCS 468

  Fly   607 DAATAMWEDLYP--DGSILKINNIQKSAEYA--CLVSNSVRPVSRSVYINVIERNAVHVCPAEST 667
            .:....||....  .|:::.....:.:.|..  |.......|              ..:||.:..
Human   469 KSCDGGWERRIRTCQGAVITGQQCEGTGEEVRRCNEQRCPAP--------------YEICPEDYL 519

  Fly   668 YGVHWPTSAPGSPIITDCPRGFEGHLKRICEQRDTGNSTWLLPDFSGCVRDELLLIYNRFLALSA 732
            ..:.|..:..|......||....|...|.|.....|.:.|..|.|:.|:.:|...:.:......|
Human   520 MSMVWKRTPAGDLAFNQCPLNATGTTSRRCSLSLHGVAFWEQPSFARCISNEYRHLQHSIKEHLA 584

  Fly   733 GFQQ----TNSSNILKACFEFTLQRRHSFLPGEASFLIDMLHEL-DTYLQLK------GTQLERE 786
            ..|:    ...|.:.|...:.|  :|.:|..|:....:::|..: ||:.:..      |.|
Human   585 KGQRMLAGDGMSQVTKTLLDLT--QRKNFYAGDLLMSVEILRNVTDTFKRASYIPASDGVQ---- 643

  Fly   787 MAAEIILRILDKVMQNAQSLNSQQQIK----KLQQLTQS----AALNRETIAASQLAT-STSGSS 842
            ...:|:..:||:  :|.:.....|||.    :|.|:.:.    ..:.......|.|.| :...|.
Human   644 NFFQIVSNLLDE--ENKEKWEDAQQIYPGSIELMQVIEDFIHIVGMGMMDFQNSYLMTGNVVASI 706

  Fly   843 QPLPGDSSTRGDDGSGSGVTAGEMSAAPAGSLQATRAGGAGGGPGGASSILT------------V 895
            |.||                                          |:|:||            |
Human   707 QKLP------------------------------------------AASVLTDINFPMKGRKGMV 729

  Fly   896 DEDTLSLDRLNSLRIYMTSVKTLPFNLRIYGEDLFSDQLYMDIGLSSRLLHIMANSTIFA-SVIS 959
            |....|.||:                  :..:.:|:.       :||:.|.   .|::|. ..:.
Human   730 DWARNSEDRV------------------VIPKSIFTP-------VSSKELD---ESSVFVLGAVL 766

  Fly   960 YKNLKSFLPK-TYYTRGSDPRDSDYVLASRIIQTWLFQSNRSNDNFREPLDLPFEAGHVEIIFQH 1023
            ||||...||. ..||          |:.|:||...:....::.|:|     |..|..|:
Human   767 YKNLDLILPTLRNYT----------VINSKIIVVTIRPEPKTTDSF-----LEIELAHL------ 810

  Fly  1024 ESVPKKGDWVAVC--GHDYKASFD-STWRSDLCITKHLMANITRCICPLSGTYVVMLTKRQPNAT 1085
                ..|.....|  ..|.|.:.. .||.:..|.|....|:.|:|:|....|:.::  .:||...
Human   811 ----ANGTLNPYCVLWDDSKTNESLGTWSTQGCKTVLTDASHTKCLCDRLSTFAIL--AQQPREI 869

  Fly  1086 PHNAPRRP--IFVIASCACCLLQCGSALLIL----VPIWCNRKCAVTFLKMQFCVSTSSVMLIYL 1144
            ...:...|  ..::.|...||     ||:.|    ..:|...:...:.:.:.||:|..|..::.|
Human   870 IMESSGTPSVTLIVGSGLSCL-----ALITLAVVYAALWRYIRSERSIILINFCLSIISSNILIL 929

  Fly  1145 LG---------------FMKMLPVSWHGIISSSLASLLLLGISTLIAIALAIHTELMPKKYLQIG 1194
            :|               |:       |....:|...:|.....:.:|:...|.|.|:.|::|.:|
Human   930 VGQTQTHNKSICTTTTAFL-------HFFFLASFCWVLTEAWQSYMAVTGKIRTRLIRKRFLCLG 987

Fly 1195 1194
Human 988 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG44153	NP_001097136.2	EGF_CA	<264..294	CDD:238011	5/30 (17%)
		IG_like	467..554	CDD:214653	18/101 (18%)
		Ig	474..551	CDD:143165	15/90 (17%)
		IG_like	564..653	CDD:214653	21/123 (17%)
		Ig	572..642	CDD:299845	16/91 (18%)
		HRM	661..718	CDD:280888	14/56 (25%)
ADGRB3	NP_001695.2	RSN1_7TM	98..>175	CDD:330792	15/82 (18%)
		TSP1	296..343	CDD:214559	8/46 (17%)
		TSP1	348..398	CDD:214559	12/57 (21%)
		TSP1	403..452	CDD:214559	9/51 (18%)
		TSP1	458..508	CDD:214559	7/49 (14%)
		HormR	510..576	CDD:214468	16/79 (20%)
		GAIN	594..794	CDD:318649	54/287 (19%)
		GPS	816..867	CDD:197639	13/52 (25%)
		7tmB2_BAI3	872..1164	CDD:320655	25/128 (20%)
		TM helix 1	876..901	CDD:320655	7/29 (24%)
		TM helix 2	911..933	CDD:320655	6/21 (29%)
		TM helix 3	942..970	CDD:320655	4/34 (12%)
		TM helix 4	980..1000	CDD:320655	3/8 (38%)
		TM helix 5	1018..1047	CDD:320655
		TM helix 6	1094..1121	CDD:320655
		TM helix 7	1126..1151	CDD:320655
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000