DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG44153 and tutl

DIOPT Version :9

Sequence 1:	NP_001097136.2	Gene:	CG44153 / 34341	FlyBaseID:	FBgn0265002	Length:	1946	Species:	Drosophila melanogaster
Sequence 2:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster

Alignment Length:	1141	Identity:	218/1141 - (19%)
Similarity:	350/1141 - (30%)	Gaps:	434/1141 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   467 VREASEFIISCTAQGSSRMQFQWFKDGAVVNASKSTREIWTTVLPPETKDVYT--AILGVTKASR 529
            |......|::|.|.|:...:..|:||...|:             |..|..::.  ..|.::....
  Fly   265 VNLGDSIILNCQADGTPTPEILWYKDANPVD-------------PSPTVGIFNDGTELRISTIRH 316

  Fly   530 IDEGVYSCKVTDWGVEQCRSLHIHIKSPPRLRVDPASVTLQRGDSLRVRC---LSPGNDDIKRYA 591
            .|.|.|:|...:...:...:..:.|.....:.|.|.:.|...|:.:...|   ..|||..::
  Fly   317 EDIGEYTCIARNGEGQVSHTARVIIAGGAVIMVPPTNQTKLEGEKVIFSCEAKAMPGNVTVR--- 378

  Fly   592 QLGYSWTRNGVLFQSDAATAMWEDLYPDGSILKINNIQ--KSAEYACLVSNSV-RPVSRSVYINV 653
                 |.|.|...:..||......:..|||:: ||.|:  .|.:|.|.|:|.: .|.|.|.|::
  Fly   379 -----WYREGSPVREVAALETRVTIRKDGSLI-INPIKPDDSGQYLCEVTNGIGDPQSASAYLS- 436

  Fly   654 IERNAVHVCPAESTYGVHWPTSAPGSPIITDCPRGFEGHLKRICEQRDTGN---STW-----LLP 710
                            |.:|.....:|.:...|....|.::  |..:.:..   .||     ||.
  Fly   437 ----------------VEYPAKVTFTPTVQYLPFRLAGVVQ--CYIKSSPQLQYVTWTKDKRLLE 483

  Fly   711 DFSGCVRDELLLIYNRFLALSAGFQQTNSSNILK-ACFEFTLQRRHSFLPGEASFLIDML----- 769
            .:.  ::|.:::.....|     |.:.|..:..: ||..:..|.     ...||.::|:|
  Fly   484 PYQ--MKDIVVMANGSLL-----FTRVNEEHQGQYACTPYNAQG-----TAGASGVMDVLVRKPP 536

  Fly   770 ---HELDTYLQLKGTQLEREMAAEIILRILDKVMQNAQSLNSQ--------QQIKKLQQLTQSAA 823
               .|.:|..|.|               :.|.|..:..:|.::        .|.::.:|||:|..
  Fly   537 AFTVEPETLYQRK---------------VGDSVEMHCDALEAEGTERPTIKWQRQEGEQLTESQR 586

  Fly   824 --------------LNRE---------------TIAASQL----------------ATSTSGSSQ 843
                          |.||               .:|.:||                ||.:|.:.|
  Fly   587 NRIKISGGNITIENLRREDFGYYQCVVSNEVATLMAVTQLVIEGTQPHAPYNITGKATESSITLQ 651

  Fly   844 PLPGDSSTRGDDGS-----------GSGVTAGE-MSAAPAGSLQATRAGGAGG------------ 884
            .|||.|.     ||           .:||...: :|..|:||.|.|..|.|.|
  Fly   652 WLPGYSG-----GSEYKQDYTIWFREAGVNDWQTISVTPSGSTQVTINGLASGTTYEFQVVGRNV 711

  Fly   885 -GPGGASSILTVD--EDTLSLDRLNSLRIYMTSVK--TLP----FNLRIYGEDLFSDQLYMDIGL 940
             |.|..|.::||.  ||..:..|         :||  |.|    |.|.....||.:   |.||
  Fly   712 LGDGMMSKVMTVRTLEDAPAAPR---------NVKAATQPPDSFFQLMPDEADLLA---YFDI-- 762

  Fly   941 SSRLLHIMANSTIFASVISYKNLKSFLPKTYYTRGSDPRD-SDYVLASRIIQTWLFQSNRSNDNF 1004
               ..|..:..|:   |.|...|:...||.     ..||: |...:::..:.||  ||
  Fly   763 ---YFHTDSRGTL---VYSPPKLRVKGPKP-----GPPRNVSVTEVSNGFLITW--QS------- 807

  Fly  1005 REPLDLPFEAGHVEIIFQHESVPKKGDWVAVCGHDYKASFDSTWRS----------DLCITKHLM 1059
                  |.|..|:                 |..:..|...|:.|::          ...:.|:|:
  Fly   808 ------PLERAHI-----------------VKFYTIKYRTDAQWKTLNRGQIRPEETQYLVKNLV 849

  Fly  1060 ANITRCICPLSGTYVVMLTKRQPNATPHNAPRRPIFVIASCACCLLQCGSALLILVPIWCNRKCA 1124
            ...|        .|..:|...:.:....:..:.|                     ||.....| |
  Fly   850 GGRT--------YYFRVLANSEKSYESSDEVKFP---------------------VPARVKHK-A 884

  Fly  1125 VTFLKMQFCVSTSSVMLIYLLGFMKMLPVSWHGIISSSLASLLLLGISTLIAIALAIHTELMPKK 1189
            :|                             .|::...|..::.: |.::.|:.:.
  Fly   885 IT-----------------------------AGVVGGILFFIVAI-ILSVCAVKIC--------- 910

  Fly  1190 YLQIGSKPATPTKRRLRREQERE-----------RERERDRDRERDRELDSLSNITQIRAQSPLG 1243
                        .:|.||:||:|           |....:.....:|...|:|:     .|.||
  Fly   911 ------------NKRKRRKQEKEFNMVACRITDARNIAANNHHLHNRSTGSISS-----GQVPL- 957

  Fly  1244 ATTASTTITTTTSSSNPGQRRPPPSSTAGMRGAIGISWLLPLLFAVAAPLICSIIGQWPRHWWLE 1308
                          ....|.|              ||.|..:|.|:.             ||
  Fly   958 --------------KKYKQTR--------------ISSLTAILIAIL-------------HW--- 978

  Fly  1309 VLWTGS---------ASPEAGAGKDEAGDSDSGAFYSAHSL------LNGDNLLLESEAVMGNGT 1358
             :|...         :||..     |.||.|.|......|:      |:| ..:|:.|.|...|.
  Fly   979 -IWPPDRCTNCHSIYSSPNL-----EDGDEDDGGGGRRRSVSRIQRSLDG-RFVLDVEGVSKLGY 1036

  Fly  1359 SSPPTETSSASSSSSSTGRAVDDDV-ATSTSSITSIGSASNSGF---------SASWSGITSFST 1413
            |....|:.:..        .||..: ....|:::...|:.:.||         .|||......|:
  Fly  1037 SQQTLESGNVD--------VVDGGLFERRNSNVSQKSSSDDGGFLSRRNFITARASWRRPLVASS 1093

  Fly  1414 STSTTSSTSTSVAALAAPLTSGPGDSSATPSPSLSF 1449
            |..:..|.:.|.......|.......||.|..|.|:
  Fly  1094 SQLSLQSAADSARGFLQGLLKIGAKQSAVPPNSQSY 1129

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG44153	NP_001097136.2	EGF_CA	<264..294	CDD:238011
		IG_like	467..554	CDD:214653	16/88 (18%)
		Ig	474..551	CDD:143165	15/78 (19%)
		IG_like	564..653	CDD:214653	27/94 (29%)
		Ig	572..642	CDD:299845	21/74 (28%)
		HRM	661..718	CDD:280888	10/64 (16%)
tutl	NP_001303307.1	V-set	137..250	CDD:284989
		IG_like	137..229	CDD:214653
		I-set	253..341	CDD:254352	16/88 (18%)
		IGc2	268..331	CDD:197706	15/75 (20%)
		I-set	346..437	CDD:254352	28/116 (24%)
		Ig	349..437	CDD:299845	28/113 (25%)
		Ig	459..530	CDD:299845	14/84 (17%)
		IG_like	549..628	CDD:214653	15/93 (16%)
		IGc2	551..617	CDD:197706	11/65 (17%)
		FN3	633..725	CDD:238020	26/96 (27%)
		FN3	786..874	CDD:238020	19/132 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10075
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100